Lactase enzyme to reduce feeding problems in very preterm babies

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Preterm infants born at or before 32 weeks who begin enteral feeding within 72 hours will be enrolled at Alexandria University Children's Hospital and given either a lactase enzyme preparation or a matching placebo. Clinical staff will administer the assigned treatment around feeds and monitor infants for signs of feeding intolerance and feeding progression while in the neonatal intensive care unit. Key eligibility excludes infants with major congenital abnormalities, known galactosemia, severe intrauterine growth restriction, delayed feeding beyond three days, or lack of parental consent. The intervention aims to determine whether supplemental lactase can reduce feeding intolerance in this high-risk neonatal population.

Why it matters

Who can join: the full rules

Inclusion criteria will be as follows:

* Preterm neonates ≤ 32 weeks gestational age.
* Start feeding in the first 72 hours of life. 8. Exclusion criteria

Patients with any of the following will be excluded:

1. Parental consent lacking/refusal.
2. Obvious major congenital abnormalities.
3. Infants more than 72 hours of age at the time of randomization.
4. Delayed introduction of feeding (beyond three days of life).
5. Known galactosemia.
6. Severe IUGR. -

Where it's running

• Marwa Mohamed Farag
  Alexandria, Egypt Recruiting

Study contacts

• Study coordinator: Marwa M Farag, PhD
• Email: d.marwa.farag@gmail.com
• Phone: 01288681788

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Predicting Adverse Pregnancy Outcomes in Uganda through Partnerships and Innovation

  This study tests whether everyday health data, ultrasound, and blood samples from first-time pregnant women in Uganda can help predict problems like preeclampsia, fetal growth restriction, and preterm birth.

  Recruiting at 2 sites Makerere University · Kampala and 1 other locations · NCT07844876

• Breast milk and sugar solutions to ease heel-prick pain in premature babies

  This study tests whether oral breastfeeding or sugary solutions help relieve pain in premature newborns during a heel-prick blood draw.

  Recruiting Mersin University · Mersin · NCT07716813

• Gentle Touch and Sensory Changes to Ease Heel Pricks in Preterm Babies

  This study tests whether gentle human touch or a quiet, reduced-stimulation environment can reduce pain and improve comfort during heel blood collection for premature infants.

  Recruiting Baskent University · Ankara · NCT07715682

• Automated oxygen control for preterm babies on non-invasive support

  This trial tests whether closed-loop automated oxygen control helps preterm babies on non-invasive ventilation reach target oxygen levels more often and spend less time on supplemental oxygen compared with manual control.

  Recruiting King's College Hospital NHS Trust · London · NCT07622563

• Lung ultrasound to predict breathing problems in late‑preterm babies

  We will test whether early point‑of‑care lung ultrasound can predict which late‑preterm newborns will have breathing problems in the first 48 hours of life.

  Recruiting Hackensack Meridian Health · Hackensack, New Jersey · NCT07216053

• How the triglyceride–glucose (TyG) index relates to heart artery imaging in non‑diabetic adults with early coronary artery disease

  This study will see if the triglyceride–glucose (TyG) index helps explain angiographic patterns in non‑diabetic adults who develop coronary artery disease at younger ages.

  Recruiting Sohag University · Sohag · NCT07154186

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.