Comparing cardioversion and ablation for persistent atrial fibrillation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research investigates whether pulmonary vein isolation through catheter ablation leads to lower rates of atrial fibrillation (AF) recurrence compared to direct current (DC) cardioversion in patients with persistent AF. The study will involve a blinded, randomized trial design to compare the effectiveness of these two treatment strategies. Patients will be monitored for AF recurrence and other outcomes following their assigned treatment. The trial aims to provide clarity on the optimal first-line treatment for persistent AF, which has not been established in previous studies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Ability to give informed consent
* Age 18-85 years
* Persistent AF (atrial fibrillation lasting \> 7days) of total continuous duration \<2 years as documented in medical notes.
* Patients being considered for cardioversion.

Exclusion Criteria:

* Creatinine clearance (eGFR) \< 30mls/min
* Contraindication or unable to take anticoagulation
* Uncontrolled hypertension
* Contraindication for catheter ablation
* BMI \> 40
* Patients in Persistent AF who have had more than one previous cardioversion.
* Established diagnosis of Hypertrophic cardiomyopathy

Where it's running

• Barts Heart Centre
  London, United Kingdom Recruiting

Study contacts

• Principal investigator: Malcolm Finlay — Barts & The London NHS Trust
• Study coordinator: Malcolm Finlay, FRCP PhD
• Email: malcolm.finlay1@nhs.net
• Phone: 02037658635

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.