Understanding Brain Changes in Perimenopause and Psychosis
Aberrant dopamine system function in a rodent model of perimenopause: relevance to psychosis
This project explores how brain changes during perimenopause might lead to psychosis and seeks new ways to help women experiencing these symptoms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-11106007 on NIH RePORTER |
What this research studies
Many women experience an increased risk of psychosis or worsening existing conditions like bipolar disorder during perimenopause. Current medications for psychosis are not always effective and can have difficult side effects, especially for women in this life stage. This research aims to understand how specific brain systems, particularly dopamine, are affected during perimenopause and contribute to psychosis symptoms. By studying these brain changes, we hope to find better ways to restore normal brain function and develop more effective treatments.
Who could benefit from this research
Good fit: This research is relevant for women experiencing or at risk of psychosis during the perimenopausal transition.
Not a fit: Patients whose psychosis is unrelated to perimenopause or hormonal changes may not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could lead to new and more effective treatments for psychosis symptoms experienced by women during perimenopause, with fewer side effects.
How similar studies have performed: This research builds upon existing knowledge of dopamine system dysfunction in psychosis and aims to identify novel therapeutic targets specific to perimenopausal women.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Perez, Stephanie Marie — University of Texas Hlth Science Center
- Study coordinator: Perez, Stephanie Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.