Comparing two techniques for treating persistent atrial fibrillation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to compare two different ablation techniques for patients suffering from persistent atrial fibrillation, a condition characterized by irregular and rapid heart rhythms. One technique uses pulsed field energy to create scars in the heart, while the other employs traditional radiofrequency ablation. Participants will undergo one of these procedures and will be monitored for one year to assess the effectiveness of each method in preventing the recurrence of atrial fibrillation. Regular check-ups and heart rhythm monitoring will be conducted to gather data on the outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Symptomatic persistent atrial fibrillation (AF) despite a first PVI. Persistent AF is defined as the presence of AF lasting ≥7 days (i.e. in case of new onset AF one has to wait for 7 days)

Exclusion Criteria:

* Persistent AF lasting ≥ 12 months
* Advanced valvular heart disease
* Left atrial (LA) volume \>150mL
* LA diameter (PS-LAX) \>60mm
* Septal wall diameter \>15mm
* Life expectancy \<1 year
* Weight \>150 kg
* Any contra indication to catheter ablation

Where it's running

• AZ Sint-Jan Brugge AV
  Bruges, Belgium Recruiting

Study contacts

• Principal investigator: Sébastien Knecht, MD, PhD — AZ Sint-Jan Brugge AV
• Study coordinator: Emma Christiaen
• Email: emma.christiaen@azsintjan.be
• Phone: 003250453293

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• FARAFLEX Mapping and Pulsed Field Ablation for Atrial Fibrillation

  This trial tests the FARAFLEX Mapping and PFA System to see if it can safely help adults with drug-refractory paroxysmal or persistent atrial fibrillation.

  Recruiting at 13 sites Boston Scientific Corporation · Jonesboro, Arkansas and 12 other locations · NCT07575269

• Pulsed field ablation for atrial fibrillation in underrepresented minority patients

  This registry will test how well Boston Scientific pulsed field ablation works and how safe it is for Black, Hispanic, Asian, and other underrepresented adults with paroxysmal or persistent atrial fibrillation.

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• Left Atrial Appendage Occlusion and Rhythm Restoration in AF Patients

  This trial tests a combined procedure using the Volt PFA System and Amulet 2 to see if it safely and feasibly treats atrial fibrillation while also closing the left atrial appendage in adults with AF.

  Recruiting at 13 sites Abbott Medical Devices · Brussels, B CAP R and 15 other locations · NCT07523620

• Qidong Yixin Granules to prevent atrial fibrillation returning after ablation

  This trial tests whether taking Qidong Yixin Granules after catheter ablation can lower the chance of atrial fibrillation coming back within a year in adults with persistent AF.

  Recruiting Phase 4 Sir Run Run Shaw Hospital · Hangzhou and 4 other locations · NCT07508618

• FARAPULSE pulsed-field waveform treatment for paroxysmal and persistent atrial fibrillation

  This will test new pulsed electrical waveforms delivered by the FARAPULSE PFA system to treat adults with paroxysmal or persistent atrial fibrillation.

  Recruiting at 3 sites Boston Scientific Corporation · Split and 3 other locations · NCT07444320

• PVI Alone vs PVI Plus PWI and SVCI with PFA in Persistent AF

  This study tests whether adding posterior wall isolation and superior vena cava isolation to pulmonary vein isolation with pulsed-field ablation helps people with persistent atrial fibrillation stay in rhythm.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07405359

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.