Condition

Posttraumatic Stress Disorder (PTSD) clinical trials and research

• 22Clinical trials
• 4NIH research projects
• 6Countries

Newest Posttraumatic Stress Disorder (PTSD) clinical trials

All recruiting trials (22)

• Deep Brain Reorienting for PTSD in Veterans

  This study tests whether Deep Brain Reorienting can help reduce PTSD symptoms in military veterans compared with usual care.

  Recruiting University of Alberta · Edmonton, Alberta · NCT07840417

• Trauma recovery options for veterans: comparing HRV biofeedback and present-centered therapy

  This trial tests whether Heart Rate Variability Biofeedback plus trauma-informed care helps veterans with PTSD and substance use issues more than present-centered therapy.

  Recruiting Phase 2/3 Coatesville VA Medical Center · Coatesville, Pennsylvania · NCT07756723

• CIDI 5.0 validation against SCID-5 for lifetime mental disorders in Hong Kong adults

  This study tests whether the CIDI 5.0 interview can reliably identify lifetime mental disorders in adults in Hong Kong by comparing it with the SCID-5 diagnostic interview.

  Recruiting The University of Hong Kong · Hong Kong · NCT07604753

• Two-week intensive outpatient trauma program for PTSD

  This program will test whether a two-week outpatient course combining Prolonged Exposure and EMDR reduces PTSD symptoms and improves functioning in adults with PTSD.

  Recruiting Oslo University Hospital · Oslo · NCT07565311

• Side-by-Side Testing of SPARCS and the Unified Protocol for Youth with Chronic Illness and Trauma

  This trial tests whether two trauma-focused therapies (SPARCS and the Unified Protocol) help kids and teens with chronic medical conditions feel less trauma-related distress and function better, delivered in group or individual formats.

  Recruiting Ann & Robert H Lurie Children's Hospital of Chicago · Chicago, Illinois · NCT07483333

• Metacognitive Therapy vs Cognitive-Behavioral Therapy for Anxiety Disorders

  This study asks people with generalized anxiety disorder, social anxiety disorder, or PTSD to share their experiences after trying metacognitive therapy or disorder-specific cognitive-behavioral therapy in a randomized trial.

  Recruiting Karolinska Institutet · Stockholm · NCT07382323

• Single-dose ayahuasca versus esketamine for PTSD

  This study will try a single dose of ayahuasca or esketamine to see if it quickly reduces symptoms in adults with PTSD.

  Recruiting Phase 2 University of Sao Paulo · Ribeirão Preto, São Paulo · NCT07317206

• Crisis Response Planning added to intensive Cognitive Processing Therapy to reduce suicide risk in PTSD

  We will test whether adding Crisis Response Planning to intensive Cognitive Processing Therapy helps reduce suicidal thoughts and behaviors in military members and veterans with PTSD.

  Recruiting Ohio State University · Fort Hood, Texas · NCT07238192

• Cognitive Apps for Life Management (CALM) to help Veterans with anger after TBI and PTSD

  This trial tests whether the CALM mobile app can help Veterans with TBI and PTSD reduce anger and improve daily functioning compared with an active control.

  Recruiting Duke University · Durham, North Carolina · NCT07227987

• Integrated care for PTSD: testing combined mind-body and talk therapies for Veterans

  This trial tests different combinations of mind-body and psychotherapy approaches to see which help Veterans with PTSD function better.

  Recruiting at 5 sites Veterans Medical Research Foundation · Little Rock, Arkansas and 4 other locations · NCT07220681

• An EMDR app for PTSD in people with substance dependence.

  This project will test whether an app-based autonomous EMDR program helps adults with PTSD who also have a substance use disorder.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT07146633

• Deciding whether PTSD therapy or tinnitus therapy should come first for people with both conditions.

  This project will try giving either PTSD therapy first then tinnitus therapy, or tinnitus therapy first then PTSD therapy, in veterans and active-duty adults with PTSD and bothersome chronic tinnitus to see which order helps more.

  Recruiting The University of Texas Health Science Center at San Antonio · San Antonio, Texas · NCT07106593

• Neurosensory account of anxiety and stress — experiment 2

  This trial tests whether a mild, noninvasive brain stimulation (tACS) tuned to each person's alpha rhythm can change brain activity and reduce anxious arousal and hypervigilance in adults with PTSD compared with sham and random-noise stimulation.

