Understanding treatment outcomes for older adults with overactive bladder
Official title: Risk determination and prognostication for older and frail older adults undergoing advanced treatments for overactive bladder
Funded at University of California, San Francisco · NIH-11073108 · Data updated 2026-11-12
This study is looking at how older adults with overactive bladder respond to different advanced treatments, like injections and nerve stimulation, to find out what works best for them and to help doctors make better choices for their care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | April 15, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $418,092 |
| NIH project number | 5R01AG082642-02 |
| Project ID | NIH-11073108 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults aged 65 and above who are experiencing refractory overactive bladder.
✕Less likely to help
Patients under the age of 65 or those without overactive bladder may not benefit from this research.
What this research studies
This research investigates how older and frail adults respond to advanced treatments for overactive bladder, including onabotulinumtoxinA, peripheral tibial nerve stimulation, and sacral neuromodulation. The study aims to identify the effectiveness and potential complications of these treatments specifically in this vulnerable population, which has been underrepresented in previous studies. By analyzing treatment outcomes, the researchers hope to develop a personalized prognostic tool that can guide clinicians in making better treatment decisions for older patients. This approach seeks to ensure that older adults receive appropriate care tailored to their unique health needs.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies and outcomes for older adults suffering from overactive bladder.
How similar studies have gone: While there has been extensive research on these treatments in younger populations, this study addresses a significant gap in knowledge regarding older adults, making it a novel approach.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Suskind, Anne M. — University of California, San Francisco
- Study coordinator: Suskind, Anne M.
Related research
Other NIH-funded projects on the same topics.
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Microneedle delivery of Trospium for better tolerance in overactive bladder
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Alternatives to Step Therapy for Overactive Bladder in Older Adults
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Culturally tailored AI-assisted digital therapy for bladder symptoms in Black women
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Predicting risks and outcomes of advanced overactive bladder treatments for older adults
This project will build a tool to predict which third-line treatments for overactive bladder are likely to help or harm older and frail adults.
-
Personalized brain stimulation for overactive bladder in multiple sclerosis
This research uses targeted, noninvasive brain stimulation to try to reduce urinary urgency, frequency, and leakage in women with multiple sclerosis.
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Long-lasting bladder treatment for urinary leaks and urgency in older adults
This project is creating bladder-instilled medicines that aim to give months of relief from urinary leaks and urgent urges in older adults who haven't been helped by current treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.