Condition

Metastatic Malignant Solid Neoplasm clinical trials and research

• 46Clinical trials
• 3Countries

Newest Metastatic Malignant Solid Neoplasm clinical trials

All recruiting trials (46)

• Adding targeted GRID-style radiation to standard palliative therapy for unresectable solid tumors

  This study tests whether adding spatially fractionated radiation therapy to standard palliative radiation helps relieve symptoms in patients with unresectable solid tumors.

  Recruiting at 2 sites Mayo Clinic · Scottsdale, Arizona and 1 other locations · NCT07856394

• BMS-986504 plus pemetrexed for MTAP-deleted metastatic solid tumors

  This study tests whether the combination of BMS-986504 and pemetrexed is safe and potentially effective for people with MTAP-deleted metastatic solid tumors.

  Recruiting Phase 1/2 Northwestern University · Chicago, Illinois · NCT07594626

• Morning versus afternoon immunotherapy for advanced or metastatic solid tumors

  This trial tests whether giving standard immune checkpoint inhibitor therapy in the morning versus the afternoon changes outcomes for adults with advanced or metastatic solid tumors.

  Recruiting Phase 4 OHSU Knight Cancer Institute · Portland, Oregon · NCT07405086

• TR-002 (Nadofaragene Firadenovec) given by IV for adults with advanced unresectable or metastatic solid tumors and refractory metastatic pancreatic adenocarcinoma

  This Phase 1 trial tests whether weekly intravenous TR-002 is safe and what dose is best for adults with advanced unresectable or metastatic solid tumors or refractory metastatic pancreatic cancer.

  Recruiting Phase 1 University of California, Davis · Sacramento, California · NCT07189195

• Safety of combining pidnarulex (CX-5461) with trastuzumab deruxtecan for HER2-positive, HER2-low/ultralow breast and other HER2-expressing solid tumors

  This trial tests whether adding pidnarulex to trastuzumab deruxtecan is safe and finds the best dose for adults with HER2-positive, HER2-low/ultralow, or other HER2-expressing advanced or metastatic breast and solid tumors.

  Recruiting at 2 sites Phase 1 National Cancer Institute (NCI) · Boston, Massachusetts and 1 other locations · NCT07137416

• Using 18F-TRX to image solid tumors

  This trial tests whether the 18F-TRX PET tracer can detect tumors in adults with advanced solid tumors such as high‑grade glioma, clear cell renal cell carcinoma, or metastatic castration‑resistant prostate cancer.

  Recruiting Phase 1 University of California, San Francisco · San Francisco, California · NCT06942104

• MTI-301 for advanced, unresectable, or treatment-resistant solid tumors

  This phase 1 test gives the oral drug MTI-301 to adults with metastatic, unresectable, or treatment-resistant solid cancers to find the safest dose and monitor side effects.

  Recruiting Phase 1 Mayo Clinic · Jacksonville, Florida · NCT06911008

• Using pemetrexed to treat metastatic bladder cancer and other solid tumors with specific gene mutations

  This study is testing if the drug pemetrexed can help people with advanced bladder cancer and other solid tumors that have certain gene mutations.

  Recruiting at 2 sites Phase 2 Northwestern University · Chicago, Illinois and 1 other locations · NCT06630416

• Testing the drug CX-5461 in patients with metastatic solid cancers

  This study is testing a new drug called CX-5461 in patients with advanced solid cancers to see if it can help shrink tumors and how safe it is to use.

  Recruiting Phase 1 National Cancer Institute (NCI) · Bethesda, Maryland · NCT06606990

• Biology-guided radiation therapy for painful bone metastases

  This study is testing a new type of radiation therapy to see if it can help people with painful bone cancer feel less pain and improve their quality of life.

  Recruiting Phase 1 City of Hope Medical Center · Duarte, California · NCT06549478

• Combining two anticancer drugs for treating advanced gastric and gastroesophageal junction cancers

  This study is testing a new combination of two cancer drugs to see if they can help people with advanced HER2-positive gastric or gastroesophageal junction cancers feel better and live longer.

  Recruiting Phase 1 National Cancer Institute (NCI) · Houston, Texas · NCT06364410

• Predicting how tumors respond to immune therapies using a live diagnostic platform

  This study is testing a new way to predict how well immune therapies will work for patients with different types of solid tumors, including early-stage and metastatic cancers.

  Recruiting at 3 sites Mayo Clinic · Phoenix, Arizona and 2 other locations · NCT06349642

• Using arginine with whole brain radiation therapy for brain metastases treatment

  This study is testing if taking arginine, either by mouth or through an IV, can help improve the effectiveness of whole brain radiation therapy for people with brain metastases.

  Recruiting Early Phase 1 Emory University · Atlanta, Georgia · NCT06328686

• Combining axatilimab, retifanlimab, and paclitaxel for advanced solid tumors

  This study is testing a new combination of three medications to see if they can help people with advanced solid tumors feel better and improve their treatment outcomes.

