Condition

Metastatic Melanoma clinical trials and research

• 38Clinical trials
• 11NIH research projects
• 17Countries

Newest Metastatic Melanoma clinical trials

All recruiting trials (38)

• 30-minute cycling immediately before nivolumab and ipilimumab for metastatic melanoma

  This trial will test whether a 30-minute cycling session immediately before nivolumab plus ipilimumab boosts immune activity and improves outcomes for people with metastatic melanoma.

  Recruiting Universitätsklinikum Hamburg-Eppendorf · Hamburg, Free and Hanseatic City of Hamburg · NCT07564570

• Using ctDNA to decide whether to add ipilimumab for people on nivolumab and relatlimab

  This tests whether using a ctDNA blood test to guide adding ipilimumab for adults with advanced or metastatic melanoma on nivolumab and relatlimab leads to longer progression-free survival.

  Recruiting Phase 2 NYU Langone Health · New York, New York · NCT07504796

• First-line immunotherapy and PD-L1 testing for metastatic melanoma in Slovenia

  This study will see if first-line immunotherapy (pembrolizumab, nivolumab, or ipilimumab plus nivolumab) works for adults in Slovenia with metastatic melanoma and whether PD-L1 measurements predict who responds.

  Recruiting Institute of Oncology Ljubljana · Ljubljana · NCT07422779

• First-line immunotherapy for metastatic melanoma in Slovenia with biomarker identification

  This study will try first-line immunotherapy in adults with metastatic melanoma in Slovenia and collect blood, stool, and fluid samples to find markers linked to treatment response.

  Recruiting Institute of Oncology Ljubljana · Ljubljana · NCT07407166

• Morning versus afternoon immunotherapy for advanced or metastatic solid tumors

  This trial tests whether giving standard immune checkpoint inhibitor therapy in the morning versus the afternoon changes outcomes for adults with advanced or metastatic solid tumors.

  Recruiting Phase 4 OHSU Knight Cancer Institute · Portland, Oregon · NCT07405086

• HEPZATO KIT with Opdualag for metastatic melanoma that has spread to the liver

  This will try adding HEPZATO KIT to Opdualag (nivolumab + relatlimab) to see if it's safe and helps people with metastatic melanoma that has spread to the liver.

  Recruiting Phase 1/2 University of Wisconsin, Madison · Madison, Wisconsin · NCT07281924

• IL-17 Blockade to See if Restarting Immunotherapy is Safer in Metastatic Melanoma

  This study tests whether giving secukinumab before and during restarting PD-1–based therapy can help patients with metastatic melanoma who previously had immune-related side effects from immunotherapy.

  Recruiting Phase 1 Duke University · Durham, North Carolina · NCT07237594

• Mirdametinib for advanced NF1‑mutant melanoma

  This study tests whether the MEK inhibitor mirdametinib can slow or stop disease in people with advanced NF1‑mutant melanoma whose cancer progressed after prior immunotherapy.

  Recruiting Phase 2 Sutter Health · San Francisco, California · NCT07237100

• Focused radiotherapy to control a few growing melanoma spots

  This trial tries adding stereotactic or short-course radiotherapy to up to ten extracranial melanoma spots that are starting to grow while patients stay on their current systemic therapy to see if it delays overall disease progression.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07112170

• Adze1.C for people with metastatic melanoma

  This trial will try Adze1.C, a virus-based therapy injected directly into tumors, in adults with metastatic melanoma who have not responded to standard treatments.

  Recruiting at 3 sites Phase 1 Adze Biotechnology Inc · Southport, Queensland and 2 other locations · NCT07086105

• Investigating IOV-3001 for Advanced Melanoma Treatment

  This study is testing a new treatment called IOV-3001 to see if it can help adults with advanced melanoma who haven't been able to have surgery.

