Air program for perimenopause symptoms

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial compares the Amygdala and Insula Retraining (AIR) program to a wait-list control in adults experiencing perimenopausal symptoms. It is a parallel-group, randomized design with 1:1 allocation and remote delivery, lasting 24 weeks. Eligible participants are ages 38 to 60 who have perimenopausal symptoms and meet STRAW+10 criteria, and have internet access in order to participate. The study includes a 12-week AIR intervention with immediate access for the treatment group and a 12-week wait-list phase for controls, followed by access to AIR after completion. Exploratory wearable measures, such as heart rate variability, are used to examine potential links between symptom changes and autonomic regulation and sleep.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Experiencing perimenopausal symptoms
* Meets STRAW+10 criteria based on self-assessment (-2 to +1c)
* Able to read and understand English
* Access to internet

Exclusion Criteria:

* Pregnancy
* Presence of a severe psychiatric condition requiring immediate clinical intervention
* Uncontrolled thyroid disease or prolactinoma
* Active cancer treatment
* Inability to provide informed consent
* Any medical or psychiatric condition that, in the judgment of the investigator or study team, would interfere with safe participation or study completion

Where it's running

• Luther College Department of Psychology
  Decorah, Iowa, United States Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.