Investigating how mitochondrial function affects ulcer healing in inflammatory bowel disease.
Official title: The Role of Crypt Fissioning in IBD Ulcer Healing
Funded at University of Kentucky · NIH-10781979 · Data updated 2026-11-12
This study is looking at how the energy factories in your cells, called mitochondria, might affect the healing of ulcers in people with inflammatory bowel disease (IBD), and it hopes to find better ways to help you heal.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project start | February 24, 2021 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $633,715 |
| NIH project number | 5R01DK095662-13 |
| Project ID | NIH-10781979 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease, particularly those experiencing persistent mucosal ulceration.
✕Less likely to help
Patients with non-inflammatory bowel conditions or those who have already achieved remission may not benefit from this research.
What this research studies
This research focuses on understanding the role of mitochondrial respiration in the healing of ulcers associated with inflammatory bowel disease (IBD). It aims to explore how chronic inflammation may hinder the ability of intestinal epithelial cells to heal by affecting their mitochondrial function. The study will involve both animal models and potentially human samples to assess the relationship between mitochondrial activity and mucosal healing. By identifying the mechanisms behind ulcer healing, the research seeks to improve treatment strategies for patients with IBD.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that enhance ulcer healing in patients with inflammatory bowel disease.
How similar studies have gone: Previous studies have shown promising results in understanding the role of mitochondrial function in ulcer healing, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Kentucky
Lexington, United States Active
Researchers
- Principal investigator: Barrett, Terrence a. — University of Kentucky
- Study coordinator: Barrett, Terrence a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.