Condition

Metastatic Renal Cell Carcinoma clinical trials and research

• 22Clinical trials
• 4NIH research projects
• 13Countries

Newest Metastatic Renal Cell Carcinoma clinical trials

All recruiting trials (22)

• Morning versus afternoon immunotherapy for advanced or metastatic solid tumors

  This trial tests whether giving standard immune checkpoint inhibitor therapy in the morning versus the afternoon changes outcomes for adults with advanced or metastatic solid tumors.

  Recruiting Phase 4 OHSU Knight Cancer Institute · Portland, Oregon · NCT07405086

• PF-08634404 alone and with other anticancer medicines for adults with advanced kidney cancer.

  This tests whether PF-08634404, given alone or with other cancer medicines, is safe and helps adults with locally advanced or metastatic kidney cancer who have not had prior systemic treatment.

  Recruiting at 157 sites Phase 1/2 Pfizer · Phoenix, Arizona and 182 other locations · NCT07227415

• Combining sasanlimab, palbociclib, and axitinib for metastatic kidney cancer

  This test tries a combination of sasanlimab, palbociclib, and axitinib in people with advanced or metastatic clear cell or translocation renal cell carcinoma to see if it works and is safe.

  Recruiting at 2 sites Phase 2 Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT07123090

• Zanzalintinib with a bone-strengthening agent for metastatic clear cell RCC with bone metastases

  This phase 2 trial tests zanzalintinib plus a bone-strengthening agent in adults with metastatic clear cell renal cell cancer that has spread to bone and progressed after 1–3 prior therapies, including IO therapy.

  Recruiting Phase 2 University of California, San Francisco · San Francisco, California · NCT07043608

• Digital symptom monitoring for people starting cabozantinib plus nivolumab for advanced clear-cell kidney cancer

  This project tests whether weekly digital self-reports of symptoms can help guide treatment management for adults beginning cabozantinib plus nivolumab for advanced clear-cell kidney cancer during the first three months.

  Recruiting at 3 sites Phase 4 Centre Francois Baclesse · Annecy and 18 other locations · NCT07028125

• Combination of XL092 and Immunotherapy for Advanced Clear Cell Kidney Cancer

  This study is testing if a new drug called XL092, alone or with another treatment called nivolumab, can help people with advanced clear cell kidney cancer who haven't responded well to previous therapies.

  Recruiting at 5 sites Phase 2 Hoosier Cancer Research Network · La Jolla, California and 4 other locations · NCT06863311

• Combining abemaciclib and cabozantinib for treating metastatic clear cell renal cell carcinoma

  This study is testing a combination of two drugs, abemaciclib and cabozantinib, to see if they can safely help people with advanced clear cell kidney cancer.

  Recruiting at 8 sites Phase 1/2 Memorial Sloan Kettering Cancer Center · Baltimore, Maryland and 7 other locations · NCT06835972

• Combining axitinib with nivolumab for advanced kidney cancer treatment

  This study is testing if adding a drug called axitinib to nivolumab can help people with advanced kidney cancer see better results than just using nivolumab alone.

  Recruiting Phase 2 Consorzio Oncotech · Brescia and 22 other locations · NCT05817903

• Impact of Exercise and Statins on Cancer Treatment

  This study is testing if doing supervised exercise while taking cancer drugs helps people with metastatic breast, kidney, ovarian, and prostate cancer feel better and respond better to their treatment compared to exercising on their own, and if adding a cholesterol-lowering medication can make it even more effective.

  Recruiting Phase 3 Tampere University Hospital · Tampere, Länsi-Suomi · NCT05796973

• Evaluating OATD-02 for advanced solid tumors

  This study is testing a new oral medication called OATD-02 to see if it can help people with advanced solid tumors, like colorectal and ovarian cancer, by making their tumors respond better to treatment.

  Recruiting at 3 sites Phase 1 Molecure S.A. · Bydgoszcz, Kuyavian-Pomeranian Voivodeship and 2 other locations · NCT05759923

• Testing a microdevice for drug delivery in kidney cancer

  This study is testing a tiny device that delivers small amounts of cancer drugs directly to kidney tumors to see if it helps people with advanced kidney cancer.

  Recruiting Phase 1 Brigham and Women's Hospital · Boston, Massachusetts · NCT05700461

• Combining Stereotactic Radiation with Immune Therapy for Advanced Kidney Cancer

  This study is testing whether adding a special type of radiation therapy to standard immune treatment can help people with advanced kidney cancer live longer and feel better.

