Condition

Clinical Stage IV Cutaneous Melanoma AJCC v8 clinical trials and research

• 13Clinical trials
• 1Country

Newest Clinical Stage IV Cutaneous Melanoma AJCC v8 clinical trials

All recruiting trials (13)

• Time-of-day immunotherapy for advanced melanoma

  This trial tests whether giving the immune drugs ipilimumab and nivolumab in the morning rather than later in the day helps people with unresectable or metastatic melanoma respond better.

  Recruiting Phase 2 Emory University · Atlanta, Georgia and 1 other locations · NCT07155317

• Comparing home and clinic administration of nivolumab for cancer treatment

  This study tests whether giving cancer patients their treatment at home instead of in a clinic makes them feel better and prefer their care more.

  Recruiting Phase 2 Mayo Clinic · Jacksonville, Florida · NCT06265285

• Monitoring T Cell Responses in Cancer Patients Receiving Anti-PD-1 Therapy

  This study is trying to see how T cells in the blood can help doctors understand how well anti-PD-1 therapy works for people with melanoma, lung cancer, and other cancers.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT06075524

• Combining immunotherapy with prednisone and sirolimus for kidney transplant recipients with advanced skin cancer

  This study is testing a new treatment that combines two immunotherapy drugs with prednisone and sirolimus to see if it helps kidney transplant recipients with advanced skin cancer while keeping their transplanted kidney safe.

  Recruiting at 25 sites Phase 1/2 National Cancer Institute (NCI) · La Jolla, California and 25 other locations · NCT05896839

• Natural Killer Cell Therapy and Temozolomide for Stage IV Melanoma with Brain Metastasis

  This study is testing a new treatment combining special immune cells and a cancer drug to see if it helps people with advanced melanoma that has spread to the brain.

  Recruiting Phase 1/2 Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT05588453

• Personalized vaccine combined with pembrolizumab for advanced solid tumors

  This study is testing a new personalized cancer vaccine combined with pembrolizumab to see if it helps people with advanced solid tumors fight their cancer better.

  Recruiting Phase 1/2 Mayo Clinic · Jacksonville, Florida · NCT05269381

• Combining cabozantinib and nivolumab to treat advanced melanoma and head and neck cancer

  This study is testing a combination of two cancer drugs, cabozantinib and nivolumab, to see if they can help people with advanced melanoma or head and neck cancer while also looking at how to better match treatments to patients based on their tumor characteristics.

  Recruiting at 211 sites Phase 2 National Cancer Institute (NCI) · Phoenix, Arizona and 231 other locations · NCT05136196

• Personalized vaccine treatment for advanced melanoma, breast cancer, and lung cancer

  This study is testing a personalized vaccine combined with a treatment called nivolumab to see if it can help people with advanced melanoma, breast cancer, or lung cancer fight their tumors better.

  Recruiting Phase 1 Fred Hutchinson Cancer Center · Seattle, Washington · NCT05098210

• Treatment of advanced solid tumors with IACS-6274 and other medications

  This study is testing a new drug called IACS-6274, alone and with other medications, to see how well it can help people with advanced solid tumors and what the safest dose is.

  Recruiting Phase 1 M.D. Anderson Cancer Center · Houston, Texas · NCT05039801

• Treatment of metastatic melanoma with binimetinib and encorafenib

  This study is testing if a combination of two medications can help people with a specific type of melanoma that has spread to the brain feel better and live longer.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT05026983

• Using an influenza vaccine to treat melanoma

  This study is testing whether an influenza vaccine can safely help people with melanoma, a type of skin cancer, by seeing how well it works to shrink tumors and improve their condition.

  Recruiting Phase 1 Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT04697576

• Comparing two treatment combinations for melanoma with brain metastases

  This study is testing two different treatment combinations for patients with melanoma that has spread to the brain to see which one helps them live longer without the disease getting worse.

  Recruiting at 303 sites Phase 2 SWOG Cancer Research Network · Birmingham, Alabama and 330 other locations · NCT04511013

• Exploring gut microbiome and fecal transplant effects on GI issues in cancer patients

  This study is testing how the gut bacteria affect stomach issues in cancer patients receiving certain treatments and whether a stool transplant can help relieve those problems.

  Recruiting Phase 1 M.D. Anderson Cancer Center · Houston, Texas · NCT03819296

Related topics

Quick answers

How many Clinical Stage IV Cutaneous Melanoma AJCC v8 clinical trials are recruiting right now?

13, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

All of them have sites in United States. Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 1: 4, Phase 1/2: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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