How the triglyceride–glucose (TyG) index relates to heart artery imaging in non‑diabetic adults with early coronary artery disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational study of non‑diabetic patients with premature coronary artery disease confirmed by coronary angiography. Investigators will calculate the TyG index from fasting triglyceride and glucose levels and compare it with angiographic lesion patterns and severity. Patients with known diabetes, prior revascularization, severe liver/kidney dysfunction, malignancy, autoimmune or systemic inflammatory disease, or current triglyceride‑lowering therapy are excluded. The work is conducted at Sohag University and aims to link a low‑cost blood marker of insulin resistance to early atherosclerotic changes on angiography.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years old.
* Both sexes.
* Non-diabetic patients \[no history of diabetes, hemoglobin A1C (HbA1C) \< 6.5%, fasting glucose \< 126 mg/dL\].
* Confirmed diagnosis of coronary artery disease (CAD) by coronary angiography.

Exclusion Criteria:

* Known diabetes mellitus (type 1 or type 2).
* Previous history of coronary revascularization.
* Severe hepatic or renal dysfunction \[alanine transaminase (ALT)/aspartate aminotransferase (AST) ≥ 5× upper limit of normal (ULN), estimated glomerular filtration rate (eGFR)\< 30 mL/min/1.73 m²\].
* Malignant disease, autoimmune disease, or systemic inflammatory disorders.
* Current use of triglyceride-lowering medications.

Where it's running

• Sohag University
  Sohag, Egypt Recruiting

Study contacts

• Study coordinator: Remon S Adly, MD
• Email: remonsaleh@yahoo.com
• Phone: 00201221878986

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.