  Recruiting at 303 sites Phase 2 NRG Oncology · Birmingham, Alabama and 347 other locations · NCT05327686

• Personalized vaccine combined with pembrolizumab for advanced solid tumors

  This study is testing a new personalized cancer vaccine combined with pembrolizumab to see if it helps people with advanced solid tumors fight their cancer better.

  Recruiting Phase 1/2 Mayo Clinic · Jacksonville, Florida · NCT05269381

• Alternative dosing schedule for cabozantinib in advanced kidney and neuroendocrine tumors

  This study is testing a new way to give cabozantinib to see if it helps people with advanced kidney cancer and neuroendocrine tumors feel better and stay safe while being treated.

  Recruiting Phase 2 Fox Chase Cancer Center · Philadelphia, Pennsylvania · NCT05263050

• Combining two immunotherapies for advanced melanoma and renal cell carcinoma

  This study is testing if combining two immune therapies can help people with advanced melanoma and kidney cancer whose previous treatments didn't work.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT05155033

• Combining Tumor Treating Fields with Cabozantinib or Pembrolizumab and Nab-Paclitaxel for Advanced Solid Tumors

  This study is testing a new treatment that combines tumor treating fields with two different cancer drugs to see if it helps people with advanced solid tumors in the abdomen or chest.

  Recruiting Phase 1 M.D. Anderson Cancer Center · Houston, Texas · NCT05092373

• Using targeted radiation therapy for patients with limited progression of kidney cancer on immune therapy

  This study is testing if a special type of radiation therapy can help people with kidney cancer who are seeing limited growth while on immune therapy feel better and live longer.

  Recruiting Phase 2 Yale University · New Haven, Connecticut · NCT04974671

• Identifying urine markers to predict responses to immunotherapy in kidney cancer patients

  This study is trying to find out if certain substances in urine can help predict how well immunotherapy will work for people with advanced kidney cancer.

  Recruiting National Taiwan University Hospital · Taipei · NCT04712305

• Combining cryoablation and radiation therapy for painful bone metastases

  This study is testing if combining a freezing treatment with radiation can help people with painful bone cancer feel better compared to just using radiation alone.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT04693377

• Comparing immunotherapy with and without kidney surgery for metastatic kidney cancer

  This study is testing whether adding kidney surgery to a standard immunotherapy treatment can help people with advanced kidney cancer live longer and feel better.

  Recruiting at 340 sites Phase 3 SWOG Cancer Research Network · Birmingham, Alabama and 386 other locations · NCT04510597

• Using targeted radiotherapy for specific metastatic kidney cancer cases

  This study is testing whether targeted radiotherapy can help people with advanced kidney cancer who have a few areas of growth while keeping the rest of their cancer under control.

  Recruiting at 8 sites Phase 2 Centre Francois Baclesse · Albi and 29 other locations · NCT04299646

• Olaparib treatment for patients with metastatic kidney cancer and specific gene mutations

  This study is testing if the oral medication olaparib can help people with advanced kidney cancer who have certain gene mutations and have already tried other treatments.

  Recruiting Phase 2 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT03786796

NIH-funded research (4)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding how kidney cancer spreads to bone and how to fight it

  A patient-focused look at how clear cell renal cell carcinoma spreads to bone and how new treatments might help people with advanced disease.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11446651

• Biomarkers to predict and understand response to anti-PD-1 therapy in metastatic kidney cancer

  This grant tests tissue clues like immune cells and tumor targets to figure out why some patients with metastatic kidney cancer respond to anti-PD-1 therapy while others do not.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11346038

• Finding clues in tissue to improve kidney cancer treatment

  This project looks for clues in tumor tissue to understand why some patients with advanced kidney cancer respond to immunotherapy and others do not.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11094731

• Identifying biomarkers for effective immunotherapy in kidney cancer

  This study is looking at how certain markers in tissue samples can help doctors figure out which patients with advanced kidney cancer are most likely to respond well to a specific immunotherapy treatment, so they can tailor the best care for each person.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-10847506

Related topics

Quick answers

How many Metastatic Renal Cell Carcinoma clinical trials are recruiting right now?

22, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in United States (16 trials), Australia (2 trials), France (2 trials), Poland (1 trial), Canada (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 10, Phase 1: 3, Phase 1/2: 3, Phase 4: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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