  Recruiting at 5 sites Phase 1/2 Iovance Biotherapeutics, Inc. · Denver, Colorado and 4 other locations · NCT06940739

• Long-term safety follow-up after RP1, RP2, or RP3 treatment

  This study will follow people with melanoma or other advanced solid tumors who previously received RP1, RP2, or RP3 to see if any delayed side effects appear over five years.

  Recruiting at 2 sites Replimune, Inc. · La Jolla, California and 1 other locations · NCT06887348

• A new method to detect melanoma cells in blood without surgery

  This study is testing a new blood test called the Cytophone to see if it can safely find melanoma cells in patients without needing surgery.

  Recruiting Cytoastra · Madison, Wisconsin · NCT06488365

• Monitoring T Cell Responses in Cancer Patients Receiving Anti-PD-1 Therapy

  This study is trying to see how T cells in the blood can help doctors understand how well anti-PD-1 therapy works for people with melanoma, lung cancer, and other cancers.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT06075524

• Testing lower doses of atezolizumab for cancer treatment

  This study is testing whether lower doses of atezolizumab can effectively treat adults with advanced cancer while causing fewer side effects.

  Recruiting Phase 1 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06066138

• Investigating OBX-115 for advanced solid tumors

  This study is testing a new treatment called OBX-115 to see if it can help adults with advanced solid tumors like metastatic melanoma and non-small cell lung cancer feel better and live longer.

  Recruiting at 13 sites Phase 1/2 Obsidian Therapeutics, Inc. · Tucson, Arizona and 13 other locations · NCT06060613

• Combining immunotherapy with prednisone and sirolimus for kidney transplant recipients with advanced skin cancer

  This study is testing a new treatment that combines two immunotherapy drugs with prednisone and sirolimus to see if it helps kidney transplant recipients with advanced skin cancer while keeping their transplanted kidney safe.

  Recruiting at 25 sites Phase 1/2 National Cancer Institute (NCI) · La Jolla, California and 25 other locations · NCT05896839

• Evaluating biomarkers for melanoma immunotherapy response

  This study is testing whether certain gut bacteria and blood markers can help predict how well immunotherapy works for people with advanced melanoma.

  Recruiting Institute of Oncology Ljubljana · Ljubljana · NCT05878977

• Using AI to predict melanoma treatment response based on skin damage

  This study is testing if an AI can help predict how well people with advanced melanoma will respond to a specific treatment by looking at their skin damage from sun exposure.

  Recruiting at 4 sites Nantes University Hospital · Besançon, Bourgogne-Franche-Comté and 19 other locations · NCT05856565

• Combining cryoablation with immunotherapy for advanced melanoma

  This study is testing if freezing tumors along with two immunotherapy drugs can help people with advanced melanoma that hasn't improved with other treatments.

  Recruiting Phase 2 Massachusetts General Hospital · Boston, Massachusetts · NCT05779423

• Combining lifileucel with pembrolizumab for advanced melanoma treatment

  This study is testing if combining a new treatment called lifileucel with pembrolizumab can help people with advanced melanoma feel better compared to just using pembrolizumab alone.

  Recruiting at 71 sites Phase 3 Iovance Biotherapeutics, Inc. · Birmingham, Alabama and 81 other locations · NCT05727904

• Targeted alpha-particle therapy for advanced melanoma

  This study is testing a new treatment for advanced melanoma that uses targeted radiation to see if it can help patients whose cancer can't be surgically removed.

  Recruiting at 15 sites Phase 1/2 Perspective Therapeutics · Orange, California and 15 other locations · NCT05655312

• Using memory-like natural killer cells with nivolumab and relatlimab for advanced melanoma after previous treatments

  This study is testing if a new type of immune cell treatment combined with two existing drugs can help people with advanced melanoma who haven't improved with previous therapies.

  Recruiting Phase 1 Washington University School of Medicine · St Louis, Missouri · NCT05629546

• Evaluating lifileucel in patients with advanced uveal melanoma and certain sarcomas

  This study is testing a new treatment called lifileucel to see if it can help people with advanced uveal melanoma and certain types of sarcomas feel better.

