Understanding heart issues in patients with repaired tetralogy of Fallot
Official title: Pathophysiologic Mechanism for Arrhythmias and Impaired Aerobic Capacity in Tetralogy of Fallot
Funded at Mayo Clinic Rochester · NIH-10908524 · Data updated 2026-11-12
This study is looking at why some people who have had surgery for tetralogy of Fallot experience heart rhythm problems and trouble with exercise, and it hopes to find out if fixing a specific heart valve early on can help them feel better and live longer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | August 1, 2021 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $562,953 |
| NIH project number | 5R01HL158517-04 |
| Project ID | NIH-10908524 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals under 21 years old who have undergone repair for tetralogy of Fallot and are experiencing symptoms like arrhythmias or reduced aerobic capacity.
✕Less likely to help
Patients who have not had surgical repair for tetralogy of Fallot or those without symptoms related to arrhythmias or aerobic capacity may not benefit from this research.
What this research studies
This research investigates the causes of arrhythmias and reduced aerobic capacity in individuals who have undergone repair for tetralogy of Fallot, a congenital heart defect. It focuses on how elevated right atrial pressure may lead to these symptoms and the subsequent risk of right heart failure. By using echocardiographic assessments, the study aims to identify the mechanisms behind these complications and explore whether early intervention, such as pulmonary valve replacement, can improve patient outcomes. The goal is to enhance understanding of these conditions to ultimately prevent premature cardiovascular deaths in this patient population.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that prevent serious heart complications in patients with tetralogy of Fallot.
How similar studies have gone: Previous research has indicated that understanding the mechanisms of heart failure in congenital heart disease can lead to significant advancements in treatment, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Egbe, Alexander — Mayo Clinic Rochester
- Study coordinator: Egbe, Alexander
Related research
Other NIH-funded projects on the same topics.
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Why repaired Tetralogy of Fallot can cause heart rhythm problems and low exercise capacity
This project looks at whether rising pressure in the right atrium leads to arrhythmias and worse exercise ability in adults who had Tetralogy of Fallot repaired.
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Using beta-blockers to help heart cells grow in children with Tetralogy of Fallot
This study is looking at how a type of medicine called beta-blockers might help heart muscle cells grow in children with Tetralogy of Fallot, a heart condition they were born with, to better understand how to improve their heart function after surgery.
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Using AI to predict heart function in patients with repaired tetralogy of Fallot
This study is looking to make it easier for people who have had surgery for tetralogy of Fallot to understand their heart health by using advanced technology to analyze heart tests, so they can avoid extra MRIs and get better care.
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New MRI techniques to predict heart issues in patients with tetralogy of Fallot
This study is looking to help people who have had surgery for tetralogy of Fallot by using special heart scans to better predict serious heart problems, so doctors can know when to step in and provide the right care.
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Evaluating heart function in adults with tetralogy of Fallot
This study is looking at how well the hearts of adults who had surgery for tetralogy of Fallot are working, using a new type of CT scan to find any problems that regular tests might miss, so we can help improve their care and health in the long run.
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Understanding heart changes in children with Tetralogy of Fallot
This study looks at how the hearts of children with Tetralogy of Fallot change over time, especially the right ventricle, to help doctors find out which kids might need extra care after their surgery.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.