Using steroids and cross-linking to treat corneal ulcers
Official title: Steroids and Cross-linking for Ulcer Treatment (SCUT II)
Funded at University of California, San Francisco · NIH-10666415 · Data updated 2026-11-12
This study is looking at whether using steroids along with a special eye treatment can help people with serious vision loss from bacterial corneal ulcers heal better and see more clearly.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | August 1, 2019 |
| Project end | January 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $745,915 |
| NIH project number | 5UG1EY028518-05 |
| Project ID | NIH-10666415 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals presenting with smear-positive bacterial corneal ulcers and moderate to severe vision loss.
✕Less likely to help
Patients with non-bacterial corneal ulcers or those with mild vision loss may not benefit from this research.
What this research studies
This research investigates how combining steroids with corneal cross-linking can improve treatment outcomes for patients suffering from bacterial corneal ulcers. The study will involve patients with moderate to severe vision loss due to these ulcers, who will be randomly assigned to receive one of three treatment options. By focusing on reducing inflammation and promoting healing, the research aims to enhance visual acuity and overall recovery. Participants will be monitored closely to assess the effectiveness of the treatments.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options that enhance vision recovery for patients with bacterial corneal ulcers.
How similar studies have gone: Previous studies have shown mixed results regarding the use of steroids in treating corneal ulcers, indicating that this approach may provide new insights into effective treatments.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Lietman, Thomas M — University of California, San Francisco
- Study coordinator: Lietman, Thomas M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.