Condition

Primary Care clinical trials and research

• 13Clinical trials
• 432NIH research projects
• 7Countries

Newest Primary Care clinical trials

All recruiting trials (13)

• Suicide prevention in primary care clinics in Nepal

  This project will try a package of tools and training to help primary care providers in Bagmati Province, Nepal, better find and manage patients at risk of suicide.

  Recruiting Yale University · Dolakhā · NCT07362056

• Explicit 15-minute arrival-time messages to help patients arrive on time

  This project will test whether showing an explicit arrival time (15 minutes before the scheduled appointment) in MyChart and automated texts helps primary care patients arrive on time for in-person visits.

  Recruiting University of California, Los Angeles · Los Angeles, California · NCT07314697

• Patient-centered clinical decision support for recommended screenings in primary care

  This project will test a patient-centered computer tool that helps adults aged 18–74 and their primary care doctors identify which preventive screenings are recommended and support shared decision-making.

  Recruiting at 12 sites Hospices Civils de Lyon · Belley and 19 other locations · NCT07270926

• Reducing unnecessary antibiotics for urinary tract infections by improving urine collection

  This study will test whether a bilingual (English and Spanish) animated video and pictorial flyer can help adults in safety‑net primary care give cleaner urine samples to reduce contaminated cultures and unnecessary antibiotic prescriptions.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT07246837

• Making AI triage more accurate for patients contacting their GP

  This project will test whether updated AI in the Patchs online consultation system can make triage decisions more accurate and fair for patients contacting GP practices in England.

  Recruiting University of Manchester · London · NCT07237919

• Project CARE: Hereditary cancer risk checks in primary care

  This project will test whether sending primary care patients a chatbot link can identify people at high hereditary cancer risk and connect them to genetic counseling and testing.

  Recruiting Rutgers, The State University of New Jersey · New Brunswick, New Jersey · NCT07130487

• Clinic-based program to prevent teen dating violence for adolescents and caregivers

  This pilot will try a clinic-delivered program that helps teens (ages 12–16) and their caregivers improve communication and reduce dating violence during routine pediatric well visits.

  Recruiting University of Pittsburgh · Monongahela, Pennsylvania · NCT07039253

• Blood biomarker plus questionnaire test to help diagnose bipolar disorder

  This trial will test whether a blood-based biomarker algorithm combined with the Mood Disorder Questionnaire (MDQ) can accurately identify adults with bipolar disorder who are currently experiencing a major depressive episode in primary care.

  Recruiting University Hospital, Montpellier · Montpellier · NCT07031817

• Using an AI tool to prioritize specialty referrals for primary care patients

  This project will test whether an AI tool can sort and prioritize specialty-care referrals so primary care patients with chronic conditions get more timely and appropriate specialist access.

  Recruiting Hospital de Clinicas de Porto Alegre · Porto Alegre, Rio Grande do Sul · NCT07019116

• Improving pain management for patients on long-term opioid therapy

  This study is testing a new team-based approach to help people on long-term opioid therapy manage their chronic pain better than the usual care they currently receive.

  Recruiting at 2 sites Uppsala County Council, Sweden · Gävle, Gävleborg County and 3 other locations · NCT06856733

• Creating a tailored intervention for caregivers of Alzheimer's patients

  This study is trying to create a personalized support program for caregivers of people with Alzheimer's to help them manage their unique challenges better.

  Recruiting at 2 sites University Hospital, Tours · Amboise and 2 other locations · NCT06852326

• Collaborative GP-Pharmacist Approach to Tapering Benzodiazepines in Older Adults

  This study tests whether a GP-pharmacist collaboration and pharmacist-led motivational interviewing can help people aged 65 and older reduce or stop benzodiazepines prescribed for anxiety or sleep.

  Recruiting Nantes University Hospital · Nantes · NCT05765656

• Helping families in poverty improve health and well-being

  This study tests whether having a Community Support Worker can help families with young children who are struggling financially to improve their income, reduce stress, and boost their children's health.

  Recruiting Queen's University · Kingston, Ontario · NCT05091957

NIH-funded research (newest 40 of 432)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• HEARTS hypertension and diabetes care in Guatemala

  This grant tests how well the HEARTS primary care model works in Guatemala to improve blood pressure and blood sugar control for patients.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11645315

• Primary Care HEART-NET: boosting access to research in the Deep South

  A collaboration across three universities will build primary care research networks in Alabama, Arkansas, and Mississippi to improve access to care and help prevent and manage chronic diseases.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11618658

• Primary Care Bridge: Building Research in Diverse Geographic Settings

  A national network hub in New Mexico will connect rural clinics and communities to faster, more usable primary care research so patients in underserved areas can benefit from new evidence.

