Condition
Major Depressive Episode (MDE) clinical trials and research
As of November 12, 2026, Find a Trial lists 6 Major Depressive Episode (MDE) clinical trials that are recruiting, at sites in 3 countries (most in France (3), United States (2), Hong Kong (1)). 1 was first registered in the last 30 days. By phase: Phase 2 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 6Clinical trials
- 1New in 30 days
- 3Countries
Newest Major Depressive Episode (MDE) clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Understanding immune clues to depression in perimenopause | — | Grand Rapids, Michigan and 3 other locations | Recruiting | Nov 2, 2026 |
| Belief Update in Depression and Antidepressants in Older Adults | — | Rennes and 1 other locations | Recruiting | Jul 2, 2026 |
| TNX-102 SL taken at night for major depressive disorder | Phase 2 | Phoenix, Arizona and 26 other locations | Recruiting | Jun 2, 2026 |
| rTMS treatment for depression in adults with autism | — | Rennes | Recruiting | Dec 2, 2025 |
| Blood biomarker plus questionnaire test to help diagnose bipolar disorder | — | Montpellier | Recruiting | Jun 22, 2025 |
| Assessing mental health disorders in Hong Kong using a new recall method | — | Hong Kong | Recruiting | Feb 3, 2025 |
All recruiting trials (6)
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Understanding immune clues to depression in perimenopause
This study tests whether immune and epigenetic changes during perimenopause help explain why some women develop depression.
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Belief Update in Depression and Antidepressants in Older Adults
This study tests whether antidepressants change how older adults with major depressive disorder view the future and whether those belief changes relate to mood improvement.
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TNX-102 SL taken at night for major depressive disorder
A nighttime dose of TNX-102 SL is being tested to see if it helps adults with moderate to severe major depressive disorder compared to a placebo.
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rTMS treatment for depression in adults with autism
This trial will try repetitive transcranial magnetic stimulation (rTMS) and intermittent theta-burst stimulation (iTBS) to see if they reduce major depressive episodes in adults with autism spectrum disorder.
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Blood biomarker plus questionnaire test to help diagnose bipolar disorder
This trial will test whether a blood-based biomarker algorithm combined with the Mood Disorder Questionnaire (MDQ) can accurately identify adults with bipolar disorder who are currently experiencing a major depressive episode in primary care.
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Assessing mental health disorders in Hong Kong using a new recall method
This study is testing a new way to help people in Hong Kong remember important life events to see how many have experienced major depression and thoughts of suicide.
Related topics
Quick answers
How many Major Depressive Episode (MDE) clinical trials are recruiting right now?
6, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 3 countries. The most sites are in France (3 trials), United States (2 trials), Hong Kong (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.