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Real-world experience of catheter ablation for atrial fibrillation

Real-world Experience of Catheter Ablation for the Treatment of Symptomatic ParoxysmaL and Persistent Atrial Fibrillation Using Novel CARTO Technologies: REAL AF Registry

Observational Heart Rhythm Clinical and Research Solutions, LLC · NCT04088071

This study is trying to see how well catheter ablation works for treating atrial fibrillation in real-life settings and what the outcomes are for patients over time.

Quick facts

Study typeObservational
Enrollment15000 (estimated)
Ages18 Years and up
SexAll
SponsorHeart Rhythm Clinical and Research Solutions, LLC Academic / other
Locations66 sites (Birmingham, Alabama and 65 other locations)
Trial IDNCT04088071 on ClinicalTrials.gov

What this trial studies

This registry aims to gather real-world clinical data on the use of radiofrequency catheter ablation technologies for treating Paroxysmal and Persistent Atrial Fibrillation. It is an observational, prospective, multi-center registry that will assess clinical outcomes such as procedural efficiency, safety, and long-term effectiveness of the ablation procedures. Patient evaluations will occur at multiple time points, including pre-ablation, during the procedure, and at follow-up intervals of 10-12 weeks, 6 months, and 1 year post-ablation. The registry will also include assessments of complications and arrhythmia recurrence.

Who should consider this trial

Good fit: Ideal candidates for this registry are adults aged 18 and older with symptomatic Paroxysmal or Persistent Atrial Fibrillation who are considered suitable for ablation.

Not a fit: Patients with long-standing persistent Atrial Fibrillation or those enrolled in other investigational trials may not benefit from this registry.

Why it matters

Potential benefit: If successful, this registry could provide valuable insights into the effectiveness and safety of catheter ablation for patients with atrial fibrillation.

How similar studies have performed: Other studies have shown success with similar observational approaches in assessing catheter ablation outcomes, indicating that this methodology is well-established.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Symptomatic Paroxysmal (AF episode terminate spontaneously within 7 days) or Persistent (AF sustained beyond 7 days) who, in the opinion of the investigator, are candidates for ablation for AF
* 18 years of age or older
* De Novo ablation procedure unless it is a repeat for a patient whose index procedure is also in the registry
* Able and willing to participate in baseline and follow up evaluations for the full length of the registry
* Willing and able to provide informed consent, if applicable

Exclusion Criteria:

* Enrolled in an investigational drug or device clinical trial, or any trial that dictates the treatment plan
* Long-standing persistent AF (AF greater than one year's duration)
* Having a repeat ablation, unless the subject's index ablation procedure is also included in the registry
* In the opinion of the investigator, any known contraindication to an ablation procedure

Where this trial is running

Birmingham, Alabama and 65 other locations

+16 more sites — see ClinicalTrials.gov for the full list.

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Paroxysmal Atrial FibrillationPersistent Atrial Fibrillation
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.