Understanding treatment outcomes for older adults with overactive bladder
Official title: Determinants of outcomes for older and frail older adults with refractory overactive bladder
Funded at University of California, San Francisco · NIH-10912086 · Data updated 2026-11-12
This study is looking at how older adults with overactive bladder respond to new treatments, like injections and nerve stimulation, to find out which options work best and are safest for them, so they can get the right care for their needs.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 15, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $474,043 |
| NIH project number | 1R56AG076501-01A1 |
| Project ID | NIH-10912086 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older and frail adults experiencing refractory overactive bladder.
✕Less likely to help
Patients who are younger or do not have overactive bladder may not benefit from this research.
What this research studies
This research investigates how older and frail adults respond to advanced treatments for overactive bladder, specifically focusing on therapies like onabotulinumtoxinA, peripheral tibial nerve stimulation, and sacral neuromodulation. The study aims to identify the effectiveness and potential complications of these treatments in this vulnerable population, which has been underrepresented in previous research. By analyzing treatment outcomes, the researchers hope to develop a personalized prognostic tool that can guide better treatment decisions for older patients. This approach seeks to ensure that older adults receive appropriate care tailored to their specific health needs.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and outcomes for older adults suffering from overactive bladder.
How similar studies have gone: Previous research has shown success in understanding treatment outcomes in younger populations, but this approach is novel for older adults.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Suskind, Anne M. — University of California, San Francisco
- Study coordinator: Suskind, Anne M.
Related research
Other NIH-funded projects on the same topics.
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Microneedle delivery of Trospium for better tolerance in overactive bladder
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Alternatives to Step Therapy for Overactive Bladder in Older Adults
This grant explores simpler, patient-centered ways to treat overactive bladder in people 65 and older, to help them get effective care faster.
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Culturally tailored AI-assisted digital therapy for bladder symptoms in Black women
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Predicting risks and outcomes of advanced overactive bladder treatments for older adults
This project will build a tool to predict which third-line treatments for overactive bladder are likely to help or harm older and frail adults.
-
Personalized brain stimulation for overactive bladder in multiple sclerosis
This research uses targeted, noninvasive brain stimulation to try to reduce urinary urgency, frequency, and leakage in women with multiple sclerosis.
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Long-lasting bladder treatment for urinary leaks and urgency in older adults
This project is creating bladder-instilled medicines that aim to give months of relief from urinary leaks and urgent urges in older adults who haven't been helped by current treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.