  Recruiting The University of Texas Health Science Center, Houston · Houston, Texas · NCT07079839

• Comparing weekly versus intensive cognitive processing therapy for pregnant women with PTSD

  This tests whether standard weekly cognitive processing therapy or an intensive five-day version delivered by telemedicine better helps pregnant women with PTSD.

  Recruiting University of Texas at Austin · Austin, Texas · NCT07060144

• Ketamine Infusions with Mindfulness Therapy for Chronic Pain and PTSD

  This pilot test checks if adding ketamine infusions to mindfulness-based therapy helps adults with both chronic pain and PTSD more than mindfulness therapy alone.

  Recruiting Phase 1/2 Queen's University · Kingston, Ontario · NCT07009158

• Massed Prolonged Exposure for PTSD and Substance Use

  This study tests whether giving Prolonged Exposure therapy in a massed format during intensive outpatient treatment helps adults with PTSD and substance use disorders reduce PTSD symptoms and days of substance use.

  Recruiting Rutgers, The State University of New Jersey · Jacksonville, Florida · NCT06968832

• Transdiagnostic metacognitive therapy versus disorder-specific cognitive-behavioral therapy for adult anxiety

  This tests whether transdiagnostic metacognitive therapy works better than disorder-specific cognitive-behavioral therapy for adults with generalized anxiety disorder, social anxiety disorder, or PTSD.

  Recruiting Karolinska Institutet · Stockholm · NCT06937892

• Assessing mental health disorders in Hong Kong using a new recall method

  This study is testing a new way to help people in Hong Kong remember important life events to see how many have experienced major depression and thoughts of suicide.

  Recruiting The University of Hong Kong · Hong Kong · NCT06804525

• Therapy for Opioid Use Disorder and PTSD

  This study is testing a new therapy called HOPE to see if it helps people with both opioid use disorder and PTSD feel better when combined with their current medication.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06641115

• Understanding how inflammation affects fear responses in PTSD

  This study is testing how short-term changes in the immune system affect fear responses in people with and without PTSD by giving them a vaccine or a placebo while they listen to sounds.

  Recruiting Phase 1 University of California, San Francisco · San Francisco, California · NCT06630884

• Investigating the brain mechanisms of PTSD

  This study is testing a new way to understand PTSD by looking at brain activity in people with PTSD and healthy volunteers while using a special type of brain stimulation.

  Recruiting The University of Texas Health Science Center, Houston · Houston, Texas · NCT05895006

• Using methylphenidate to treat PTSD and cognitive issues in veterans

  This study is testing whether a medication called methylphenidate can help veterans with PTSD and thinking problems feel better.

  Recruiting at 3 sites Phase 4 VA Office of Research and Development · Birmingham, Alabama and 2 other locations · NCT05776056

NIH-funded research (4)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Computationally mapping PTSD to better diagnosis and personalized care

  A research project uses computer tools to find brain-based patterns that could help diagnose PTSD more clearly and tailor treatments for Veterans and others with PTSD.

  NIH research Providence VA Medical Center · Providence, United States · NIH-11522578

• Targeted glucocorticoid-blocking medicine for Veterans with PTSD

  Veterans with PTSD will receive a selective glucocorticoid receptor blocker called CORT108297 to help reduce stress-related PTSD symptoms.

  NIH research Veterans Affairs Med Ctr San Francisco · San Francisco, United States · NIH-11249175

• Creating new ways to diagnose and treat PTSD

  This study is looking to make it easier to diagnose and treat PTSD by using smart computer tools to better understand the different symptoms people experience, which could lead to more personalized care for those affected.

  NIH research Providence VA Medical Center · Providence, United States · NIH-11070369

• Testing a new medication for veterans with PTSD

  This study is looking at how well a new medication called CORT108297 can help veterans with posttraumatic stress disorder (PTSD) by improving their body's stress response, and participants will take the medication and share how they're feeling throughout the trial.

  NIH research Veterans Affairs Med Ctr San Francisco · San Francisco, United States · NIH-11044036

Related topics

Quick answers

How many Posttraumatic Stress Disorder (PTSD) clinical trials are recruiting right now?

22, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (13 trials), Canada (3 trials), Sweden (2 trials), Hong Kong (2 trials), Brazil (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1, Phase 2: 1, Phase 1/2: 1, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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