Understanding how inflammation affects fear responses in PTSD

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of short-term immune system changes on fear processing in individuals with and without posttraumatic stress disorder (PTSD). Participants will receive either a typhoid vaccine or a placebo and undergo physiological measurements while listening to sounds, as well as complete psychological assessments. The research aims to uncover how inflammation influences fear responses, particularly in trauma-exposed individuals, to inform future treatments for PTSD. The study is conducted at the San Francisco VA Health Care System and involves four appointments for each participant.

Why it matters

Who can join: the full rules

Inclusion Criteria:

All Subjects:

1. Aged 18-65 years old
2. Trauma Exposed
3. Current PTSD/No history of PTSD

Exclusion Criteria:

1. Contraindications to typhoid vaccine
2. Conditions associated with inflammation
3. Pregnancy or plans to become pregnant in next three months

Where it's running

• San Francisco VA Health Care System
  San Francisco, California, United States Recruiting

Study contacts

• Principal investigator: Aoife O'Donovan, PhD — University of California, San Francisco
• Study coordinator: Aoife O'Donovan, PhD
• Email: aoife.odonovan@ucsf.edu
• Phone: 415-221-4810

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.