Condition

Stage IV Lung Cancer AJCC v8 clinical trials and research

• 45Clinical trials
• 1Country

Newest Stage IV Lung Cancer AJCC v8 clinical trials

All recruiting trials (45)

• Understand cancer cachexia subtypes in advanced cancers

  This study tests how cancer cachexia presents in people with advanced colorectal, pancreatic, or lung cancer to see if different subtypes relate to outcomes.

  Recruiting Kaiser Permanente · Pleasanton, California · NCT07776353

• 64Cu-DOTA-Pembrolizumab PET to See If Treatment Is Working in Stage IV NSCLC

  This study tests a new PET imaging agent paired with pembrolizumab to see if it can show which tumors are still responding in adults with stage IV NSCLC who are already receiving pembrolizumab.

  Recruiting Phase 1 City of Hope Medical Center · Duarte, California · NCT07619599

• Morning versus afternoon immunotherapy for advanced or metastatic solid tumors

  This trial tests whether giving standard immune checkpoint inhibitor therapy in the morning versus the afternoon changes outcomes for adults with advanced or metastatic solid tumors.

  Recruiting Phase 4 OHSU Knight Cancer Institute · Portland, Oregon · NCT07405086

• Advanced NSCLC with actionable mutations after targeted therapy and chemo: expanded Lung-MAP treatment

  This phase II trial tests whether sacituzumab govitecan alone, ivonescimab alone, or the combination of both can help people with advanced or recurrent NSCLC that has a targetable genetic change.

  Recruiting at 41 sites Phase 2 SWOG Cancer Research Network · Berkeley, California and 40 other locations · NCT07393555

• SX-682 with Atezolizumab for advanced or metastatic NSCLC

  This phase 2 trial tests whether combining SX-682 with atezolizumab can help people with advanced, metastatic, or recurrent NSCLC who have progressed after prior treatments.

  Recruiting Phase 2 University of Washington · Seattle, Washington · NCT07322341

• Using blood and tissue biomarkers to guide immunotherapy and later treatment choices in advanced non-small cell lung cancer

  This trial tests whether blood and tumor biomarkers can predict who will respond to first-line PD‑1/PD‑L1 immunotherapy and help pick better second-line treatments for people with stage IIIB–IV non‑small cell lung cancer.

  Recruiting at 13 sites Phase 2 City of Hope Medical Center · Goodyear, Arizona and 12 other locations · NCT07288034

• GT103 plus pembrolizumab for advanced STK11‑mutant non‑small cell lung cancer

  This trial tests whether adding GT103 to pembrolizumab can help adults with advanced or metastatic STK11‑mutant non‑small cell lung cancer.

  Recruiting Phase 2 Roswell Park Cancer Institute · Buffalo, New York · NCT07017829

• Combining sotorasib and trastuzumab deruxtecan for advanced KRAS G12C non-small cell lung cancer

  This trial tests whether giving sotorasib with trastuzumab deruxtecan is safe and can shrink tumors or slow progression in people with locally advanced or metastatic non-small cell lung cancer that has a KRAS G12C mutation and progressed after prior targeted therapy, immunotherapy, and chemotherapy.

  Recruiting at 9 sites Phase 1/2 National Cancer Institute (NCI) · Sacramento, California and 8 other locations · NCT07012031

• Photon VMAT craniospinal radiation for leptomeningeal disease from breast or non‑small cell lung cancer

  This trial tests whether craniospinal irradiation delivered with photon VMAT can help adults whose breast cancer or non‑small cell lung cancer has spread to the meninges (leptomeningeal disease).

  Recruiting at 2 sites Phase 2 City of Hope Medical Center · Duarte, California and 1 other locations · NCT06910761

• New tool to help lung cancer patients understand their illness better

  This study tests a new tool to help lung cancer patients better understand their illness and treatment options compared to regular care.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT06743308

• Adding diclofenac to single-agent immunotherapy for metastatic non-small cell lung cancer

  This trial tests if adding the NSAID diclofenac to single‑agent PD‑1/PD‑L1 immunotherapy can help people with metastatic non‑small cell lung cancer who are showing early signs of progression.

  Recruiting at 2 sites Phase 2 Emory University · Atlanta, Georgia and 1 other locations · NCT06731270

• Combining cemiplimab with standard treatment for advanced lung cancer

  This study is testing if adding the immunotherapy drug cemiplimab to standard treatments can help people with advanced lung cancer live longer and feel better compared to just the standard treatments alone.

  Recruiting at 399 sites Phase 2/3 SWOG Cancer Research Network · Daphne, Alabama and 412 other locations · NCT06616584

• Hippocampal avoidance during craniospinal irradiation for breast and lung cancer with leptomeningeal metastases

  This study is testing a new way of giving radiation therapy to help people with breast or lung cancer that has spread to their brain, aiming to reduce symptoms while protecting their memory.