  Recruiting Phase 1/2 OHSU Knight Cancer Institute · Portland, Oregon · NCT06320405

• Personalized treatment for advanced solid tumors using antibody-drug conjugates

  This study is testing if personalized treatments using special antibody-drug combinations can help people with advanced solid tumors that have certain proteins.

  Recruiting at 29 sites Phase 2 National Cancer Institute (NCI) · Duarte, California and 28 other locations · NCT06311214

• Evaluating TAK-243 for advanced cancer treatment

  This study is testing a new drug called TAK-243 to see if it can safely help people with advanced cancer by looking at how it affects their tumors and overall health.

  Recruiting Phase 1 National Cancer Institute (NCI) · Bethesda, Maryland · NCT06223542

• Monitoring T Cell Responses in Cancer Patients Receiving Anti-PD-1 Therapy

  This study is trying to see how T cells in the blood can help doctors understand how well anti-PD-1 therapy works for people with melanoma, lung cancer, and other cancers.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT06075524

• Group sessions to help cancer patients manage stress

  This study is testing if group sessions that teach cancer patients how to manage stress can help them feel better mentally and cope with their treatment.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT06015932

• Combining ZEN003694 with Capecitabine for Advanced Cancer Treatment

  This study is testing a new combination of two cancer drugs, ZEN003694 and capecitabine, to see if it can help people with advanced cancers that haven't responded to other treatments.

  Recruiting at 16 sites Phase 1 National Cancer Institute (NCI) · Irvine, California and 21 other locations · NCT05803382

• Using advanced radiation therapy to treat patients with multiple metastatic tumors

  This study is testing a new type of targeted radiation therapy to see if it can safely help patients with multiple tumors feel better while protecting healthy tissue.

  Recruiting Early Phase 1 City of Hope Medical Center · Duarte, California · NCT05733949

• Testing CBX-12 for advanced solid cancers

  This study is testing a new drug called CBX-12 to see if it can help people with advanced solid tumors by killing cancer cells more effectively than current treatments.

  Recruiting Phase 1 National Cancer Institute (NCI) · Bethesda, Maryland · NCT05691517

• Combining Temozolomide and M1774 to Treat Advanced Cancer

  This study is testing a combination of two cancer drugs, temozolomide and M1774, to see if they can help people with advanced metastatic cancers feel better and improve their treatment outcomes.

  Recruiting at 15 sites Phase 1/2 National Cancer Institute (NCI) · Irvine, California and 22 other locations · NCT05691491

• Combining two anti-cancer drugs for advanced solid tumors

  This study is testing if a combination of two anti-cancer drugs can be safely used to help people with advanced solid tumors that have spread.

  Recruiting at 6 sites Phase 1 National Cancer Institute (NCI) · Bethesda, Maryland and 6 other locations · NCT05687136

• Testing novobiocin for cancer patients with DNA repair gene alterations

  This study is testing a drug called novobiocin to see if it can help cancer patients with certain gene changes in their tumors feel better and fight their cancer.

  Recruiting at 18 sites Phase 1 National Cancer Institute (NCI) · Duarte, California and 22 other locations · NCT05687110

• Targeted therapy for advanced solid tumors based on genetic testing

  This study is testing whether matching patients with advanced solid tumors to specific treatments based on their genetic makeup can improve their outcomes when standard options have failed.

  Recruiting at 437 sites Phase 2 National Cancer Institute (NCI) · Birmingham, Alabama and 483 other locations · NCT05564377

• Identifying Diagnostic Markers in Patients with Metastatic Cancer

  This study is trying to find new markers in blood and tissue samples from patients with metastatic cancer to see if they can help guide better treatments.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT05530759

• Combining two anti-cancer drugs for patients with advanced tumors

  This study is testing a new combination of two anti-cancer drugs to see if it can help teenagers and adults with advanced tumors feel better and improve their treatment options.

  Recruiting at 7 sites Phase 1 National Cancer Institute (NCI) · Los Angeles, California and 6 other locations · NCT05372640

• Testing a combination of two anti-cancer drugs for HER2-positive solid tumors

  This study is testing a combination of two cancer drugs to see if they can safely help people with advanced HER2-positive solid tumors.

  Recruiting at 15 sites Phase 1 National Cancer Institute (NCI) · Duarte, California and 17 other locations · NCT05372614

• Evaluating CD8 PET Imaging for Immune Response in Cancer Treatment

  This study is testing if a special type of radiation therapy can boost immune cells in patients with lymphoma and solid tumors, while also checking if a new imaging method can safely track these changes.

  Recruiting Phase 1 City of Hope Medical Center · Duarte, California · NCT05371132

• Personalized vaccine combined with pembrolizumab for advanced solid tumors

  This study is testing a new personalized cancer vaccine combined with pembrolizumab to see if it helps people with advanced solid tumors fight their cancer better.

  Recruiting Phase 1/2 Mayo Clinic · Jacksonville, Florida · NCT05269381

• Comparing single and fractionated stereotactic radiosurgery for brain metastases treatment

  This study is testing whether a single session of targeted radiation or multiple sessions is better for treating patients with brain tumors that have spread from other cancers.

