Treatment for knee osteoarthritis using bone marrow aspirate concentrate

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot study investigates the safety and effectiveness of bone marrow aspirate concentrate (BMAC) in patients with moderate to severe knee osteoarthritis who are scheduled for total knee replacement. Patients will have bone marrow extracted from their pelvic region, concentrated using the Angel System, and then delivered back to the knee arthroscopically. The study will monitor adverse events and assess healing through physical exams and standardized questionnaires. The goal is to determine if BMAC can improve joint structure and alleviate pain.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Kellgren Lawrence radiographic grade IV
2. Need for a total knee arthroscopy by the patients primary care provider/or orthopedist.
3. Persistent pain in target knee that is unresponsive to standard of care including acetametaphine, non-steroidal anti-inflammatory drugs, physical therapy and/or intraarticular corticosteroids and/or hyaluronic acid preparations.
4. Males or females aged 45-75.

Exclusion Criteria:

\-

Where it's running

• University of California San Diego Koman Outpatient Pavilion
  La Jolla, California, United States Recruiting

Study contacts

• Study coordinator: Kenneth Kalunian, MD
• Email: kkalunian@health.ucsd.edu
• Phone: 858-246-2381

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Arthrosamid versus steroid injections for managing knee osteoarthritis.

  This trial will test whether a single Arthrosamid hydrogel injection works better than a standard steroid plus local anesthetic injection for adults with symptomatic knee osteoarthritis.

  Recruiting Phase 4 Cappagh National Orthopaedic Hospital · Dublin, Dublin · NCT07489521

• Platelet-rich plasma plus hyaluronic acid injections for knee osteoarthritis

  We will try a single injection of platelet-rich plasma plus hyaluronic acid, platelet-rich plasma alone, or hyaluronic acid alone to see which works best for adults (40–75) with unilateral knee osteoarthritis who still have pain after conservative treatment.

  Recruiting Istituto Ortopedico Rizzoli · Bologna and 1 other locations · NCT06685120

• Evaluating OA-SYS for knee osteoarthritis treatment

  This study is testing a new treatment called OA-SYS using adult stem cells to see if it can help people with moderate to severe knee osteoarthritis feel better and improve their knee function.

  Recruiting Phase 2 Ageless Biotech, Inc. · Las Vegas, Nevada · NCT06485843

• Using bioceramic materials to repair bone defects

  This study is testing if a new type of bioceramic implant can help people heal better from bone defects compared to a standard bone implant.

  Recruiting Nanjing First Hospital, Nanjing Medical University · Nanjing, Jiangsu · NCT06249906

• Evaluating Metformin for Knee Osteoarthritis

  This study is testing if Metformin can help people aged 30 to 60 with knee osteoarthritis feel better and improve their joint function compared to another medication.

  Recruiting Phase 3 Tanta University · Damietta, New Damietta · NCT06231758

• Comparing the effects of a vegan diet to an omnivorous diet before knee surgery

  This study is testing whether a vegan diet for two weeks before knee surgery can help older adults with knee osteoarthritis build protein in their muscles and tissues better than a regular diet with meat.

  Recruiting at 2 sites Wageningen University · Arnhem and 1 other locations · NCT06130956

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.