  Recruiting at 2 sites Phase 1 Memorial Sloan Kettering Cancer Center · Harrison, New York and 1 other locations · NCT05607095

• Natural Killer Cell Therapy and Temozolomide for Stage IV Melanoma with Brain Metastasis

  This study is testing a new treatment combining special immune cells and a cancer drug to see if it helps people with advanced melanoma that has spread to the brain.

  Recruiting Phase 1/2 Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT05588453

• Infusion of IOV-4001 for advanced melanoma and lung cancer

  This study is testing a new treatment called IOV-4001 to see if it can help adults with advanced melanoma and lung cancer by targeting and killing their tumor cells.

  Recruiting at 10 sites Phase 1/2 Iovance Biotherapeutics, Inc. · Los Angeles, California and 10 other locations · NCT05361174

• Personalized vaccine combined with pembrolizumab for advanced solid tumors

  This study is testing a new personalized cancer vaccine combined with pembrolizumab to see if it helps people with advanced solid tumors fight their cancer better.

  Recruiting Phase 1/2 Mayo Clinic · Jacksonville, Florida · NCT05269381

• Combining two immunotherapies for advanced melanoma and renal cell carcinoma

  This study is testing if combining two immune therapies can help people with advanced melanoma and kidney cancer whose previous treatments didn't work.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT05155033

• Combining cabozantinib and nivolumab to treat advanced melanoma and head and neck cancer

  This study is testing a combination of two cancer drugs, cabozantinib and nivolumab, to see if they can help people with advanced melanoma or head and neck cancer while also looking at how to better match treatments to patients based on their tumor characteristics.

  Recruiting at 211 sites Phase 2 National Cancer Institute (NCI) · Phoenix, Arizona and 231 other locations · NCT05136196

• Treatment of metastatic melanoma with binimetinib and encorafenib

  This study is testing if a combination of two medications can help people with a specific type of melanoma that has spread to the brain feel better and live longer.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT05026983

• Combining nilotinib with other drugs for treating metastatic melanoma

  This study is testing if adding nilotinib to existing treatments can help people with advanced melanoma that has a specific genetic mutation feel better and tolerate the drugs well.

  Recruiting at 3 sites Phase 1 University of Kentucky · Iowa City, Iowa and 3 other locations · NCT04903119

• Precision radiation for melanoma patients resistant to immune therapy

  This study is testing whether a specific type of radiation therapy can help melanoma patients who aren't responding to their current immune treatment feel better and improve their overall health.

  Recruiting Karolinska University Hospital · Stockholm · NCT04793737

• Avapritinib for treating advanced solid tumors with specific mutations

  This study is testing if a new drug called avapritinib can help people with advanced solid tumors that have specific mutations feel better and live longer after other treatments haven't worked.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT04771520

• Using an influenza vaccine to treat melanoma

  This study is testing whether an influenza vaccine can safely help people with melanoma, a type of skin cancer, by seeing how well it works to shrink tumors and improve their condition.

  Recruiting Phase 1 Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT04697576

• Combining cryoablation and radiation therapy for painful bone metastases

  This study is testing if combining a freezing treatment with radiation can help people with painful bone cancer feel better compared to just using radiation alone.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT04693377

• Comparing two treatment combinations for melanoma with brain metastases

  This study is testing two different treatment combinations for patients with melanoma that has spread to the brain to see which one helps them live longer without the disease getting worse.

  Recruiting at 303 sites Phase 2 SWOG Cancer Research Network · Birmingham, Alabama and 330 other locations · NCT04511013

• Gene modified immune cells for treating advanced melanoma and metastatic solid tumors

  This study is testing if modified immune cells can safely target and attack advanced melanoma and other solid tumors in patients after they receive chemotherapy.