  NIH research University of New Mexico Health Scis Ctr · Albuquerque, United States · NIH-11618652

• WREN: Expanding Research Capacity in Rural Primary Care Clinics

  A nationwide network in Wisconsin will strengthen rural primary care clinics to participate in real-world research and bring more clinical trials to communities.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11618649

• Primary care research network in Oklahoma to boost rural patient trials

  A nationwide NIH-supported effort to strengthen Oklahoma’s primary care research network so doctors can run big clinical trials and real‑world studies in rural communities.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-11618645

• PRaCTICe: A Rural and Frontier Clinical Trials Innovation Center

  A nationwide network is creating easier, community-led clinical trials in rural and frontier areas to bring more trials to patients where they live.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11612362

• Stepped Care, Peer-Delivered Help for ART Adherence and Substance Use in Primary Care

  A peer-delivered, stepped-care program in busy primary care clinics helps people living with HIV stay adherent to ART and address substance use, aiming to fit resources and improve outcomes.

  NIH research Univ of Maryland, College Park · College Park, United States · NIH-11609163

• Understanding and addressing early childhood exposure to violence in pediatric primary care

  A doctor-and-patient-focused project to help pediatric clinics identify and respond to violence exposure in young children to improve health and development.

  NIH research University of Washington · Seattle, United States · NIH-11597810

• Digital support to spread team-based schizophrenia care in primary care in India

  A project to help frontline health workers in India use digital tools to provide coordinated schizophrenia care in primary care, with plans to inform care in the United States as well.

  NIH research Harvard Medical School · Boston, United States · NIH-11580818

• Digital support for shared-care of schizophrenia in primary care in India

  A patient-friendly plan to bring evidence-based schizophrenia care to primary care in India using digital tools and trained frontline workers.

  NIH research Harvard Medical School · Boston, United States · NIH-11580817

• Digital support to scale Schizophrenia care in primary care in India

  A nationwide effort to help primary care teams in India deliver better, more accessible schizophrenia care using digital tools and trained frontline workers.

  NIH research Harvard Medical School · Boston, United States · NIH-11580816

• Single-session intervention and interpersonal therapy for teen depression in Mozambican clinics

  A pilot, real-world trial tests if a one-visit program plus coaching helps depressed teens in Mozambique access care and feel better.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11553169

• Collaborating Center for Arthritis Care Tools and a Coordinating Center for an Arthritis Management & Wellbeing Network

  A coordinated NIH program aims to improve how primary care providers refer people with arthritis to evidence-based, self-management programs and to boost participation, especially among groups facing disparities.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11503933

• Nurse-led care at local clinics versus doctor-led hospital care for rifampicin‑resistant TB

  This project compares nurse-led treatment for rifampicin-resistant tuberculosis offered at local primary care clinics to doctor-led care at district hospitals for people with RR-TB.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11494911

• Treating Alcohol Use Disorder in Primary Care with Semaglutide

  This grant tests whether the diabetes drug semaglutide can help adults reduce or stop drinking when used in primary care.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11491479

• NEMOURS Move to Improve Blood Pressure Diagnosis in Kids and Teens

  A program to help kids and young people with suspected high blood pressure get timely diagnosis by improving access to home-style blood pressure monitoring and sharing easy, local resources.

  NIH research Nemours Children's Hospital, Delaware · Wilmington, United States · NIH-11468416

• Helping primary care patients and clinicians use Alzheimer’s biomarkers

  A patient-friendly project to help primary care teams use blood biomarkers to better understand and diagnose Alzheimer’s disease in people with memory or thinking problems.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11463105

• A Universal Primary Care Program to Reduce Youth Overdose Risk

  A primary care–based program for teens and young adults to learn about fentanyl and other drugs, and to get practical steps to prevent overdoses.

  NIH research Boston Medical Center · Boston, United States · NIH-11454664

• Long-Term Effects of Hurricanes on Primary Care Availability

  This project looks at how major hurricanes affect whether primary care doctors are available and used, especially for older adults with chronic conditions.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11453229

• How eviction affects preventive and primary care

  This project looks at how losing housing affects people’s ability to get routine preventive and primary care.

  NIH research Drexel University · Philadelphia, United States · NIH-11450177

• GrowSmart: A kid-friendly AI tool to help primary care teams prevent obesity

  A pediatric primary care tool using artificial intelligence helps identify kids at risk for obesity and supports doctors and families in choosing healthy lifestyle steps.

  NIH research Nemours Children's Hospital, Delaware · Wilmington, United States · NIH-11449950

• Primary Care After Pregnancy: A New Way to Support Interconception Health

  Aimed at improving the health of women after childbirth by testing a new primary-care–based model to deliver interconception care.

