Condition

Metastatic Head and Neck Squamous Cell Carcinoma clinical trials and research

• 17Clinical trials
• 33Countries

Newest Metastatic Head and Neck Squamous Cell Carcinoma clinical trials

All recruiting trials (17)

• Ficerafusp alfa (BCA101) with pembrolizumab in first-line PD-L1-positive recurrent/metastatic HNSCC: alternative dosing vs weekly dosing

  This study tests whether a different dosing approach of ficerafusp alfa plus pembrolizumab works as well as the standard weekly dosing in adults with newly diagnosed or recurrent/metastatic PD-L1-positive head and neck cancer.

  Recruiting at 7 sites Phase 2 Bicara Therapeutics · Fort Myers, Florida and 6 other locations · NCT07807163

• Morning versus afternoon immunotherapy for advanced or metastatic solid tumors

  This trial tests whether giving standard immune checkpoint inhibitor therapy in the morning versus the afternoon changes outcomes for adults with advanced or metastatic solid tumors.

  Recruiting Phase 4 OHSU Knight Cancer Institute · Portland, Oregon · NCT07405086

• Using [18F]NOTA-ABY030 PET/CT to clarify indeterminate head and neck squamous cell carcinoma lesions

  This trial will test whether the new PET imaging agent [18F]NOTA-ABY030 is safe and can better detect unclear primary or metastatic lesions in adults with head and neck squamous cell carcinoma.

  Recruiting Phase 1 Vanderbilt-Ingram Cancer Center · Nashville, Tennessee · NCT07217028

• Autologous tumor membrane vesicle (TMV) vaccine alone or with pembrolizumab for recurrent or metastatic head and neck squamous cell carcinoma

  This trial tests whether a vaccine made from a patient's own tumor (TMV), given alone or with pembrolizumab, can help people with recurrent or metastatic head and neck squamous cell carcinoma who had tumor tissue banked at surgery.

  Recruiting at 2 sites Phase 1 Emory University · Atlanta, Georgia and 1 other locations · NCT06868433

• Evaluating ficerafusp alfa with pembrolizumab for advanced head and neck cancer

  This study is testing a new treatment combining ficerafusp alfa and pembrolizumab to see if it helps people with advanced head and neck cancer feel better.

  Recruiting at 231 sites Phase 2/3 Bicara Therapeutics · Birmingham, Alabama and 230 other locations · NCT06788990

• Remote hearing tests for patients with head and neck cancer receiving chemotherapy or radiation

  This study is testing if remote hearing tests can help patients with advanced head and neck cancer keep track of their hearing loss during chemotherapy or radiation, making it easier for those who live far away to participate.

  Recruiting Emory University · Atlanta, Georgia · NCT06662058

• Combining lovastatin and pembrolizumab for advanced head and neck cancer treatment

  This study is testing if combining a cholesterol-lowering drug called lovastatin with an immunotherapy drug called pembrolizumab can help people with advanced head and neck cancer feel better and live longer.

  Recruiting at 2 sites Phase 2 Emory University · Atlanta, Georgia and 1 other locations · NCT06636734

• Combining cetuximab with pembrolizumab for advanced head and neck cancer

  This study is testing if adding cetuximab to pembrolizumab can help people with advanced head and neck cancer live longer and feel better compared to just using pembrolizumab alone.

  Recruiting at 192 sites Phase 3 National Cancer Institute (NCI) · Little Rock, Arkansas and 201 other locations · NCT06589804

• Comparing home and clinic administration of nivolumab for cancer treatment

  This study tests whether giving cancer patients their treatment at home instead of in a clinic makes them feel better and prefer their care more.

  Recruiting Phase 2 Mayo Clinic · Jacksonville, Florida · NCT06265285

• Combination treatment for advanced head and neck cancer

  This study is testing a new combination treatment for people with advanced head and neck cancer to see if it can boost their immune response and help fight the disease.

  Recruiting at 2 sites Phase 2 Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT06239220

• Combination treatment for recurrent head and neck cancer

  This study is testing a new combination of medications and radiation to see if it helps people with tough-to-treat head and neck cancer feel better and live longer.

  Recruiting at 2 sites Phase 1 University of California, Davis · Sacramento, California and 1 other locations · NCT06211335

• Combining ficlatuzumab with cetuximab for advanced HPV-negative head and neck cancer

  This study is testing if adding a new drug called ficlatuzumab to cetuximab can help people with advanced HPV-negative head and neck cancer live longer and feel better compared to just using cetuximab with a placebo.

  Recruiting at 96 sites Phase 3 AVEO Pharmaceuticals, Inc. · Gilbert, Arizona and 111 other locations · NCT06064877

• Using a new imaging agent to detect metastases in head and neck cancer

  This study is testing a new imaging agent to see if it can help find hidden cancer spread in people with head and neck cancer better than current methods.

  Recruiting Phase 1 Vanderbilt-Ingram Cancer Center · Nashville, Tennessee · NCT05747625

• Personalized vaccine combined with pembrolizumab for advanced solid tumors

  This study is testing a new personalized cancer vaccine combined with pembrolizumab to see if it helps people with advanced solid tumors fight their cancer better.

  Recruiting Phase 1/2 Mayo Clinic · Jacksonville, Florida · NCT05269381

• Combining cabozantinib and nivolumab to treat advanced melanoma and head and neck cancer

  This study is testing a combination of two cancer drugs, cabozantinib and nivolumab, to see if they can help people with advanced melanoma or head and neck cancer while also looking at how to better match treatments to patients based on their tumor characteristics.

  Recruiting at 211 sites Phase 2 National Cancer Institute (NCI) · Phoenix, Arizona and 231 other locations · NCT05136196

• Combination treatment for advanced head and neck cancer using radiation and immunotherapy

  This study is testing a new treatment for advanced head and neck cancer that combines a special type of radiation with an immunotherapy drug to see if it helps patients with hard-to-treat tumors.

  Recruiting at 2 sites Alpha Tau Medical LTD. · Jerusalem and 2 other locations · NCT05047094

• Cetuximab treatment for advanced head and neck cancer after immunotherapy

  This study is testing if the drug Cetuximab can help people with advanced head and neck cancer who didn’t respond to or couldn’t tolerate previous immunotherapy treatments.

  Recruiting Phase 2 Wake Forest University Health Sciences · Winston-Salem, North Carolina · NCT04375384

Related topics

Quick answers

How many Metastatic Head and Neck Squamous Cell Carcinoma clinical trials are recruiting right now?

17, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 33 countries. The most sites are in United States (16 trials), Australia (2 trials), Belgium (2 trials), Canada (2 trials), Czechia (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 6, Phase 1: 4, Phase 3: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →