Understanding how hormonal changes during perimenopause affect depression.
The immunobiological mechanisms of depression in perimenopause
This study is looking at how hormonal changes during perimenopause might affect the immune system and contribute to depression in women, with the goal of finding new ways to help those who are feeling down during this time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Van Andel Research Institute NIH-funded |
| Lab location | 1 site (Grand Rapids, United States) |
| Project ID | NIH-11072385 on NIH RePORTER |
What this research studies
This research investigates the biological mechanisms that may lead to depression in women during the perimenopausal phase, a time marked by significant hormonal fluctuations. The study focuses on how these hormonal changes can influence immune responses, particularly in T-cells, which may contribute to the onset or worsening of depressive symptoms. By analyzing specific immune markers and genetic modifications, the research aims to uncover the links between hormonal shifts and depression, potentially leading to new treatment strategies. Women experiencing perimenopause may be monitored for changes in their immune profiles and depressive symptoms throughout the study.
Who could benefit from this research
Good fit: Ideal candidates for participation are women experiencing perimenopause who have a history of depression.
Not a fit: Patients who are not in the perimenopausal stage or do not have a history of depression may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for depression in perimenopausal women.
How similar studies have performed: Previous research has shown promising results in understanding the immune response in relation to depression, suggesting that this approach may yield valuable insights.
Where this research is happening
Grand Rapids, United States
- Van Andel Research Institute — Grand Rapids, United States (Active)
Researchers
- Principal investigator: Brundin, Lena Cecilia — Van Andel Research Institute
- Study coordinator: Brundin, Lena Cecilia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.