Condition

Refractory Malignant Solid Neoplasm clinical trials and research

• 10Clinical trials
• 3Countries

Newest Refractory Malignant Solid Neoplasm clinical trials

All recruiting trials (10)

• MTI-301 for advanced, unresectable, or treatment-resistant solid tumors

  This phase 1 test gives the oral drug MTI-301 to adults with metastatic, unresectable, or treatment-resistant solid cancers to find the safest dose and monitor side effects.

  Recruiting Phase 1 Mayo Clinic · Jacksonville, Florida · NCT06911008

• Combining axatilimab, retifanlimab, and paclitaxel for advanced solid tumors

  This study is testing a new combination of three medications to see if they can help people with advanced solid tumors feel better and improve their treatment outcomes.

  Recruiting Phase 1/2 OHSU Knight Cancer Institute · Portland, Oregon · NCT06320405

• Evaluating TAK-243 for advanced cancer treatment

  This study is testing a new drug called TAK-243 to see if it can safely help people with advanced cancer by looking at how it affects their tumors and overall health.

  Recruiting Phase 1 National Cancer Institute (NCI) · Bethesda, Maryland · NCT06223542

• Using AOH1996 to treat hard-to-treat solid tumors

  This study is testing a new drug called AOH1996 to see if it is safe and effective for people with hard-to-treat solid tumors like certain sarcomas and ovarian cancer.

  Recruiting at 2 sites Phase 1 City of Hope Medical Center · Scottsdale, Arizona and 2 other locations · NCT05227326

• Combining ZEN003694 and Binimetinib for Advanced Solid Tumors with RAS Alterations

  This study is testing a combination of two cancer drugs, ZEN003694 and binimetinib, to see if they can help people with advanced solid tumors that have RAS changes.

  Recruiting Phase 1 National Cancer Institute (NCI) · Boston, Massachusetts and 3 other locations · NCT05111561

• Testing a new drug combination for advanced cancer and lymphoma

  This study is testing a new combination of two drugs to see if it can help people with advanced cancer and lymphoma feel better and live longer.

  Recruiting at 3 sites Phase 1/2 National Cancer Institute (NCI) · New Haven, Connecticut and 2 other locations · NCT05053971

• Onivyde combined with talazoparib or temozolomide for children and young adults with recurrent solid tumors and Ewing sarcoma

  This will test whether adding talazoparib or temozolomide to Onivyde helps children and young adults whose solid tumors or Ewing sarcoma have come back.

  Recruiting at 8 sites Phase 1/2 St. Jude Children's Research Hospital · Palo Alto, California and 9 other locations · NCT04901702

• CBL0137 treatment for relapsed or refractory solid tumors and CNS tumors

  This study is testing a new treatment called CBL0137 to see if it can help children and young adults with tough-to-treat solid tumors and brain tumors feel better.

  Recruiting at 33 sites Phase 1/2 Children's Oncology Group · Birmingham, Alabama and 34 other locations · NCT04870944

• Tegavivint treatment for recurrent or refractory solid tumors in children

  This study tests if a new intravenous medication called tegavivint can help children with tough-to-treat solid tumors, like Ewing sarcoma and desmoid tumors, by finding the right dose and seeing how well it works.

  Recruiting at 19 sites Phase 1/2 Children's Oncology Group · Birmingham, Alabama and 20 other locations · NCT04851119

• Gene modified immune cells for treating advanced melanoma and metastatic solid tumors

  This study is testing if modified immune cells can safely target and attack advanced melanoma and other solid tumors in patients after they receive chemotherapy.

  Recruiting at 3 sites Phase 1 Stanford University · Duarte, California and 2 other locations · NCT04119024

Related topics

Quick answers

How many Refractory Malignant Solid Neoplasm clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 3 countries. The most sites are in United States (10 trials), Canada (1 trial), Australia (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 5, Phase 1: 5. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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