New MRI techniques to predict heart issues in patients with tetralogy of Fallot
Official title: Novel Cardiac MRI-Based Predictors for Tetralogy of Fallot: Deformation, Kinematic, and Geometric Analyses
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-11011367 · Data updated 2026-11-12
This study is looking to help people who have had surgery for tetralogy of Fallot by using special heart scans to better predict serious heart problems, so doctors can know when to step in and provide the right care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | February 15, 2021 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $159,163 |
| NIH project number | 5K23HL150279-05 |
| Project ID | NIH-11011367 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with repaired tetralogy of Fallot, particularly those at risk for serious heart complications.
✕Less likely to help
Patients without a history of tetralogy of Fallot or those who have not undergone surgical repair for this condition may not benefit from this research.
What this research studies
This research focuses on improving the prediction of serious heart complications in patients who have undergone repair for tetralogy of Fallot, a congenital heart defect. By utilizing advanced cardiac MRI techniques, the study aims to develop new metrics that can better assess heart function and predict outcomes such as death and dangerous heart rhythms. The approach involves analyzing heart deformation, movement, and geometry from standard MRI scans, which could lead to more accurate timing for necessary interventions like pulmonary valve replacement. Patients will be monitored to evaluate how these new predictors correlate with clinical outcomes.
Why it matters
Potential benefit: If successful, this research could lead to more accurate predictions of heart complications, allowing for timely interventions that could save lives.
How similar studies have gone: Previous research has shown promise in using advanced imaging techniques for cardiac assessments, suggesting that this approach could yield significant advancements in patient care.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Tandon, Animesh — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Tandon, Animesh
Related research
Other NIH-funded projects on the same topics.
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Why repaired Tetralogy of Fallot can cause heart rhythm problems and low exercise capacity
This project looks at whether rising pressure in the right atrium leads to arrhythmias and worse exercise ability in adults who had Tetralogy of Fallot repaired.
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Using beta-blockers to help heart cells grow in children with Tetralogy of Fallot
This study is looking at how a type of medicine called beta-blockers might help heart muscle cells grow in children with Tetralogy of Fallot, a heart condition they were born with, to better understand how to improve their heart function after surgery.
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Using AI to predict heart function in patients with repaired tetralogy of Fallot
This study is looking to make it easier for people who have had surgery for tetralogy of Fallot to understand their heart health by using advanced technology to analyze heart tests, so they can avoid extra MRIs and get better care.
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Evaluating heart function in adults with tetralogy of Fallot
This study is looking at how well the hearts of adults who had surgery for tetralogy of Fallot are working, using a new type of CT scan to find any problems that regular tests might miss, so we can help improve their care and health in the long run.
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Understanding heart issues in patients with repaired tetralogy of Fallot
This study is looking at why some people who have had surgery for tetralogy of Fallot experience heart rhythm problems and trouble with exercise, and it hopes to find out if fixing a specific heart valve early on can help them feel better and live longer.
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Understanding heart changes in children with Tetralogy of Fallot
This study looks at how the hearts of children with Tetralogy of Fallot change over time, especially the right ventricle, to help doctors find out which kids might need extra care after their surgery.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.