Understanding heart issues in patients with repaired tetralogy of Fallot
Pathophysiologic Mechanism for Arrhythmias and Impaired Aerobic Capacity in Tetralogy of Fallot
This study is looking at why some people who have had surgery for tetralogy of Fallot experience heart rhythm problems and trouble with exercise, and it hopes to find out if fixing a specific heart valve early on can help them feel better and live longer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10908524 on NIH RePORTER |
What this research studies
This research investigates the causes of arrhythmias and reduced aerobic capacity in individuals who have undergone repair for tetralogy of Fallot, a congenital heart defect. It focuses on how elevated right atrial pressure may lead to these symptoms and the subsequent risk of right heart failure. By using echocardiographic assessments, the study aims to identify the mechanisms behind these complications and explore whether early intervention, such as pulmonary valve replacement, can improve patient outcomes. The goal is to enhance understanding of these conditions to ultimately prevent premature cardiovascular deaths in this patient population.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals under 21 years old who have undergone repair for tetralogy of Fallot and are experiencing symptoms like arrhythmias or reduced aerobic capacity.
Not a fit: Patients who have not had surgical repair for tetralogy of Fallot or those without symptoms related to arrhythmias or aerobic capacity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that prevent serious heart complications in patients with tetralogy of Fallot.
How similar studies have performed: Previous research has indicated that understanding the mechanisms of heart failure in congenital heart disease can lead to significant advancements in treatment, suggesting that this approach may yield valuable insights.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Egbe, Alexander — Mayo Clinic Rochester
- Study coordinator: Egbe, Alexander
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.