Condition

Locally Advanced Malignant Solid Neoplasm clinical trials and research

• 8Clinical trials
• 2Countries

Newest Locally Advanced Malignant Solid Neoplasm clinical trials

All recruiting trials (8)

• Combining two anticancer drugs for treating advanced gastric and gastroesophageal junction cancers

  This study is testing a new combination of two cancer drugs to see if they can help people with advanced HER2-positive gastric or gastroesophageal junction cancers feel better and live longer.

  Recruiting Phase 1 National Cancer Institute (NCI) · Houston, Texas · NCT06364410

• Monitoring T Cell Responses in Cancer Patients Receiving Anti-PD-1 Therapy

  This study is trying to see how T cells in the blood can help doctors understand how well anti-PD-1 therapy works for people with melanoma, lung cancer, and other cancers.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT06075524

• Targeted therapy for advanced solid tumors based on genetic testing

  This study is testing whether matching patients with advanced solid tumors to specific treatments based on their genetic makeup can improve their outcomes when standard options have failed.

  Recruiting at 437 sites Phase 2 National Cancer Institute (NCI) · Birmingham, Alabama and 483 other locations · NCT05564377

• Personalized vaccine combined with pembrolizumab for advanced solid tumors

  This study is testing a new personalized cancer vaccine combined with pembrolizumab to see if it helps people with advanced solid tumors fight their cancer better.

  Recruiting Phase 1/2 Mayo Clinic · Jacksonville, Florida · NCT05269381

• Treatment of advanced solid tumors with larotrectinib for NTRK gene amplification

  This study is testing if a new drug called larotrectinib can help people with advanced solid tumors that have a specific gene change called NTRK amplification.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT04879121

• Avapritinib for treating advanced solid tumors with specific mutations

  This study is testing if a new drug called avapritinib can help people with advanced solid tumors that have specific mutations feel better and live longer after other treatments haven't worked.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT04771520

• Mobile app to help cancer patients with advance care planning

  This study tests whether a mobile app can help cancer patients talk about and plan their future care wishes with their families and doctors better than standard care alone.

  Recruiting Fred Hutchinson Cancer Center · Manhasset, New York and 3 other locations · NCT04515810

• Combining durvalumab with chemotherapy for advanced solid tumors

  This study is testing if combining an immunotherapy drug called durvalumab with standard chemotherapy can help people with advanced solid tumors by improving their immune response and slowing down tumor growth.

  Recruiting Phase 2 National Cancer Institute (NCI) · Bethesda, Maryland · NCT03907475

Related topics

Quick answers

How many Locally Advanced Malignant Solid Neoplasm clinical trials are recruiting right now?

8, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in United States (8 trials), Puerto Rico (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 1: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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