  Recruiting at 3 sites Phase 1 Stanford University · Duarte, California and 2 other locations · NCT04119024

• Using PET-CT scans to predict response to anti-PD-1 therapy in melanoma patients

  This study is testing if PET-CT scans can help predict how well melanoma patients will respond to a specific immunotherapy treatment.

  Recruiting Centre Hospitalier Universitaire de Nice · Nice, CHU de NICE · NCT03888950

NIH-funded research (11)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Harnessing human CD1d-NKT cells to boost melanoma immunotherapy

  A small NIH-funded project tests a new approach that uses a special type of immune cell to help treat metastatic melanoma in patients.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11442673

• New tubulin-blocking agents for metastatic melanoma

  A new class of tiny molecules called fused heterocyclic pyrazines will be studied as potential anti-melanoma drugs, aimed at patients with metastatic melanoma.

  NIH research Middle Tennessee State University · Murfreesboro, United States · NIH-11396429

• CM-HZ01: a new high-boost IL-2 therapy for advanced melanoma

  A new IL-2 based treatment called CM-HZ01 is being developed to help people with metastatic melanoma by steering the immune system toward stronger anti-tumor activity with potentially fewer side effects.

  NIH research Celdara Medical, LLC · Lebanon, United States · NIH-11251635

• New anti-mitotic drugs for metastatic melanoma

  Developing new medicines that stop cancer cells from dividing to help people with metastatic melanoma, including tumors that resist current chemotherapy.

  NIH research Middle Tennessee State University · Murfreesboro, United States · NIH-11142555

• Investigating how dormant melanoma cells can reactivate and promote cancer growth.

  This study is looking at how sleeping melanoma cells can affect nearby cells to help the cancer grow and resist treatment, and it's designed for researchers like Dr. Fane to learn new ways to find better treatments for melanoma.

  NIH research Research Inst of Fox Chase Can Ctr · Philadelphia, United States · NIH-11074120

• Developing a new treatment for metastatic melanoma using a specialized form of interleukin-2.

  This study is testing a new treatment called CM-HZ01 that helps boost your immune system to fight metastatic melanoma by specifically activating certain immune cells, aiming to make the existing IL-2 therapy work better with fewer side effects for patients who don’t have many options left.

  NIH research Celdara Medical, LLC · Lebanon, United States · NIH-11069291

• Improving detection of early-stage metastatic melanoma using advanced microscopy

  This study is testing a new imaging technique to help doctors better identify early-stage melanomas that have spread, so patients can get the right treatment sooner and improve their chances of recovery.

  NIH research Duke University · Durham, United States · NIH-11011335

• Developing new drugs to treat advanced melanoma

  This study is working on developing new treatments for metastatic melanoma, a tough type of skin cancer, by creating special compounds that can stop cancer cells from dividing, which could lead to better and safer options for patients.

  NIH research Middle Tennessee State University · Murfreesboro, United States · NIH-10937173

• Combining a new drug with immunotherapy to treat advanced melanoma

  This study is exploring a new way to boost cancer treatment for people with advanced melanoma by using a special molecule called CBL0137 alongside two common immunotherapy drugs, nivolumab and ipilimumab, to help your immune system fight the cancer better.

  NIH research Research Inst of Fox Chase Can Ctr · Philadelphia, United States · NIH-10867390

• Investigating UCHL5's role in melanoma spread

  This study is looking at how a protein called UCHL5 affects the spread of melanoma, a type of skin cancer, to help find new ways to treat it.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-10866382

• Monitoring treatment response in patients with advanced melanoma

  This study is looking at a new blood test that can help people with metastatic melanoma see how well their treatments are working, making it easier and less invasive to track their progress without needing painful biopsies.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-10221639

Related topics

Quick answers

How many Metastatic Melanoma clinical trials are recruiting right now?

38, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 17 countries. The most sites are in United States (29 trials), Australia (5 trials), France (3 trials), Slovenia (3 trials), Germany (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 8, Phase 1/2: 8, Phase 2: 8, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →