Condition

Premature clinical trials and research

• 16Clinical trials
• 67NIH research projects
• 8Countries

Newest Premature clinical trials

All recruiting trials (16)

• Predicting Adverse Pregnancy Outcomes in Uganda through Partnerships and Innovation

  This study tests whether everyday health data, ultrasound, and blood samples from first-time pregnant women in Uganda can help predict problems like preeclampsia, fetal growth restriction, and preterm birth.

  Recruiting at 2 sites Makerere University · Kampala and 1 other locations · NCT07844876

• Breast milk and sugar solutions to ease heel-prick pain in premature babies

  This study tests whether oral breastfeeding or sugary solutions help relieve pain in premature newborns during a heel-prick blood draw.

  Recruiting Mersin University · Mersin · NCT07716813

• Gentle Touch and Sensory Changes to Ease Heel Pricks in Preterm Babies

  This study tests whether gentle human touch or a quiet, reduced-stimulation environment can reduce pain and improve comfort during heel blood collection for premature infants.

  Recruiting Baskent University · Ankara · NCT07715682

• Automated oxygen control for preterm babies on non-invasive support

  This trial tests whether closed-loop automated oxygen control helps preterm babies on non-invasive ventilation reach target oxygen levels more often and spend less time on supplemental oxygen compared with manual control.

  Recruiting King's College Hospital NHS Trust · London · NCT07622563

• Lung ultrasound to predict breathing problems in late‑preterm babies

  We will test whether early point‑of‑care lung ultrasound can predict which late‑preterm newborns will have breathing problems in the first 48 hours of life.

  Recruiting Hackensack Meridian Health · Hackensack, New Jersey · NCT07216053

• How the triglyceride–glucose (TyG) index relates to heart artery imaging in non‑diabetic adults with early coronary artery disease

  This study will see if the triglyceride–glucose (TyG) index helps explain angiographic patterns in non‑diabetic adults who develop coronary artery disease at younger ages.

  Recruiting Sohag University · Sohag · NCT07154186

• Lactase enzyme to reduce feeding problems in very preterm babies

  The team will try giving lactase enzyme to babies born before 32 weeks who start feeds in the first 72 hours to see if it prevents feeding intolerance in the NICU.

  Recruiting Alexandria University · Alexandria · NCT07088302

• NeoBellyBand abdominal support for premature infants on CPAP

  We will try the FDA-approved DandleLion NeoBellyBand on premature infants needing CPAP to see if it thickens their rectus abdominis muscle and helps them reach full oral feedings sooner.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07049900

• Evaluating methods to improve outcomes for premature babies through placental transfusion techniques

  This study is testing different ways to give blood from the placenta to premature babies to see which method helps them stay healthier in their first days of life.

  Recruiting Alexandria University · Alexandria · NCT06812507

• Effects of Skin-to-Skin Care on Premature Infants

  This study tests if regular skin-to-skin care for premature babies can help them get more of their mother's milk and reduce health problems before they go home from the hospital.

  Recruiting Baskent University Ankara Hospital · Ankara · NCT06672913

• Improving oral feeding in premature infants using a specific intervention

  This study is testing if a new feeding approach can help premature babies learn to eat on their own and breastfeed better before they leave the hospital.

  Recruiting Fundació Sant Joan de Déu · Barcelona, Catalonia · NCT06395298

• Understanding how nutrition affects growth in premature infants

  This study looks at how the food that premature babies eat in the NICU affects their growth and development over three years.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT06226051

• Using advanced magnetoencephalography to study brain development in newborns and adults

  This study is testing a new way to measure brain activity in healthy adults, term newborns, and premature infants to better understand how their brains develop.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT05835817

• Impact of DHA and ARA Supplementation on Preterm Infants

  This study tests if giving preterm infants a supplement of DHA and ARA right after birth can help improve their fat metabolism as they grow.

  Recruiting at 7 sites The University of Texas Health Science Center at San Antonio · Los Angeles, California and 6 other locations · NCT05380401

• Bacterial lysate treatment to prevent respiratory infections in preterm infants

  This study is testing if a bacterial treatment can help prevent respiratory infections and wheezing in preterm infants during their first year of life.

  Recruiting Phase 3 Franciscus Gasthuis · Rotterdam, South Holland · NCT05063149

• Using antibiotics to prolong pregnancy after premature rupture of membranes

  This study is testing if giving antibiotics to women with a premature rupture of membranes can help them keep their pregnancy going longer.

  Recruiting Phase 4 Woman's · Baton Rouge, Louisiana · NCT04047849

NIH-funded research (newest 40 of 67)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• How life circumstances affect brain aging in people with end-stage kidney disease

  This project looks at how neighborhood, income, education, and personal resilience relate to earlier memory and thinking problems in adults with end-stage kidney disease.