  Recruiting at 6 sites Phase 2 Mayo Clinic · Scottsdale, Arizona and 6 other locations · NCT05222620

• Combining ZEN003694 and Binimetinib for Advanced Solid Tumors with RAS Alterations

  This study is testing a combination of two cancer drugs, ZEN003694 and binimetinib, to see if they can help people with advanced solid tumors that have RAS changes.

  Recruiting Phase 1 National Cancer Institute (NCI) · Boston, Massachusetts and 3 other locations · NCT05111561

• Personalized vaccine treatment for advanced melanoma, breast cancer, and lung cancer

  This study is testing a personalized vaccine combined with a treatment called nivolumab to see if it can help people with advanced melanoma, breast cancer, or lung cancer fight their tumors better.

  Recruiting Phase 1 Fred Hutchinson Cancer Center · Seattle, Washington · NCT05098210

• Parenting support for families dealing with advanced cancer

  This study is testing a new parenting support program for families dealing with advanced cancer to see if it helps them cope better than standard care.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT05059678

• Combining NBTXR3 with radiation and immunotherapy for advanced solid tumors

  This study is testing a new treatment using NBTXR3 along with radiation and immunotherapy to see if it helps people with advanced solid tumors that have spread to the lungs or liver.

  Recruiting Phase 1/2 M.D. Anderson Cancer Center · Houston, Texas · NCT05039632

• Treatment of advanced solid tumors with larotrectinib for NTRK gene amplification

  This study is testing if a new drug called larotrectinib can help people with advanced solid tumors that have a specific gene change called NTRK amplification.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT04879121

• Avapritinib for treating advanced solid tumors with specific mutations

  This study is testing if a new drug called avapritinib can help people with advanced solid tumors that have specific mutations feel better and live longer after other treatments haven't worked.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT04771520

• Combining talazoparib with palbociclib, axitinib, or crizotinib for advanced solid tumors

  This study is testing a new combination of drugs for people with advanced solid tumors to see which mix works best and is safest to use.

  Recruiting Phase 1 M.D. Anderson Cancer Center · Houston, Texas · NCT04693468

• Combining cryoablation and radiation therapy for painful bone metastases

  This study is testing if combining a freezing treatment with radiation can help people with painful bone cancer feel better compared to just using radiation alone.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT04693377

• Combining DS-8201a and Olaparib for HER2-Expressing Cancers

  This study is testing a new combination of two drugs, DS-8201a and olaparib, to see if it can help people with HER2-expressing cancers, especially those with ovarian cancer that hasn't responded to other treatments.

  Recruiting at 12 sites Phase 1 National Cancer Institute (NCI) · Phoenix, Arizona and 12 other locations · NCT04585958

• Mobile app to help cancer patients with advance care planning

  This study tests whether a mobile app can help cancer patients talk about and plan their future care wishes with their families and doctors better than standard care alone.

  Recruiting Fred Hutchinson Cancer Center · Manhasset, New York and 3 other locations · NCT04515810

• Using pressurized aerosol chemotherapy to treat advanced abdominal cancers

  This study is testing a new way to deliver chemotherapy directly into the abdomen using a special aerosol spray to see if it helps people with advanced abdominal cancers feel better and have fewer side effects.

  Recruiting at 2 sites Phase 1 City of Hope Medical Center · Duarte, California and 2 other locations · NCT04329494

• Gene modified immune cells for treating advanced melanoma and metastatic solid tumors

  This study is testing if modified immune cells can safely target and attack advanced melanoma and other solid tumors in patients after they receive chemotherapy.

  Recruiting at 3 sites Phase 1 Stanford University · Duarte, California and 2 other locations · NCT04119024

• Combining durvalumab with chemotherapy for advanced solid tumors

  This study is testing if combining an immunotherapy drug called durvalumab with standard chemotherapy can help people with advanced solid tumors by improving their immune response and slowing down tumor growth.

  Recruiting Phase 2 National Cancer Institute (NCI) · Bethesda, Maryland · NCT03907475

• Evaluating brain function in patients with multiple brain tumors treated with targeted radiation

  This study is testing whether a specific type of radiation treatment for multiple brain tumors helps patients keep their thinking skills and quality of life better than another type of radiation.

  Recruiting Thomas Jefferson University · Sewell, New Jersey and 1 other locations · NCT03184038

• Collecting and storing tissue and blood samples from cancer patients

  This study is collecting and storing blood and tissue samples from cancer patients to help researchers create better models for understanding cancer and testing new treatments.

  Recruiting at 18 sites National Cancer Institute (NCI) · Birmingham, Alabama and 139 other locations · NCT02474160

Related topics

Quick answers

How many Metastatic Malignant Solid Neoplasm clinical trials are recruiting right now?

46, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 3 countries. The most sites are in United States (46 trials), Canada (1 trial), Puerto Rico (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 21, Phase 2: 7, Phase 1/2: 5, Early Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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