Using beta-blockers to help heart cells grow in children with Tetralogy of Fallot
Mechanistic clinical trial of Beta-blocker administration for reactivating cardiomyocyte division in Tetralogy of Fallot
This study is looking at how a type of medicine called beta-blockers might help heart muscle cells grow in children with Tetralogy of Fallot, a heart condition they were born with, to better understand how to improve their heart function after surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11080369 on NIH RePORTER |
What this research studies
This research investigates how beta-blockers can stimulate the division of heart muscle cells in children diagnosed with Tetralogy of Fallot, a common congenital heart defect. The study focuses on understanding the mechanisms behind heart failure in these patients, particularly how their heart's right ventricle remodels after surgical repair. By using a special imaging technique that tracks the incorporation of a labeled compound into DNA, researchers aim to visualize and measure cardiomyocyte division. This innovative approach could lead to new treatments that improve heart function in affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who have been diagnosed with Tetralogy of Fallot.
Not a fit: Patients with other forms of congenital heart disease or those outside the specified age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance heart muscle regeneration and improve outcomes for children with congenital heart defects.
How similar studies have performed: While the use of beta-blockers in heart disease is established, the specific approach of stimulating cardiomyocyte division in this context is novel and has not been extensively tested.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Kuhn, Bernhard — Weill Medical Coll of Cornell Univ
- Study coordinator: Kuhn, Bernhard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.