Condition

Unresectable Malignant Solid Neoplasm clinical trials and research

• 14Clinical trials
• 3Countries

Newest Unresectable Malignant Solid Neoplasm clinical trials

All recruiting trials (14)

• Adding targeted GRID-style radiation to standard palliative therapy for unresectable solid tumors

  This study tests whether adding spatially fractionated radiation therapy to standard palliative radiation helps relieve symptoms in patients with unresectable solid tumors.

  Recruiting at 2 sites Mayo Clinic · Scottsdale, Arizona and 1 other locations · NCT07856394

• TR-002 (Nadofaragene Firadenovec) given by IV for adults with advanced unresectable or metastatic solid tumors and refractory metastatic pancreatic adenocarcinoma

  This Phase 1 trial tests whether weekly intravenous TR-002 is safe and what dose is best for adults with advanced unresectable or metastatic solid tumors or refractory metastatic pancreatic cancer.

  Recruiting Phase 1 University of California, Davis · Sacramento, California · NCT07189195

• Safety of combining pidnarulex (CX-5461) with trastuzumab deruxtecan for HER2-positive, HER2-low/ultralow breast and other HER2-expressing solid tumors

  This trial tests whether adding pidnarulex to trastuzumab deruxtecan is safe and finds the best dose for adults with HER2-positive, HER2-low/ultralow, or other HER2-expressing advanced or metastatic breast and solid tumors.

  Recruiting at 2 sites Phase 1 National Cancer Institute (NCI) · Boston, Massachusetts and 1 other locations · NCT07137416

• MTI-301 for advanced, unresectable, or treatment-resistant solid tumors

  This phase 1 test gives the oral drug MTI-301 to adults with metastatic, unresectable, or treatment-resistant solid cancers to find the safest dose and monitor side effects.

  Recruiting Phase 1 Mayo Clinic · Jacksonville, Florida · NCT06911008

• Combining two anticancer drugs for treating advanced gastric and gastroesophageal junction cancers

  This study is testing a new combination of two cancer drugs to see if they can help people with advanced HER2-positive gastric or gastroesophageal junction cancers feel better and live longer.

  Recruiting Phase 1 National Cancer Institute (NCI) · Houston, Texas · NCT06364410

• Combining ZEN003694 with Capecitabine for Advanced Cancer Treatment

  This study is testing a new combination of two cancer drugs, ZEN003694 and capecitabine, to see if it can help people with advanced cancers that haven't responded to other treatments.

  Recruiting at 16 sites Phase 1 National Cancer Institute (NCI) · Irvine, California and 21 other locations · NCT05803382

• Combining two anti-cancer drugs for advanced solid tumors

  This study is testing if a combination of two anti-cancer drugs can be safely used to help people with advanced solid tumors that have spread.

  Recruiting at 6 sites Phase 1 National Cancer Institute (NCI) · Bethesda, Maryland and 6 other locations · NCT05687136

• Testing novobiocin for cancer patients with DNA repair gene alterations

  This study is testing a drug called novobiocin to see if it can help cancer patients with certain gene changes in their tumors feel better and fight their cancer.

  Recruiting at 18 sites Phase 1 National Cancer Institute (NCI) · Duarte, California and 22 other locations · NCT05687110

• Targeted therapy for advanced solid tumors based on genetic testing

  This study is testing whether matching patients with advanced solid tumors to specific treatments based on their genetic makeup can improve their outcomes when standard options have failed.

  Recruiting at 437 sites Phase 2 National Cancer Institute (NCI) · Birmingham, Alabama and 483 other locations · NCT05564377

• Combining two anti-cancer drugs for patients with advanced tumors

  This study is testing a new combination of two anti-cancer drugs to see if it can help teenagers and adults with advanced tumors feel better and improve their treatment options.

  Recruiting at 7 sites Phase 1 National Cancer Institute (NCI) · Los Angeles, California and 6 other locations · NCT05372640

• Testing a combination of two anti-cancer drugs for HER2-positive solid tumors

  This study is testing a combination of two cancer drugs to see if they can safely help people with advanced HER2-positive solid tumors.

  Recruiting at 15 sites Phase 1 National Cancer Institute (NCI) · Duarte, California and 17 other locations · NCT05372614

• Personalized vaccine combined with pembrolizumab for advanced solid tumors

  This study is testing a new personalized cancer vaccine combined with pembrolizumab to see if it helps people with advanced solid tumors fight their cancer better.

  Recruiting Phase 1/2 Mayo Clinic · Jacksonville, Florida · NCT05269381

• Combining ZEN003694 and Binimetinib for Advanced Solid Tumors with RAS Alterations

  This study is testing a combination of two cancer drugs, ZEN003694 and binimetinib, to see if they can help people with advanced solid tumors that have RAS changes.

  Recruiting Phase 1 National Cancer Institute (NCI) · Boston, Massachusetts and 3 other locations · NCT05111561

• Combining DS-8201a and Olaparib for HER2-Expressing Cancers

  This study is testing a new combination of two drugs, DS-8201a and olaparib, to see if it can help people with HER2-expressing cancers, especially those with ovarian cancer that hasn't responded to other treatments.

  Recruiting at 12 sites Phase 1 National Cancer Institute (NCI) · Phoenix, Arizona and 12 other locations · NCT04585958

Related topics

Quick answers

How many Unresectable Malignant Solid Neoplasm clinical trials are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 3 countries. The most sites are in United States (14 trials), Canada (1 trial), Puerto Rico (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 11, Phase 1/2: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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