Condition
Locally Advanced Melanoma clinical trials and research
Research outlook What's coming for Melanoma: the next 6 months to 5 yearsAs of November 12, 2026, Find a Trial lists 6 Locally Advanced Melanoma clinical trials that are recruiting, at sites in 2 countries (most in United States (5), Italy (1)). By phase: Phase 1/2 (1), Phase 1 (1), Phase 2 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 6Clinical trials
- 2Countries
Newest Locally Advanced Melanoma clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Comparing two immunotherapy combinations and their immune effects in unresectable or metastatic melanoma | — | Pittsburgh, Pennsylvania | Recruiting | Oct 31, 2025 |
| Evaluating Oral Impact® with Anti PD-1 Treatment for Advanced Melanoma | — | Naples | Recruiting | Mar 17, 2025 |
| Monitoring T Cell Responses in Cancer Patients Receiving Anti-PD-1 Therapy | — | Rochester, Minnesota | Recruiting | Oct 10, 2023 |
| Testing lower doses of atezolizumab for cancer treatment | Phase 1 | Bethesda, Maryland | Recruiting | Oct 4, 2023 |
| Personalized vaccine combined with pembrolizumab for advanced solid tumors | Phase 1/2 | Jacksonville, Florida | Recruiting | Mar 8, 2022 |
| Avapritinib for treating advanced solid tumors with specific mutations | Phase 2 | Houston, Texas | Recruiting | Feb 25, 2021 |
All recruiting trials (6)
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Comparing two immunotherapy combinations and their immune effects in unresectable or metastatic melanoma
This will test whether two different first-line immunotherapy combinations produce different immune responses in tumors and blood of people with unresectable or metastatic melanoma.
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Evaluating Oral Impact® with Anti PD-1 Treatment for Advanced Melanoma
This study is testing if Oral Impact® can help people with advanced melanoma have fewer side effects when they start treatment with an immune therapy called nivolumab.
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Monitoring T Cell Responses in Cancer Patients Receiving Anti-PD-1 Therapy
This study is trying to see how T cells in the blood can help doctors understand how well anti-PD-1 therapy works for people with melanoma, lung cancer, and other cancers.
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Testing lower doses of atezolizumab for cancer treatment
This study is testing whether lower doses of atezolizumab can effectively treat adults with advanced cancer while causing fewer side effects.
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Personalized vaccine combined with pembrolizumab for advanced solid tumors
This study is testing a new personalized cancer vaccine combined with pembrolizumab to see if it helps people with advanced solid tumors fight their cancer better.
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Avapritinib for treating advanced solid tumors with specific mutations
This study is testing if a new drug called avapritinib can help people with advanced solid tumors that have specific mutations feel better and live longer after other treatments haven't worked.
Related topics
Quick answers
How many Locally Advanced Melanoma clinical trials are recruiting right now?
6, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 2 countries. The most sites are in United States (5 trials), Italy (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 1/2: 1, Phase 1: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.