Testing a new medication for veterans with PTSD
Phase IIa Trial of a Selective Glucocorticoid Receptor Antagonist in the Treatment ofVeterans with Posttraumatic Stress Disorder (PTSD)
This study is looking at how well a new medication called CORT108297 can help veterans with posttraumatic stress disorder (PTSD) by improving their body's stress response, and participants will take the medication and share how they're feeling throughout the trial.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Affairs Med Ctr San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11044036 on NIH RePORTER |
What this research studies
This research investigates the effectiveness of a new glucocorticoid receptor antagonist, CORT108297, in treating veterans suffering from posttraumatic stress disorder (PTSD). The study aims to recalibrate the body's stress response system by targeting the hypothalamus-pituitary-adrenal (HPA) axis, which is often dysregulated in PTSD. Participants will receive the medication and be monitored for improvements in their symptoms over the course of the trial. The approach builds on previous findings that showed promise with similar medications.
Who could benefit from this research
Good fit: Ideal candidates for this research are veterans diagnosed with chronic PTSD who do not have a history of traumatic brain injury.
Not a fit: Patients with PTSD who have a history of traumatic brain injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a new, effective treatment option for veterans with PTSD.
How similar studies have performed: Previous trials with glucocorticoid receptor antagonists have shown clinical benefits, indicating potential for success with this new approach.
Where this research is happening
San Francisco, United States
- Veterans Affairs Med Ctr San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Neylan, Thomas C — Veterans Affairs Med Ctr San Francisco
- Study coordinator: Neylan, Thomas C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.