  NIH research University of Chicago · Chicago, United States · NIH-11449012

• ASPIRE: Making self-measured blood pressure work for primary care patients

  A practical plan to help adults manage high blood pressure by using home blood pressure readings in regular clinic care.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11448754

• Early alcohol-use screening in primary care to catch liver disease earlier

  A primary-care based study tests whether using a short alcohol-screening questionnaire can help identify people at risk for alcohol-associated liver disease sooner.

  NIH research Kaiser Foundation Research Institute · Oakland, UNITED STATES · NIH-11448516

• Recovery Management Checkups for Primary Care in FQHCs

  A plan to bring a proven support program for people with alcohol and other substance use disorders into real-world primary care clinics serving underserved communities.

  NIH research Chestnut Health Systems, INC. · Bloomington, United States · NIH-11448363

• Community-led adaptation of SBIRT for alcohol in AI/AN tribal primary care

  A community-driven effort will adapt and implement a brief alcohol intervention program (SBIRT) in tribal primary care to reduce unhealthy drinking among AI/AN adults.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11439986

• Alcohol Use Disorder Care in Primary Care: Making Treatment Easier and More Effective

  A primary care-based program helps people with alcohol use disorder get evidence-based medications and support over 12 weeks to improve drinking outcomes.

  NIH research Veterans Health Research Institute of Central New York, INC. · Syracuse, United States · NIH-11438214

• Insurer–Practice Integration in Primary Care for Older Adults in Medicare Advantage

  A physician-scientist is using AI to understand how insurer partnerships with primary care affect access and quality for older adults in Medicare Advantage.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11436453

• Team-based care to boost cervical cancer screening in low-resource clinics

  This grant tests a team-based approach in rural and under-resourced primary care clinics to help more people get screened for cervical cancer.

  NIH research University of Washington · Seattle, United States · NIH-11436066

• Nurses in primary care and their impact on patient outcomes in COPD and chronic disease

  A research project looks at how registered nurses in primary care affect care for adults with chronic diseases, including COPD.

  NIH research Emory University · Atlanta, United States · NIH-11434118

• Shared Decision Making for Depression Care in Primary Care

  A practical program to help adults with depression in primary care discuss treatment options with their doctors more clearly and together.

  NIH research Temple Univ of the Commonwealth · Philadelphia, United States · NIH-11431828

• Enhanced primary care telemedicine for kids with lung and airway infections

  A pediatric-focused telemedicine program is being studied to reduce unnecessary antibiotic use for common respiratory infections in children.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11425567

• Tech-enabled Aids to Help Older Adults Stay Independent

  A 3-year program tests a low-cost, group-based assistive technology approach to help adults 65+ stay independent by improving daily activities and quality of life in primary care clinics.

  NIH research University of Puerto Rico Med Sciences · San Juan, United States · NIH-11423709

• Private equity changes in primary care and Medicare outcomes

  This project studies how ownership of primary care practices by private equity firms may affect care quality and Medicare costs for people with chronic diseases.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11423388

• Single-Session Intervention to Help Adolescent Depression in Mozambican Clinics

  A one-visit intervention delivered by non-specialists aims to reduce depression symptoms for adolescents in Mozambican primary care, with implementation in real-world clinic settings.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11421506

• Weight Navigation Program to Help People with Obesity in Primary Care

  A new program in primary care helps adults with obesity get access to effective weight-loss options and stay on track using teamwork and remote weight monitoring.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11421462

• Connecting Primary Care to SUD Treatment with Telehealth Collaborative Care

  A Mayo Clinic study tests a telehealth-based collaborative care platform to help primary care clinics identify and treat substance use disorders in rural adults.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11421130

• HEARTS primary care program for hypertension and diabetes in Guatemala

  A study in Guatemala looks at how well the HEARTS approach can improve blood pressure and blood sugar care in primary clinics.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11420307

• ETUDES: Improving Care for Suicidal Youth in Pediatric Primary Care

  A center-led effort to help pediatric primary care teams better detect, triage, and manage suicidal thoughts and behaviors in teens.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11419715

• Improving Primary Care Workflow to Prevent HPV-Related Cancers

  Aimed at helping primary care clinics prevent HPV-related cancers in teens and young people by giving nurses and staff practical workflow upgrades.

  NIH research University of Rochester · Rochester, United States · NIH-11419564

Related topics

Quick answers

How many Primary Care clinical trials are recruiting right now?

13, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (4 trials), France (4 trials), Brazil (1 trial), Nepal (1 trial), United Kingdom (1 trial). Each study page lists its sites and which ones are recruiting.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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