  Recruiting at 2 sites Phase 2 University of Washington · San Francisco, California and 2 other locations · NCT06518057

• Comparing proton radiation therapy to standard radiation for leptomeningeal metastasis

  This study is testing whether proton radiation therapy is better than standard radiation for people with leptomeningeal metastasis from breast or lung cancer to see if it helps them live longer and stay healthier.

  Recruiting at 58 sites Phase 3 NRG Oncology · Phoenix, Arizona and 57 other locations · NCT06500481

• Combination treatment for advanced lung cancer with specific mutations

  This study is testing a new combination of medications for people with advanced lung cancer that has specific mutations and hasn't improved with other treatments, to see if it helps them live longer without the cancer getting worse.

  Recruiting at 2 sites Phase 2 Emory University · Atlanta, Georgia and 2 other locations · NCT06495125

• Evaluating insomnia in patients with metastatic lung cancer

  This study looks at how common sleep problems are in people with advanced lung cancer to better understand their struggles with insomnia.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT06472804

• Combining iadademstat with immunotherapy for advanced small cell lung cancer

  This study is testing whether adding a new drug called iadademstat to standard immunotherapy can help people with advanced small cell lung cancer live longer without their disease getting worse.

  Recruiting at 33 sites Phase 1/2 National Cancer Institute (NCI) · Duarte, California and 42 other locations · NCT06287775

• Combining carfilzomib and sotorasib for treating advanced lung cancer with KRAS G12C mutation

  This study is testing a new combination of two drugs, carfilzomib and sotorasib, to see if it can safely help people with advanced lung cancer that has a specific KRAS G12C mutation after they have tried other treatments.

  Recruiting at 2 sites Phase 1 City of Hope Medical Center · Duarte, California and 1 other locations · NCT06249282

• Using gilteritinib to treat advanced ALK positive lung cancer

  This study is testing if gilteritinib can safely help people with advanced ALK positive lung cancer who haven't had success with other treatments.

  Recruiting Phase 1 University of Michigan Rogel Cancer Center · Los Angeles, California and 2 other locations · NCT06225427

• Improving decision-making for lung cancer treatment

  This study is testing a new communication tool to see if it helps patients with non-small cell lung cancer feel more satisfied and confident in their treatment choices when talking with their doctors.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT06122064

• Combining chemotherapy with immunotherapy for older adults with advanced lung cancer

  This study is testing if adding chemotherapy to immunotherapy can help older adults with advanced lung cancer live longer and feel better compared to just using immunotherapy alone.

  Recruiting at 271 sites Phase 3 National Cancer Institute (NCI) · Fayetteville, Arkansas and 329 other locations · NCT06096844

• Monitoring T Cell Responses in Cancer Patients Receiving Anti-PD-1 Therapy

  This study is trying to see how T cells in the blood can help doctors understand how well anti-PD-1 therapy works for people with melanoma, lung cancer, and other cancers.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT06075524

• Observational study on cancer cachexia subtypes

  This study is trying to identify different types of weight and muscle loss in patients with advanced colorectal, lung, or pancreatic cancers to help improve future treatments.

  Recruiting at 196 sites University of Rochester · Fort Smith, Arkansas and 224 other locations · NCT06073431

• Targeted treatment for advanced lung cancer with a specific gene change

  This study is testing if a new lung cancer treatment called tepotinib, with or without another drug called ramucirumab, can help people with advanced non-small cell lung cancer that has a specific gene change.

  Recruiting at 246 sites Phase 2 SWOG Cancer Research Network · Daphne, Alabama and 277 other locations · NCT06031688

• Combining advanced radiation therapy with a targeted drug for specific lung cancer patients

  This study is testing whether combining advanced radiation therapy with the drug osimertinib can help people with specific types of lung cancer control their disease better and improve their quality of life.

  Recruiting Phase 2 City of Hope Medical Center · Duarte, California and 1 other locations · NCT06014827

• Using electric fields to treat spinal cancer spread in breast cancer patients

  This study tests if wearing a portable device that uses electric fields can help breast cancer patients whose cancer has spread to the spine feel better and slow down tumor growth.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT05746325

• CPI-613 combined with hydroxychloroquine and chemotherapy for advanced solid tumors

  This study is testing a new combination of treatments, including CPI-613 and hydroxychloroquine, to see if it can help people with advanced solid tumors that haven't improved with other chemotherapy.

  Recruiting Phase 2 Northwestern University · Chicago, Illinois · NCT05733000

• Comparing targeted drug combinations for advanced lung cancer with specific gene changes

  This study is testing different combinations of targeted drugs to see if they can help people with advanced lung cancer that has specific gene changes live longer and feel better.

  Recruiting at 372 sites Phase 2 SWOG Cancer Research Network · Daphne, Alabama and 453 other locations · NCT05642572

• Combining SX-682 and Pembrolizumab for Advanced Lung Cancer Treatment

  This study is testing if a new oral medication called SX-682, when combined with the IV drug pembrolizumab, can help people with advanced lung cancer feel better and improve their treatment outcomes.

