Comparing two methods of knee replacement surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to compare the clinical outcomes and accuracy of implant positioning between Mako robotic unicondylar knee arthroplasty and jig-based Oxford unicondylar knee arthroplasty with navigation control. Patients will be randomly assigned to receive either the Mako robotic procedure or the Oxford procedure. The primary objective is to assess the accuracy of component positioning using low radiation dose CT scans postoperatively. This study will help determine which surgical method provides better outcomes for patients with medial unicompartmental knee osteoarthritis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* • Patient has medial unicompartmental knee osteoarthritis requiring primary UKA

  * Patient and Surgeon are in agreement that UKA is the most appropriate treatment
  * Patient is fit for surgical intervention following review by surgeon and anaesthetist
  * Patient is between 40-80 years of age at time of surgery
  * Gender: male and female
  * Patient must be capable of giving informed consent and agree to comply with the postoperative review program
  * Patient must be a permanent resident in an area accessible to the study site
  * Patient must have sufficient postoperative mobility to attend follow-up clinics and allow for radiographs to be taken

Exclusion Criteria:

* • Patient is not suitable for primary UKA e.g. multi-compartmental knee osteoarthritis, anterior cruciate ligament rupture

  * Patient is not medically fit for surgical intervention
  * Patient requires revision surgery following previously failed correctional osteotomy or ipsilateral UKA
  * Patient is immobile or has another neurological condition affecting musculoskeletal function
  * Patient is less than 40 years of age or greater than 80 years of age
  * Patient is already enrolled on another concurrent clinical trial
  * Patient is unable or unwilling to sign the informed consent form specific to this study
  * Patient is unable to attend the follow-up programme
  * Patient is non-resident in local area or expected to leave the catchment area postoperatively

Where it's running

• UCL Hospital NHS Foundation Trust
  London, United Kingdom Recruiting

Study contacts

• Principal investigator: Babar Kayani — UCL Hospitals NHS Foundation Trust
• Study coordinator: Jenni Tahmassebi
• Email: jenni.tahmassebi1@nhs.net
• Phone: 02034479413

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Arthrosamid versus steroid injections for managing knee osteoarthritis.

  This trial will test whether a single Arthrosamid hydrogel injection works better than a standard steroid plus local anesthetic injection for adults with symptomatic knee osteoarthritis.

  Recruiting Phase 4 Cappagh National Orthopaedic Hospital · Dublin, Dublin · NCT07489521

• Platelet-rich plasma plus hyaluronic acid injections for knee osteoarthritis

  We will try a single injection of platelet-rich plasma plus hyaluronic acid, platelet-rich plasma alone, or hyaluronic acid alone to see which works best for adults (40–75) with unilateral knee osteoarthritis who still have pain after conservative treatment.

  Recruiting Istituto Ortopedico Rizzoli · Bologna and 1 other locations · NCT06685120

• Evaluating OA-SYS for knee osteoarthritis treatment

  This study is testing a new treatment called OA-SYS using adult stem cells to see if it can help people with moderate to severe knee osteoarthritis feel better and improve their knee function.

  Recruiting Phase 2 Ageless Biotech, Inc. · Las Vegas, Nevada · NCT06485843

• Using bioceramic materials to repair bone defects

  This study is testing if a new type of bioceramic implant can help people heal better from bone defects compared to a standard bone implant.

  Recruiting Nanjing First Hospital, Nanjing Medical University · Nanjing, Jiangsu · NCT06249906

• Evaluating Metformin for Knee Osteoarthritis

  This study is testing if Metformin can help people aged 30 to 60 with knee osteoarthritis feel better and improve their joint function compared to another medication.

  Recruiting Phase 3 Tanta University · Damietta, New Damietta · NCT06231758

• Comparing the effects of a vegan diet to an omnivorous diet before knee surgery

  This study is testing whether a vegan diet for two weeks before knee surgery can help older adults with knee osteoarthritis build protein in their muscles and tissues better than a regular diet with meat.

  Recruiting at 2 sites Wageningen University · Arnhem and 1 other locations · NCT06130956

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.