Examining fat tissue in the knee and thigh muscles of patients with osteoarthritis
Study to Compare the Characteristics of Hoffa Adipose Tissue and Intramuscular Adipose Tissue in the Quadriceps Muscle
This study looks at fat tissue in the knees and thigh muscles of people with knee osteoarthritis to see how it affects muscle strength and the progression of the condition.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 20 (estimated) |
| Ages | 40 Years to 85 Years |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire de Nice Academic / other |
| Locations | 1 site (Nice) |
| Trial ID | NCT05955976 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the characteristics of Hoffa adipose tissue and intramuscular adipose tissue in the quadriceps muscle of patients diagnosed with knee osteoarthritis. It aims to understand the relationship between skeletal muscle characteristics, particularly quadriceps weakness, and the progression of knee osteoarthritis. By analyzing tissue samples obtained through biopsy, the study seeks to uncover the mechanisms by which muscle and adipose tissue may influence the pathophysiology of osteoarthritis. The findings could provide insights into the role of muscle health in managing knee osteoarthritis.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 40 to 85 years who have a confirmed diagnosis of knee osteoarthritis and are scheduled for total knee prosthesis surgery.
Not a fit: Patients who do not have knee osteoarthritis or are outside the age range of 40 to 85 years may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management strategies for knee osteoarthritis by highlighting the importance of muscle health.
How similar studies have performed: While the specific approach of this study may be novel, there is growing interest in the relationship between muscle and osteoarthritis, suggesting potential for meaningful insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patient, aged between 40 and 85 years * Patient having a confirmed diagnosis of knee ostheoarthritis * Patient undergoing a surgery for a total knee prosthesis for knee ostheoarthritis Exclusion Criteria: -
Where this trial is running
Nice
- Nice University Hospital — Nice, France (Recruiting)
Study contacts
- Study coordinator: Christian ROUX, PUPH
- Email: roux.c2@chu-nice.fr
- Phone: 0492035491
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.