Microneedle delivery of Trospium for better tolerance in overactive bladder
Official title: Microneedle delivery of Trospium Chloride optimized for improved tolerance and patient outcomes in overactive bladder disease
Funded at Tsrl, INC. · NIH-11416409 · Data updated 2026-11-12
A tiny, painless microneedle patch is being developed to deliver Trospium chloride more comfortably for people with overactive bladder.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tsrl, INC. NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 19, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $1,097,498 |
| NIH project number | 5R44DK143799-03 |
| Project ID | NIH-11416409 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with overactive bladder who are prescribed Trospium or candidates for anticholinergic therapy.
✕Less likely to help
Patients who cannot use microneedle patches or have contraindications to Trospium may not benefit.
What this research studies
This project aims to improve how Trospium is given to people with overactive bladder by using a microneedle delivery system. The goal is to achieve steady drug levels with fewer side effects and better patient tolerance. If successful, patients may experience fewer breaks in treatment and better quality of life due to less cognitive and skin-related issues seen with current therapies.
Why it matters
Potential benefit: Potentially fewer side effects and better adherence to treatment for people with overactive bladder.
How similar studies have gone: Past similar approaches (e.g., adhesive patches) reduced side effects but introduced other challenges; this study builds on those ideas with a new delivery method.
Where this research is happening
-
Tsrl, INC.
Ann Arbor, United States Active
Researchers
- Principal investigator: Lipka, Elke — Tsrl, INC.
- Study coordinator: Lipka, Elke
Related research
Other NIH-funded projects on the same topics.
-
Alternatives to Step Therapy for Overactive Bladder in Older Adults
This grant explores simpler, patient-centered ways to treat overactive bladder in people 65 and older, to help them get effective care faster.
-
Culturally tailored AI-assisted digital therapy for bladder symptoms in Black women
A new AI-powered app called CeCe helps Black women learn about overactive bladder and manage its symptoms with education and coaching.
-
Predicting risks and outcomes of advanced overactive bladder treatments for older adults
This project will build a tool to predict which third-line treatments for overactive bladder are likely to help or harm older and frail adults.
-
Personalized brain stimulation for overactive bladder in multiple sclerosis
This research uses targeted, noninvasive brain stimulation to try to reduce urinary urgency, frequency, and leakage in women with multiple sclerosis.
-
Long-lasting bladder treatment for urinary leaks and urgency in older adults
This project is creating bladder-instilled medicines that aim to give months of relief from urinary leaks and urgent urges in older adults who haven't been helped by current treatments.
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Microneedle patch to deliver trospium for overactive bladder
A tiny microneedle patch that delivers the bladder medicine trospium aims to reduce side effects and improve symptom control for people with overactive bladder.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.