  NIH research New York University School of Medicine · New York, United States · NIH-11472074

• Mitigating HIV-Associated Premature Aging with Cannabinoids

  A doctor-scientist team is testing whether cannabis-based anti-inflammatory effects can slow aging-related brain changes in people living with HIV.

  NIH research Lsu Health Sciences Center · New Orleans, United States · NIH-11471052

• Megaplasmids and gut microbes in babies and adults

  Scientists are studying unusually large plasmids found in the gut bacteria of babies and adults to understand how these big DNA pieces might affect health and antibiotic resistance.

  NIH research University of California Berkeley · Berkeley, United States · NIH-11450672

• Metabolite-based approach to strengthen the premature gut

  A doctor-scientist team will test a metabolite and a synthetic version to help the immature intestines of very premature babies develop better defenses against NEC.

  NIH research University of Louisville · Louisville, United States · NIH-11437498

• Center to speed up proven health improvements for people with serious mental illness

  A Johns Hopkins-led center aims to bring already-proven heart-health interventions to adults with serious mental illness to cut their early deaths from heart disease.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11421405

• Antenatal steroids to boost lung health in premature babies in Bangladesh

  This project tests whether giving steroids before birth helps the lungs grow better in babies born very early in Bangladesh.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11420331

• Understanding how premature birth affects math skills and the brain

  This study looks at why children born early may have more trouble with math and how parents and the brain relate to those challenges.

  NIH research University of Iowa · Iowa City, United States · NIH-11416717

• AI-powered total parenteral nutrition for premature newborns

  A new AI-driven system aims to guide and personalize total parenteral nutrition for premature babies in NICUs to improve growth and health outcomes while reducing costs.

  NIH research Takeoff41, INC. · Portola Valley, United States · NIH-11412694

• Stool test to detect NEC early in premature babies

  A new stool-based test looks for DNA methylation signs of tissue injury to detect necrotizing enterocolitis early in preterm infants.

  NIH research Signature Diagnostics INC · Pittsburgh, United States · NIH-11409713

• Understanding why young men stop PrEP early so they stay protected

  A study to learn why men ages 18–35 stop taking PrEP before it’s needed and how to help them stay on it, with a focus on pills and injections.

  NIH research University of Connecticut Storrs · Storrs-Mansfield, United States · NIH-11408933

• Targeting aging pathways to help people living with HIV live longer, healthier lives

  A patient-centered research project aims to slow aging-related health problems in people with HIV by studying how aging mechanisms work and testing strategies to slow inflammation and aging.

  NIH research Northwestern University · Chicago, United States · NIH-11401327

• Prenatal pollution exposure and newborn lung injury risk

  This research looks at whether chemicals from polluted sites during pregnancy make preterm newborns more likely to develop serious lung disease.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11388581

• Premature aging in World Trade Center responders

  Researchers are studying whether responders to the 9/11 cleanup experience faster aging at a biological level, which could affect their health as they get older.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11387174

• Screening and treating early heart disease in young and middle-aged adults

  A large study will test the best way to find early artery disease in adults under 50 and whether treating arteries or inflammation helps reduce heart disease risk.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11382099

• Screening and treating early coronary plaque in young and middle-aged adults

  A Duke-led study will test how best to screen for early heart artery plaque in adults under 60 and how different treatments might reduce that plaque.

  NIH research Duke University · Durham, United States · NIH-11382094

• Colorimetric at-home test to detect premature rupture of membranes (PROM)

  A simple vaginal insert changes color to indicate the presence of amniotic fluid, helping detect PROM or preterm PROM early and at home.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11373861

• Prelamin A's link to early-onset and normal aging

  Researchers are looking to see if buildup of a protein called prelamin A drives bone loss and heart vessel disease in people with premature aging syndromes and in normal aging.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11370570

• Protecting the premature baby’s retina and lungs from oxygen damage

  Aims to safely shield the retina and other organs of very premature infants from oxygen-related injury while they receive oxygen therapy.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11348952

• AI-guided IV nutrition for premature newborns

  This project will use artificial intelligence to create standardized yet personalized IV nutrition (TPN) for premature babies in neonatal intensive care units.

  NIH research Takeoff41, INC. · Portola Valley, United States · NIH-11335827

• How sleep and brain activity in premature babies may relate to later development

  This project looks at whether patterns of sleep and brain activity in premature infants are linked with later developmental outcomes for those children.

  NIH research University of Iowa · Iowa City, United States · NIH-11327667

• How life circumstances affect memory and thinking in people with end-stage kidney disease

  Researchers will look at how social and economic factors relate to memory and thinking problems across adults with end-stage kidney disease.

  NIH research New York University School of Medicine · New York, United States · NIH-11326343

• Long-term immune and aging changes after severe pneumonia

  This project looks at lasting changes in gene activity and immune aging after severe pneumonia to understand why survivors face higher risks of heart disease, cancer, and repeat infections.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11311321

• Immune and cell‑aging changes in steroid‑resistant severe asthma

  This project looks at immune system changes and early cell aging in people whose severe asthma doesn't improve with steroid treatment to find new treatment ideas.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11292422

• How Zika infection before birth can cause early skull bone fusion in babies

  This project explains how Zika virus during pregnancy can cause early fusion of a baby's skull sutures and related developmental problems.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11249229

• Early-aging conditions and their link to artery disease

  This project looks for ways to stop early-aging from radiation or progeria from causing artery blockage and heart disease in cancer survivors and people with progeria.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11228780

• Collecting biospecimens from premature infants to improve sepsis detection

  This study is looking at samples from premature babies to learn more about sepsis, a serious infection they can get, so we can find better ways to spot it and help them stay healthy.

  NIH research Inova Health Care Services · Fairfax, UNITED STATES · NIH-11201133

• Detecting early aging in people with schizophrenia

  This work looks for blood and brain markers that show early aging in people with schizophrenia.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11195241

• Online and phone parenting support for toddlers born very premature

  This project compares online lessons, phone coaching, and a combination of both to help parents of toddlers born very prematurely reduce early behavior problems like aggression and defiance.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11143743

• Understanding Stress in Preterm Infants and Their Mothers

  This project looks at how stress in the NICU affects both preterm babies and their mothers, focusing on changes in their DNA.

  NIH research Marquette University · Milwaukee, United States · NIH-11140364

• Protecting premature infants from oxygen-related harm

  This research aims to find a safe way to protect the eyes and other organs of severely premature infants from damage caused by necessary oxygen therapy.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11130045

• Understanding Gut Bacteria in Premature Babies

  This project looks at how antibiotics given to premature babies right after birth affect the helpful bacteria in their gut.

  NIH research University of California Berkeley · Berkeley, United States · NIH-11118883

• How fetal development affects adult skin cell health

  This study is looking at how the way skin cells develop in babies can affect skin health when they grow up, and it's for anyone interested in keeping their skin healthy as they age.

  NIH research Sanford Burnham Prebys Medical Discovery Institute · La Jolla, United States · NIH-11098526

• Identifying heart issues caused by premature ventricular contractions.

  This study is looking at how premature heartbeats, called PVCs, might affect heart health, especially in people with different heart conditions, and it aims to help doctors better understand and manage these heartbeats using special heart imaging techniques.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11095956

• IL-32 and premature aging in people living with HIV

  This work explores whether a blood protein called IL‑32 is linked to early aging problems like heart disease, weak bones, and frailty in people living with HIV.

  NIH research Centre Hospitalier de L'universite de Montreal (University of Montreal Hospital) · Montreal, Canada · NIH-11094103

• How sleep and movement in premature infants can predict their development.

  This study looks at how the sleep habits and movements of premature babies might help us understand their growth and development, using special tools to track their sleep patterns and behaviors.

  NIH research University of Iowa · Iowa City, United States · NIH-11091569

• Understanding Memory and Attention Changes in Trauma-Exposed Responders

  This project aims to understand how trauma, like the World Trade Center attack, might affect memory and attention in first responders as they get older.

  NIH research New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC · New York, United States · NIH-11080746

• How systemic racism affects cognitive aging in patients with end-stage renal disease

  This study is looking at how racism affects brain health in Black patients with severe kidney disease, aiming to understand why some people experience faster cognitive decline and how others manage to stay resilient, so we can find better ways to support their health.

  NIH research New York University School of Medicine · New York, United States · NIH-11080355

• Investigating how severe infections like pneumonia can lead to premature aging at the epigenetic level.

  This study is looking at how severe pneumonia might change your body's aging process over time, and it’s for people who have had a serious pneumonia infection; we want to see how these changes could affect your health in the long run.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11076825

• A handheld camera for screening eye diseases in newborns

  This study is working on a new, easy-to-use camera that takes clear pictures of the eyes of premature babies to help doctors quickly check for vision problems, making it simpler to get the care these little ones need.

  NIH research Retivue · Charlottesville, United States · NIH-11068765

• Understanding how mechanical stress leads to early calcification in bicuspid aortic valves

  This study is looking into why people with a bicuspid aortic valve, which is a heart condition where the valve has only two flaps instead of three, often develop calcium buildup, and it aims to find better ways to treat this issue.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-11066100

Related topics

Quick answers

How many Premature clinical trials are recruiting right now?

16, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (5 trials), Egypt (3 trials), Turkey (Türkiye) (3 trials), Spain (1 trial), Uganda (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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