Analyzing liver grafts to predict transplant outcomes
Tissue Analysis (Histological, Ultrastructural and Molecular) of Liver Grafts as a Predictor of Transplant Outcome.
This study is testing if certain markers in liver grafts can help predict how well the transplant will work for patients receiving the liver.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | IRCCS Azienda Ospedaliero-Universitaria di Bologna Academic / other |
| Locations | 1 site (Bologna) |
| Trial ID | NCT06717542 on ClinicalTrials.gov |
What this trial studies
This study aims to identify specific endothelial signatures in liver grafts after undergoing a process called HOPE, which is used prior to transplantation. It involves two patient cohorts: liver donors, who will have a biopsy taken for organ quality assessment, and liver recipients, who will undergo a study-specific biopsy after the transplant. The biopsies will be analyzed using histochemical and immunohistochemical techniques, as well as RT-PCR, to uncover molecular changes that could inform personalized perfusion treatments in the future.
Who should consider this trial
Good fit: Ideal candidates include liver donors and recipients aged 18 years or older who can provide sufficient tissue for analysis.
Not a fit: Patients who do not undergo HOPE treatment on their liver grafts may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved outcomes for liver transplant patients by enabling personalized treatment strategies.
How similar studies have performed: While the approach of analyzing endothelial signatures in liver grafts is innovative, similar studies have shown promise in understanding transplant outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * For Donors: Availability of enough tissue for histological, immunohistochemical and RT-PCR analysis. * HOPE performed on the liver graft prior to transplantation. * For Recipients: * Availability of enough tissue for histological, immunohistochemical and RT-PCR analysis. * Age greater than/equal to 18 years. Exclusion Criteria: * None
Where this trial is running
Bologna
- IRCCS Azienda Ospedaliero-Universitaria di Bologna — Bologna, Italy (Recruiting)
Study contacts
- Principal investigator: Francesco Vasuri, MD — IRCCS Azienda Ospedaliero-Universitaria di Bologna
- Study coordinator: Francecso Vasuri, MD
- Email: francesco.vasuri2@unibo.it
- Phone: 0512143761
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.