Investigating immune responses in kidney transplant rejection
Single Cell Analysis of Alloreactive CD8+ T Cells in Kidney Transplant Rejection
This study is looking at how certain immune cells in your body might affect the success of kidney transplants, especially if you've had previous infections, to help find better treatments that could reduce the need for long-term medication after surgery.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11248001 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific immune cells, known as CD8+ T cells, contribute to the rejection of kidney transplants. By analyzing these cells from patients experiencing rejection, the study aims to uncover how prior infections may influence the immune response against transplanted kidneys. The approach involves examining tissue samples from both human and mouse models to identify patterns in T cell behavior and gene expression. This could lead to more effective treatments that minimize the need for lifelong immunosuppression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have received a kidney transplant and are experiencing or at risk of transplant rejection.
Not a fit: Patients who have not undergone kidney transplantation or those with stable graft function are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing kidney transplant rejection, enhancing patient outcomes and graft survival.
How similar studies have performed: Previous research has shown promise in understanding T cell responses in transplant rejection, suggesting that this approach could yield valuable insights.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Shi, Tiffany — University of Cincinnati
- Study coordinator: Shi, Tiffany
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.