How Stomach Cells Adapt to Heal Gastric Ulcers
Official title: Sox4 Dependent Parietal Cell Plasticity in Gastric Ulcer
Funded at Yale University · NIH-11184216 · Data updated 2026-11-12
This project explores how specific stomach cells change and adapt to help repair gastric ulcers, which are sores in the stomach lining.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 6, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $125,625 |
| NIH project number | 5R03DK137013-02 |
| Project ID | NIH-11184216 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients who have experienced gastric ulcers or related stomach conditions like atrophic gastritis or Ménétrier’s disease might find this research relevant to their condition.
✕Less likely to help
Patients without gastric ulcers or related stomach conditions would not directly benefit from this specific foundational research.
What this research studies
Gastric ulcers are a common problem, often caused by medications or infections, and can lead to serious health issues. While we understand many aspects of how ulcers heal, we still need to learn more about which specific cells are responsible for rebuilding the damaged stomach lining. This work focuses on special cells in the stomach called parietal cells, which normally produce acid. We aim to discover if these parietal cells can transform into other cell types to help repair the damage caused by ulcers and related conditions.
Why it matters
Potential benefit: If successful, this research could uncover new biological pathways that might be targeted to help the stomach heal itself more effectively after an ulcer.
How similar studies have gone: Preliminary work by this research team suggests that parietal cells can indeed change into other cell types, providing a strong foundation for this current investigation.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Huh, Won Jae — Yale University
- Study coordinator: Huh, Won Jae
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.