Condition

Heart Transplant clinical trials and research

• 11Clinical trials
• 9NIH research projects
• 4Countries

Newest Heart Transplant clinical trials

All recruiting trials (11)

• Non-invasive test to predict early heart rejection in pediatric transplant patients

  This study tests non-invasive heart tests like cardiac MRI and blood markers to see if they can detect rejection in kids after heart transplant, potentially reducing the need for invasive biopsies.

  Recruiting at 22 sites Vanderbilt University Medical Center · Little Rock, Arkansas and 21 other locations · NCT07770659

• Non-intubated anesthesia for adult heart transplantation

  This trial tests whether keeping patients breathing on their own with a supraglottic airway during heart transplantation leads to fewer complications and faster recovery compared with standard intubated anesthesia.

  Recruiting The First Affiliated Hospital of Guangzhou Medical University · Guangzhou, Guangdong · NCT07758894

• Apixaban vs Warfarin in HeartMate 3 LVAD Patients

  This study tests whether apixaban can replace warfarin to prevent clots and bleeding problems in adults with an implanted HeartMate 3 LVAD for at least 3 months.

  Recruiting Phase 3 Columbia University · New York, New York · NCT07471139

• Improving donor heart preservation with the OCS Heart System

  This study will test whether the OCS Heart System with a new preservation solution and a functional enhancer helps donor hearts—including DCD and higher‑risk DBD hearts—stay healthier and improve transplant outcomes compared with standard cold storage.

  Recruiting at 7 sites TransMedics · San Francisco, California and 7 other locations · NCT07145515

• XVIVO Heart Box non-ischemic preservation for transporting donor hearts.

  This program tests whether the XVIVO non-ischemic heart preservation system can safely preserve extended-criteria donor hearts for adults waiting for a heart transplant.

  Recruiting at 14 sites XVIVO Perfusion · La Jolla, California and 13 other locations · NCT06895070

• Empagliflozin to protect kidney and heart health after heart transplant

  This trial will test whether empagliflozin can protect kidney and heart health and improve metabolic and functional outcomes in Veterans who have had a heart transplant.

  Recruiting Phase 4 VA Office of Research and Development · Palo Alto, California and 5 other locations · NCT06625073

• Using belatacept for heart transplant patients

  This study is testing if a new medication called belatacept can safely help heart transplant patients avoid rejection and complications compared to the usual treatment.

  Recruiting at 6 sites Phase 2 National Institute of Allergy and Infectious Diseases (NIAID) · Los Angeles, California and 7 other locations · NCT06478017

• Effects of resistance training for patients waiting for heart transplants

  This study tests if a resistance training program can help heart failure patients waiting for a transplant feel better and improve their overall health.

  Recruiting University of Sao Paulo General Hospital · São Paulo, São Paulo · NCT06426173

• Registry for heart transplant outcomes using OCS Heart System

  This study tracks how well the OCS Heart System works for preserving donor hearts in heart transplant patients over five years to see if it helps them do better after surgery.

  Recruiting at 37 sites TransMedics · Phoenix, Arizona and 36 other locations · NCT05915299

• Exercise, lung, and heart fitness in young survivors of heart transplant, childhood leukemia, and premature lung disease

  This project tests non-invasive exercise and breathing tests to see how well 8–25-year-olds who survived childhood leukemia, were born with chronic lung disease of prematurity, or had a heart transplant tolerate and perform during physical activity.

  Recruiting Masonic Cancer Center, University of Minnesota · Minneapolis, Minnesota · NCT05025774

• Investigating antiplatelet therapy to prevent complications in heart transplant patients

  This study tests if giving heart transplant patients early treatment with aspirin or clopidogrel can help prevent a common problem where their heart arteries narrow.

  Recruiting at 3 sites Phase 3 Ottawa Heart Institute Research Corporation · Vancouver, British Columbia and 2 other locations · NCT04770012

NIH-funded research (9)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Pediatric Heart Pump to Let Kids Go Home While Waiting for Transplant

  A new ultra-low-power pediatric heart pump is being developed so children awaiting a heart transplant can go home or live with the device.

  NIH research Corvion, INC. · Webster, United States · NIH-11407580

• Predicting acute rejection in children after heart transplant

  A study to improve how doctors predict if a child who has had a heart transplant will have acute rejection using noninvasive blood markers and advanced heart MRI analysis.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11364137

• Molecular mismatch as a marker of immune risk in heart transplant patients

  A study to see if specific biological differences between donor and recipient hearts can predict immune reactions and guide personalized immunosuppression in people who receive heart transplants.

  NIH research New York University School of Medicine · New York, United States · NIH-11361056

• Fair and efficient heart transplant allocation using AI-powered continuous distribution

  A NIH-funded project will develop fair and efficient computer-based methods to match donated hearts with patients needing transplants.

  NIH research University of Chicago · Chicago, United States · NIH-11298724

• Better ways to find heart transplant rejection in children

  This research aims to find less invasive and more accurate ways to detect when a child's body is rejecting a new heart.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11109734

• Investigating a medication to protect kidney function in heart transplant patients

  This study is looking at whether a medication called empagliflozin can help improve kidney health and overall well-being in heart transplant patients who are at risk for kidney and heart problems, and we're inviting Veterans to join us in this important research.

  NIH research VA Salt Lake City Healthcare System · Salt Lake City, United States · NIH-11048998

• Discovering biomarkers to improve heart transplant outcomes

  This study is looking at how new technologies can help find important signs in heart transplant patients to better predict and manage issues like rejection, so that doctors can provide more personalized care and improve recovery for those patients.

  NIH research New York University School of Medicine · New York, United States · NIH-10997887

• Improving detection of acute rejection in children who have heart transplants

  This study is looking for safer ways to check for heart transplant rejection in kids by using blood tests and special imaging instead of needing risky biopsies, helping to keep young patients healthier and more comfortable.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-10875416

• Using a mobile app to help young heart transplant patients take their medications

  This study is looking at whether a mobile app that helps teens who have had a heart transplant remember to take their medications works better than regular check-ins with doctors, to see which way helps them stay healthy and feel better overall.

  NIH research Emocha Mobile Health, INC. · Owings Mills, United States · NIH-10818337

Related topics

Quick answers

How many Heart Transplant clinical trials are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in United States (8 trials), China (1 trial), Canada (1 trial), Brazil (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 2, Phase 4: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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