  Recruiting Phase 2 University of Washington · Seattle, Washington · NCT05570825

• Combining adaptive radiation therapy with immunotherapy for advanced lung cancer treatment

  This study is testing a new way of giving radiation therapy along with immunotherapy to see if it helps people with advanced lung cancer feel better and live longer.

  Recruiting Phase 1/2 Vanderbilt-Ingram Cancer Center · Nashville, Tennessee · NCT05501665

• Combining low-dose interleukin-2 and pembrolizumab for advanced lung cancer treatment

  This study is testing a new combination of low-dose interleukin-2 and pembrolizumab to see if it can help people with untreated stage IV non-small cell lung cancer fight their disease better.

  Recruiting Early Phase 1 Emory University · Atlanta, Georgia · NCT05493566

• Personalized vaccine combined with pembrolizumab for advanced solid tumors

  This study is testing a new personalized cancer vaccine combined with pembrolizumab to see if it helps people with advanced solid tumors fight their cancer better.

  Recruiting Phase 1/2 Mayo Clinic · Jacksonville, Florida · NCT05269381

• Combining palliative radiotherapy with lurbinectedin for extensive stage small cell lung cancer

  This study is testing if combining palliative radiotherapy with the drug lurbinectedin can help people with advanced small cell lung cancer feel better after their chemotherapy has stopped working.

  Recruiting Phase 1 Emory University · Atlanta, Georgia and 2 other locations · NCT05244239

• A vaccine to treat advanced lung cancer

  This study is testing a new vaccine for advanced lung cancer to see if it can help shrink tumors when combined with a special immune booster.

  Recruiting Phase 2 University of Washington · Omaha, Nebraska and 1 other locations · NCT05242965

• Combining PBF-1129 and Nivolumab for Advanced Lung Cancer Treatment

  This study is testing a new combination of two drugs, PBF-1129 and nivolumab, to see if it can help people with advanced lung cancer live longer and feel better.

  Recruiting Phase 1 Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT05234307

• Personalized vaccine treatment for advanced melanoma, breast cancer, and lung cancer

  This study is testing a personalized vaccine combined with a treatment called nivolumab to see if it can help people with advanced melanoma, breast cancer, or lung cancer fight their tumors better.

  Recruiting Phase 1 Fred Hutchinson Cancer Center · Seattle, Washington · NCT05098210

• Using temozolomide and atezolizumab for advanced small cell lung cancer

  This study is testing if a combination of two drugs, temozolomide and atezolizumab, can help people with advanced small cell lung cancer live longer and feel better.

  Recruiting at 5 sites Phase 2 Big Ten Cancer Research Consortium · Chicago, Illinois and 4 other locations · NCT04919382

• Combining osimertinib and tegavivint for treating metastatic EGFR-mutant lung cancer

  This study is testing a new combination of two drugs, osimertinib and tegavivint, to see if it can help people with advanced lung cancer caused by EGFR mutations feel better and live longer.

  Recruiting Phase 1 Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT04780568

• Avapritinib for treating advanced solid tumors with specific mutations

  This study is testing if a new drug called avapritinib can help people with advanced solid tumors that have specific mutations feel better and live longer after other treatments haven't worked.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT04771520

• Combining MRX-2843 and Osimertinib for Advanced Lung Cancer Treatment

  This study is testing whether combining two medications, MRX-2843 and osimertinib, can safely help people with advanced lung cancer caused by EGFR mutations.

  Recruiting Phase 1 Emory University · Atlanta, Georgia · NCT04762199

• Combining osimertinib and bevacizumab for treating advanced EGFR-mutant lung cancer

  This study is testing if adding bevacizumab to osimertinib can help people with advanced EGFR-mutant lung cancer live longer and feel better compared to taking osimertinib alone.

  Recruiting at 328 sites Phase 3 National Cancer Institute (NCI) · Anchorage, Alaska and 603 other locations · NCT04181060

• Investigating PET/CT changes during treatment for advanced lung cancer

  This study is testing how PET and CT scans change during treatment for advanced lung cancer to see if they can help predict how well the treatment is working.

  Recruiting University of Washington · Seattle, Washington · NCT04151940

• Yoga intervention to improve physical performance and quality of life for cancer patients and their caregivers

  This study tests whether a yoga program can help improve physical performance and quality of life for cancer patients and their caregivers during radiotherapy.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT03948100

• Exploring gut microbiome and fecal transplant effects on GI issues in cancer patients

  This study is testing how the gut bacteria affect stomach issues in cancer patients receiving certain treatments and whether a stool transplant can help relieve those problems.

  Recruiting Phase 1 M.D. Anderson Cancer Center · Houston, Texas · NCT03819296

• Using a special dye to detect lung cancer during surgery

  This study is testing a special dye to see if it can help doctors find lung cancer more easily during surgery.

  Recruiting Phase 1/2 Stanford University · Palo Alto, California · NCT03582124

Related topics

Quick answers

How many Stage IV Lung Cancer AJCC v8 clinical trials are recruiting right now?

45, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

All of them have sites in United States. Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 16, Phase 1: 9, Phase 1/2: 5, Phase 3: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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