Condition

Persistent Atrial Fibrillation clinical trials and research

• 29Clinical trials
• 20Countries

Newest Persistent Atrial Fibrillation clinical trials

All recruiting trials (29)

• FARAFLEX Mapping and Pulsed Field Ablation for Atrial Fibrillation

  This trial tests the FARAFLEX Mapping and PFA System to see if it can safely help adults with drug-refractory paroxysmal or persistent atrial fibrillation.

  Recruiting at 13 sites Boston Scientific Corporation · Jonesboro, Arkansas and 12 other locations · NCT07575269

• Pulsed field ablation for atrial fibrillation in underrepresented minority patients

  This registry will test how well Boston Scientific pulsed field ablation works and how safe it is for Black, Hispanic, Asian, and other underrepresented adults with paroxysmal or persistent atrial fibrillation.

  Recruiting at 2 sites Icahn School of Medicine at Mount Sinai · New York, New York and 1 other locations · NCT07535268

• Left Atrial Appendage Occlusion and Rhythm Restoration in AF Patients

  This trial tests a combined procedure using the Volt PFA System and Amulet 2 to see if it safely and feasibly treats atrial fibrillation while also closing the left atrial appendage in adults with AF.

  Recruiting at 13 sites Abbott Medical Devices · Brussels, B CAP R and 15 other locations · NCT07523620

• Qidong Yixin Granules to prevent atrial fibrillation returning after ablation

  This trial tests whether taking Qidong Yixin Granules after catheter ablation can lower the chance of atrial fibrillation coming back within a year in adults with persistent AF.

  Recruiting Phase 4 Sir Run Run Shaw Hospital · Hangzhou and 4 other locations · NCT07508618

• FARAPULSE pulsed-field waveform treatment for paroxysmal and persistent atrial fibrillation

  This will test new pulsed electrical waveforms delivered by the FARAPULSE PFA system to treat adults with paroxysmal or persistent atrial fibrillation.

  Recruiting at 3 sites Boston Scientific Corporation · Split and 3 other locations · NCT07444320

• PVI Alone vs PVI Plus PWI and SVCI with PFA in Persistent AF

  This study tests whether adding posterior wall isolation and superior vena cava isolation to pulmonary vein isolation with pulsed-field ablation helps people with persistent atrial fibrillation stay in rhythm.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07405359

• Progressive Resistance Training First to Help AF and HFpEF Patients Feel Better

  This trial tests whether starting with progressive resistance training before aerobic exercise can improve exercise capacity and quality of life in people aged 60 and older who have atrial fibrillation and HFpEF.

  Recruiting Northwestern University · Chicago, Illinois · NCT07324772

• PFLotus shape-adaptive pulsed-field catheter for persistent atrial fibrillation

  This trial tests a shape-changing pulsed-field catheter (PFLotus) to perform pulmonary vein isolation plus linear ablation in adults with persistent atrial fibrillation.

  Recruiting The Third People's Hospital of Chengdu · Chengdu · NCT07301190

• Redo AF ablation using the Sphere-9 catheter and Affera system for recurrent paroxysmal and persistent atrial fibrillation

  The study will try the Sphere-9 catheter with the Affera ablation and mapping systems for adults who have symptomatic recurrent paroxysmal or persistent atrial fibrillation after one prior ablation.

  Recruiting at 24 sites Medtronic Cardiac Ablation Solutions · Birmingham, Alabama and 29 other locations · NCT07298473

• Lower versus standard amiodarone dose to keep normal heart rhythm after electrical cardioversion

  This study will test whether 100 mg/day of amiodarone can keep normal heart rhythm as well as 200 mg/day for people with persistent atrial fibrillation after electrical cardioversion while causing fewer side effects.

  Recruiting Phase 4 Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau · Barcelona · NCT07273994

• Optimized posterior wall ablation for persistent atrial fibrillation

  This study tests whether adding posterior wall ablation and electrogram-guided ablation to standard pulmonary vein isolation helps people with persistent atrial fibrillation who are having their first ablation.

  Recruiting Shanghai Chest Hospital · Shanghai · NCT07122336

• Arrhythmia mapping with a paddle-shaped multi-electrode catheter

  This test uses a new high-density multi-electrode catheter to see if it can safely map atrial and ventricular arrhythmias in adults having catheter mapping and ablation.

  Recruiting at 5 sites Biosense Webster, Inc. · Bruges and 4 other locations · NCT07116525

• Pulmonary vein isolation alone versus pulmonary vein isolation plus linear ablation for persistent atrial fibrillation

  This study will test whether adding linear ablation to pulmonary vein isolation using pulsed field ablation helps people with persistent atrial fibrillation stay in normal heart rhythm.

  Recruiting Boston Scientific Corporation · Beijing · NCT07106970

• Pulsed field ablation versus cryoballoon ablation for persistent atrial fibrillation

  This study will test whether pulsed field ablation or cryoballoon ablation better restores and keeps a normal heart rhythm in adults with persistent atrial fibrillation.

