Investigating immune responses in kidney transplant rejection
Official title: Single Cell Analysis of Alloreactive CD8+ T Cells in Kidney Transplant Rejection
Funded at University of Cincinnati · NIH-11248001 · Data updated 2026-11-12
This study is looking at how certain immune cells in your body might affect the success of kidney transplants, especially if you've had previous infections, to help find better treatments that could reduce the need for long-term medication after surgery.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | November 22, 2022 |
| Project end | July 21, 2026 |
| Funding year | 2025 |
| Award (this year) | $53,974 |
| NIH project number | 5F30AI167482-04 |
| Project ID | NIH-11248001 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have received a kidney transplant and are experiencing or at risk of transplant rejection.
✕Less likely to help
Patients who have not undergone kidney transplantation or those with stable graft function are unlikely to benefit from this research.
What this research studies
This research focuses on understanding how specific immune cells, known as CD8+ T cells, contribute to the rejection of kidney transplants. By analyzing these cells from patients experiencing rejection, the study aims to uncover how prior infections may influence the immune response against transplanted kidneys. The approach involves examining tissue samples from both human and mouse models to identify patterns in T cell behavior and gene expression. This could lead to more effective treatments that minimize the need for lifelong immunosuppression.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing kidney transplant rejection, enhancing patient outcomes and graft survival.
How similar studies have gone: Previous research has shown promise in understanding T cell responses in transplant rejection, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Shi, Tiffany — University of Cincinnati
- Study coordinator: Shi, Tiffany
Related research
Other NIH-funded projects on the same topics.
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Immunological mechanisms behind treatment-resistant kidney transplant rejection
This grant explores why certain kidney transplant rejections don’t respond to standard treatments and what immune cells in the graft are driving that resistance.
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Investigating T cells involved in kidney transplant rejection
This study is looking at how certain immune cells called CD8+ T cells play a role in kidney transplant rejection, especially in patients who have had past infections, to help find better ways to prevent rejection and improve transplant success.
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Using a new type of immune cell therapy to prevent and treat kidney transplant rejection
This study is exploring a new type of immune cell that could help prevent kidney transplant rejection by stopping harmful antibodies, and it's designed for people who have received a kidney transplant and want to improve their chances of success.
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Understanding how BK virus links infection to kidney transplant rejection
This project looks at how BK polyomavirus reactivation affects kidney transplant patients and aims to use pre-transplant T cell information to tailor immunosuppression and monitoring.
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Microbial clues to diagnose and predict infections in kidney transplant patients
A patient-focused project will look for microbial biomarkers in stool, blood, and urine to help doctors predict and diagnose infections in people who have had a kidney transplant.
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Complement-Bound Exosomes and Kidney Transplant Immunity
This project studies how kidney transplant injury and rejection happen after surgery and whether blocking certain immune pathways during organ preservation could improve transplant outcomes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.