How bladder sensations during filling relate to overactive bladder in people with multiple sclerosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional protocol uses repeated cystometries (urodynamic tests) while recording patients' reported bladder sensations at key filling points, and may include bladder diaries to capture sensation intensity. Participants are adults with multiple sclerosis and bladder symptoms who are not currently taking bladder medications and can undergo urodynamic testing. The goal is to correlate sensation patterns (increased, decreased, or normal) with the severity of overactive bladder symptoms and to distinguish sensation-driven problems from detrusor overactivity. People with recent MS relapse, other neurological disease, pregnancy, recent bladder treatments, or inability to use the sensation-recording device are excluded.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18
* MS according to the 2017 Mac Donald diagnostic criteria
* Bladder disorders supposedly related to MS
* Indication to perform urodynamics
* No current medication for bladder disorders
* Able to understand and right in French
* Affiliated to the "Securite sociale" or "Couverture Medicale Universelle (CMU)", or equivalent organism.

Exclusion criteria:

* Legal protection
* Pregnancy or breastfeeding mother
* MS relapse during the past month
* Other associated neurological disease
* Genuine stress incontinence related to postpartum
* Treatment with antimuscarinics, alpha blockers, beta3 adrenergic, or tibial nerve stimulation in the past 15 days, or with botulinic toxin injection in the past 6 months
* Previous lower urinary tract surgery
* Inability to use the analogic device due to motor, sensory or ataxic disabilities

Where it's running

• Hôpital TENON
  Paris, Choisir Une Région, France Recruiting

Study contacts

• Study coordinator: Claire Hentzen, MD
• Email: claire.hentzen@aphp.fr
• Phone: 0156017500

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.