  Recruiting Kitasato University · Sagamihara, Kanagawa · NCT07064616

• Pulsed-field ablation for persistent atrial fibrillation: a multicenter study with implantable monitor follow-up

  Researchers test pulsed-field ablation to treat symptomatic persistent atrial fibrillation and track recurrences with an implantable monitor across multiple centers.

  Recruiting Centre Hospitalier Universitaire de Nice · Nice · NCT06985901

• Pulmonary vein isolation plus box isolation of fibrotic areas using the Globe pulsed field system for symptomatic paroxysmal or persistent atrial fibrillation

  This trial will test whether using the Globe pulsed field system to perform pulmonary vein isolation plus box isolation of fibrotic areas helps people with symptomatic paroxysmal or persistent atrial fibrillation stay free of arrhythmia over 12 months.

  Recruiting Kardium Inc. · Kaiserslautern · NCT06973031

• Posterior mitral line with Vein of Marshall ethanolization vs anterior mitral lines for persistent atrial fibrillation

  This study tests whether a posterior mitral line with Vein of Marshall ethanol infusion works better than an anterior mitral line for people with persistent atrial fibrillation.

  Recruiting AZ Sint-Jan AV · Bruges · NCT06962176

• Mapping the heart's electrical signals in patients with persistent atrial fibrillation

  This study is testing a new mapping system to see if it can help doctors better treat patients with ongoing atrial fibrillation by guiding a tailored heart procedure.

  Recruiting CoreMap Inc. · Naples, Florida and 3 other locations · NCT06529978

• Evaluating a new catheter for treating persistent atrial fibrillation

  This study is testing a new catheter to see if it can safely help people with persistent atrial fibrillation who haven't found relief from other treatments.

  Recruiting at 4 sites Boston Scientific Corporation · Brussels and 3 other locations · NCT06510556

• Comparing two techniques for treating persistent atrial fibrillation

  This study is testing two different ways to treat ongoing atrial fibrillation to see which method works better at keeping heart rhythms steady.

  Recruiting AZ Sint-Jan AV · Bruges · NCT06383975

• Ablation and Isolation for Persistent Atrial Fibrillation Treatment

  This study is testing a new two-step treatment for long-lasting atrial fibrillation to see if it works better than the standard method and helps patients need fewer medications.

  Recruiting Barts & The London NHS Trust · London · NCT06165510

• Comparing cardioversion and ablation for persistent atrial fibrillation

  This study is testing whether a heart procedure called catheter ablation works better than a shock treatment to keep people with persistent atrial fibrillation from having their heart rhythm go out of sync again.

  Recruiting Barts & The London NHS Trust · London · NCT06096246

• Effect of heart procedure on thinking skills in older adults with mild cognitive impairment

  This study is testing if a heart procedure combined with medication can help improve thinking skills in older adults with mild cognitive impairment.

  Recruiting at 7 sites Poitiers University Hospital · Angers and 7 other locations · NCT05790707

• Comparing atrioventricular junction ablation and medication for patients with heart failure and atrial fibrillation

  This study is testing whether a procedure called atrioventricular junction ablation can help people with heart failure and atrial fibrillation feel better compared to just using medication.

  Recruiting at 9 sites University Hospital Ostrava · Liberec, Liberec Region and 8 other locations · NCT05776797

• Comparing two methods for treating persistent atrial fibrillation

  This study is testing whether a new treatment method for persistent atrial fibrillation works better than the standard approach for patients who haven't found relief with medication.

  Recruiting Hospital Clinic of Barcelona · Barcelona · NCT05723536

• Hybrid ablation for treating persistent atrial fibrillation

  This study is testing a new hybrid treatment for people with persistent atrial fibrillation to see if it works better than the standard catheter procedure in helping them stay free from heart rhythm problems.

  Recruiting at 5 sites St. George's Hospital, London · Chertsey and 6 other locations · NCT05411614

• Comparing two procedures for treating persistent atrial fibrillation after failed electric cardioversion

  This study is testing which of two procedures works better for patients with persistent atrial fibrillation who haven't had success with electric cardioversion.

  Recruiting at 6 sites Elsan · Caluire-et-Cuire and 12 other locations · NCT05264831

• Real-world experience of catheter ablation for atrial fibrillation

  This study is trying to see how well catheter ablation works for treating atrial fibrillation in real-life settings and what the outcomes are for patients over time.

  Recruiting at 70 sites Heart Rhythm Clinical and Research Solutions, LLC · Birmingham, Alabama and 74 other locations · NCT04088071

• Treatment of persistent atrial fibrillation using specialized devices during heart surgery

  This study tests if special devices used during heart surgery can safely help people with persistent atrial fibrillation feel better.

  Recruiting at 7 sites Medtronic Cardiac Surgery · Palo Alto, California and 14 other locations · NCT03546374

Related topics

Quick answers

How many Persistent Atrial Fibrillation clinical trials are recruiting right now?

29, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 20 countries. The most sites are in United States (8 trials), Belgium (7 trials), Czechia (6 trials), France (5 trials), Spain (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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