Improving outcomes for corneal ulcers by detecting pathogens and antibiotic resistance
Official title: Improving Corneal Ulcer Outcomes with Unbiased Pathogen and Antimicrobial Resistance Detection
Funded at University of California, San Francisco · NIH-11088773 · Data updated 2026-11-12
This study is looking at infections in the eye that can cause serious vision problems, and it's for anyone who wants to help improve how these infections are diagnosed and treated by tracking the germs that cause them and how they respond to antibiotics in different places and times of the year.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | May 1, 2022 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $407,641 |
| NIH project number | 5R01EY032861-04 |
| Project ID | NIH-11088773 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals of all ages suffering from infectious corneal ulcers.
✕Less likely to help
Patients with corneal ulcers caused by non-infectious factors may not benefit from this research.
What this research studies
This research focuses on understanding infectious corneal ulcers, which can lead to significant vision loss. It aims to improve the diagnosis and treatment of these infections by conducting worldwide surveillance of the pathogens responsible for corneal ulcers and their resistance to antibiotics. The study will analyze how different geographic locations and seasonal changes affect the types of pathogens and their resistance profiles. Additionally, it will explore the local immune responses to these infections to better predict outcomes and tailor treatments.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for corneal ulcers, reducing the risk of vision loss for patients.
How similar studies have gone: Previous research has shown promise in improving treatment outcomes for infectious keratitis through better pathogen identification and understanding of antibiotic resistance.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Doan, Thuy a — University of California, San Francisco
- Study coordinator: Doan, Thuy a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.