Condition

Unresectable Melanoma clinical trials and research

• 11Clinical trials
• 17Countries

Newest Unresectable Melanoma clinical trials

All recruiting trials (11)

• Dual-target CSPG4/GD2 CAR-NK Cells for Advanced Melanoma

  This study tests a donor-derived CAR-NK cell therapy that targets CSPG4 or GD2 in adults with unresectable or metastatic melanoma after standard treatments.

  Recruiting Phase 1/2 Beijing Biotech · Shenzhen, Guangdong · NCT07627698

• Investigating IOV-3001 for Advanced Melanoma Treatment

  This study is testing a new treatment called IOV-3001 to see if it can help adults with advanced melanoma who haven't been able to have surgery.

  Recruiting at 5 sites Phase 1/2 Iovance Biotherapeutics, Inc. · Denver, Colorado and 4 other locations · NCT06940739

• LNS8801 alone or with pembrolizumab for people whose melanoma has stopped responding.

  This trial will test whether LNS8801, by itself or combined with pembrolizumab, can keep melanoma that progressed after anti‑PD‑1 therapy from growing.

  Recruiting at 9 sites Phase 2/3 Linnaeus Therapeutics, Inc. · Newport Beach, California and 8 other locations · NCT06624644

• Dietary intervention to improve immune therapy response in melanoma patients

  This study is testing whether a special diet can help improve the response to immune therapy in patients with advanced melanoma.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT06466434

• Analyzing PET scans and blood samples in melanoma patients receiving immunotherapy

  This study is testing if early PET scans and blood tests can help predict how well immunotherapy works for people with advanced melanoma.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT06199713

• Combining immunotherapy with prednisone and sirolimus for kidney transplant recipients with advanced skin cancer

  This study is testing a new treatment that combines two immunotherapy drugs with prednisone and sirolimus to see if it helps kidney transplant recipients with advanced skin cancer while keeping their transplanted kidney safe.

  Recruiting at 25 sites Phase 1/2 National Cancer Institute (NCI) · La Jolla, California and 25 other locations · NCT05896839

• Combining lifileucel with pembrolizumab for advanced melanoma treatment

  This study is testing if combining a new treatment called lifileucel with pembrolizumab can help people with advanced melanoma feel better compared to just using pembrolizumab alone.

  Recruiting at 71 sites Phase 3 Iovance Biotherapeutics, Inc. · Birmingham, Alabama and 81 other locations · NCT05727904

• Combining Sarilumab with Other Treatments for Advanced Melanoma

  This study is testing a new combination of treatments for people with advanced melanoma to see if it helps them feel better and live longer.

  Recruiting at 4 sites Phase 2 NYU Langone Health · Los Angeles, California and 3 other locations · NCT05428007

• Infusion of IOV-4001 for advanced melanoma and lung cancer

  This study is testing a new treatment called IOV-4001 to see if it can help adults with advanced melanoma and lung cancer by targeting and killing their tumor cells.

  Recruiting at 10 sites Phase 1/2 Iovance Biotherapeutics, Inc. · Los Angeles, California and 10 other locations · NCT05361174

• Personalized vaccine combined with pembrolizumab for advanced solid tumors

  This study is testing a new personalized cancer vaccine combined with pembrolizumab to see if it helps people with advanced solid tumors fight their cancer better.

  Recruiting Phase 1/2 Mayo Clinic · Jacksonville, Florida · NCT05269381

• Combining cabozantinib and nivolumab to treat advanced melanoma and head and neck cancer

  This study is testing a combination of two cancer drugs, cabozantinib and nivolumab, to see if they can help people with advanced melanoma or head and neck cancer while also looking at how to better match treatments to patients based on their tumor characteristics.

  Recruiting at 211 sites Phase 2 National Cancer Institute (NCI) · Phoenix, Arizona and 231 other locations · NCT05136196

Related topics

Quick answers

How many Unresectable Melanoma clinical trials are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 17 countries. The most sites are in United States (10 trials), Australia (2 trials), China (1 trial), Belgium (1 trial), Canada (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 5, Phase 2: 2, Phase 2/3: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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