Understanding heart changes in children with Tetralogy of Fallot
Official title: Right Ventricular Remodeling in Tetralogy of Fallot
Funded at University of Pennsylvania · NIH-10897232 · Data updated 2026-11-12
This study looks at how the hearts of children with Tetralogy of Fallot change over time, especially the right ventricle, to help doctors find out which kids might need extra care after their surgery.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 1, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $56,974 |
| NIH project number | 5F30HL162429-03 |
| Project ID | NIH-10897232 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who have been diagnosed with Tetralogy of Fallot and have undergone surgical repair.
✕Less likely to help
Patients who do not have Tetralogy of Fallot or are older than 11 years may not benefit from this research.
What this research studies
This research investigates how the heart changes in children with Tetralogy of Fallot (ToF), a common congenital heart defect. It focuses on the right ventricle, which can become enlarged and dysfunctional even after surgical repair. By using advanced imaging techniques like cardiovascular magnetic resonance (CMR), the study aims to identify which patients are at risk for complications related to these heart changes. The goal is to improve monitoring and treatment strategies for affected children.
Why it matters
Potential benefit: If successful, this research could lead to better management and outcomes for children with Tetralogy of Fallot by identifying those at risk for serious heart complications.
How similar studies have gone: Previous research has shown success in using advanced imaging techniques to assess heart conditions, indicating that this approach may yield valuable insights.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Thompson, Elizabeth Walker — University of Pennsylvania
- Study coordinator: Thompson, Elizabeth Walker
Related research
Other NIH-funded projects on the same topics.
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Why repaired Tetralogy of Fallot can cause heart rhythm problems and low exercise capacity
This project looks at whether rising pressure in the right atrium leads to arrhythmias and worse exercise ability in adults who had Tetralogy of Fallot repaired.
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Using beta-blockers to help heart cells grow in children with Tetralogy of Fallot
This study is looking at how a type of medicine called beta-blockers might help heart muscle cells grow in children with Tetralogy of Fallot, a heart condition they were born with, to better understand how to improve their heart function after surgery.
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Using AI to predict heart function in patients with repaired tetralogy of Fallot
This study is looking to make it easier for people who have had surgery for tetralogy of Fallot to understand their heart health by using advanced technology to analyze heart tests, so they can avoid extra MRIs and get better care.
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New MRI techniques to predict heart issues in patients with tetralogy of Fallot
This study is looking to help people who have had surgery for tetralogy of Fallot by using special heart scans to better predict serious heart problems, so doctors can know when to step in and provide the right care.
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Evaluating heart function in adults with tetralogy of Fallot
This study is looking at how well the hearts of adults who had surgery for tetralogy of Fallot are working, using a new type of CT scan to find any problems that regular tests might miss, so we can help improve their care and health in the long run.
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Understanding heart issues in patients with repaired tetralogy of Fallot
This study is looking at why some people who have had surgery for tetralogy of Fallot experience heart rhythm problems and trouble with exercise, and it hopes to find out if fixing a specific heart valve early on can help them feel better and live longer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.