Clinical trial Recruiting at 1 site Interventional Ages 18 to 70

Project CARE: Hereditary cancer risk checks in primary care

Official title: Project CARE: CAncer Risk Evaluation (CARE)

Run by Rutgers, The State University of New Jersey · NCT07130487 · Data updated 2026-11-12

This project will test whether sending primary care patients a chatbot link can identify people at high hereditary cancer risk and connect them to genetic counseling and testing.

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Quick facts

Study typeInterventional
Ages18 Years to 70 Years
SexAll
Enrollment210 (estimated)
SponsorRutgers, The State University of New Jersey
Academic / other
Locations1 site (New Brunswick, New Jersey)
StatusRecruiting
StartedNovember 19, 2025
Main results expectedNovember 2026
Study endsNovember 2026
Registry record updatedNovember 25, 2025
Trial IDNCT07130487 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are English-speaking adults aged 18–70 who received care in Rutgers family or general internal medicine within the past two years, have internet access and contact info in EPIC/MyChart, and no prior germline cancer testing or personal cancer history.

Probably not a fit

Patients with a personal history of cancer, prior germline genetic testing, dementia, no internet access, or who are not English speakers are unlikely to benefit from this outreach model.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Rutgers Health will use EPIC to identify adult patients seen in family medicine or general internal medicine and invite them by email or text to consent and use a Relational Agent (chatbot) through the patient portal for cancer risk questions and genetic education. The chatbot collects family and personal history to flag patients at high hereditary cancer risk, and those flagged will be offered genetic counseling and testing. The study will measure how many patients complete the chatbot, how many are identified as high risk, and uptake of genetic services, plus feasibility and patient acceptance of the proactive digital outreach. Recruitment is limited to English-speaking patients aged 18–70 with internet access who receive care at Rutgers primary care sites and have not had prior germline cancer testing or a personal cancer history.

Why it matters

Potential benefit: If successful, this approach could increase identification of people with hereditary cancer risk in primary care and streamline timely access to genetic counseling and testing.

How similar studies have gone: Digital risk tools and chatbot-based genetic education have shown promise in improving knowledge and uptake, but proactive, study-initiated outreach for hereditary cancer risk in primary care remains relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria

1. Age 18 to 70 years
2. Able to read and speak English
3. Have an email address or mobile phone number in EPIC and/or are enrolled in MyChart
4. Receiving health care in Family Medicine or General Internal Medicine at Rutgers Health within the past 2 years
5. Have not opted out of receiving research-related communications
6. Have internet access (via smartphone, tablet, or computer)

Exclusion Criteria

1. Dementia (e.g., Alzheimer's disease) as indicated in EPIC
2. Unable to access the Internet (via smartphone, tablet, or computer)
3. Previous germline genetic testing for hereditary cancer risk
4. Opted out of research participation in EPIC
5. Have a personal history of cancer

Where it's running

  • Rutgers, The State University of New Jersey
    New Brunswick, New Jersey, United States
    Recruiting

Study contacts

  • Principal investigator: Anita Y Kinney, PhD, RN — Rutgers, The State University of New Jersey
  • Study coordinator: Julie Chapman-Greene, PhD, MPH
  • Email: chapmaje@cinj.rutgers.edu
  • Phone: 732-865-3375

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.