Investigating how certain stomach cells change in response to gastric ulcers
Official title: Sox4 Dependent Parietal Cell Plasticity in Gastric Ulcer
Funded at Yale University · NIH-10987605 · Data updated 2026-11-12
This study is looking at how certain stomach cells change during the healing of gastric ulcers, which can happen more often because of things like pain relievers and infections, and it hopes to find new ways to help people heal better from these ulcers.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 6, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $125,625 |
| NIH project number | 1R03DK137013-01A1 |
| Project ID | NIH-10987605 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from gastric ulcers or related gastrointestinal conditions.
✕Less likely to help
Patients with non-gastric ulcer related gastrointestinal issues may not receive direct benefits from this research.
What this research studies
This research focuses on understanding the behavior of parietal cells in the stomach during the healing process of gastric ulcers, which are becoming more common due to factors like NSAID use and Helicobacter pylori infections. The study aims to explore how these cells, which are crucial for acid secretion, may change into different cell types instead of simply dying off. By using mouse models, researchers will examine the molecular mechanisms behind this transformation and its implications for gastric ulcer repair. Patients may benefit from insights that could lead to improved treatments for gastric ulcers and related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating gastric ulcers and preventing complications.
How similar studies have gone: Previous research has shown promising results in understanding cell behavior in gastric conditions, indicating potential for success in this area.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Huh, Won Jae — Yale University
- Study coordinator: Huh, Won Jae
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.