Condition

Anatomic Stage IV Breast Cancer AJCC v8 clinical trials and research

• 43Clinical trials
• 3Countries

Newest Anatomic Stage IV Breast Cancer AJCC v8 clinical trials

All recruiting trials (43)

• Blended e-Health Program to Help Women with Breast or Gynecologic Cancer Manage Fear of Cancer Progression

  This trial tests a blended online and group program to see if it helps women with breast or gynecologic cancer feel less fear that their cancer could grow or spread.

  Recruiting at 11 sites City of Hope Medical Center · Arcadia, California and 10 other locations · NCT07741968

• Couples Coping Together Against Cancer: A Feasibility and Acceptability Look

  This observational study tests whether a brokered program for patients with cancer and their partners is feasible and acceptable, and whether it may reduce distress over time.

  Recruiting City of Hope Medical Center · Duarte, California · NCT07664579

• Adding Surgery and Radiation to Standard Therapy for HER2+ Stage IV Breast Cancer

  This study tests whether adding surgery, radiation, and targeted ablative radiotherapy to the usualHER2-directed systemic therapy helps patients with newly diagnosed oligometastatic HER2-positive breast cancer more than standard systemic therapy alone.

  Recruiting at 59 sites Phase 3 SWOG Cancer Research Network · Jonesboro, Arkansas and 58 other locations · NCT07578116

• Living Well with Advanced Breast Cancer: Understanding Supportive Care Needs

  This project asks adults with advanced (stage IV) breast cancer and their caregivers about what supportive care has helped, what’s been hard, and what help they still need.

  Recruiting Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT07227038

• Leuprolide versus goserelin to stop ovarian estrogen production in pre- or peri-menopausal women with breast cancer

  This study tests whether two doses of leuprolide or goserelin better stops the ovaries from making estrogen in pre- or peri-menopausal women with breast cancer.

  Recruiting Phase 2 University of Michigan Rogel Cancer Center · Ann Arbor, Michigan · NCT07158021

• Safety of combining pidnarulex (CX-5461) with trastuzumab deruxtecan for HER2-positive, HER2-low/ultralow breast and other HER2-expressing solid tumors

  This trial tests whether adding pidnarulex to trastuzumab deruxtecan is safe and finds the best dose for adults with HER2-positive, HER2-low/ultralow, or other HER2-expressing advanced or metastatic breast and solid tumors.

  Recruiting at 2 sites Phase 1 National Cancer Institute (NCI) · Boston, Massachusetts and 1 other locations · NCT07137416

• STEMVAC vaccine with hormone therapy plus CDK4/6 inhibitor or capecitabine for metastatic HR-positive, HER2-negative breast cancer

  This trial tests whether adding the STEMVAC vaccine to standard hormone therapy with a CDK4/6 drug, or to capecitabine chemotherapy, helps people with metastatic hormone receptor–positive, HER2‑negative breast cancer.

  Recruiting Phase 2 University of Washington · Seattle, Washington · NCT07112053

• STEMVAC vaccine plus chemotherapy for PD-L1 negative metastatic triple-negative breast cancer.

  This trial will try giving the STEMVAC cancer vaccine together with standard chemotherapy to adults with PD‑L1 negative metastatic triple‑negative breast cancer to boost the immune system against the tumor.

  Recruiting Phase 2 University of Washington · Seattle, Washington · NCT07078604

• Optimized ultrasound twinkling marker to image axillary lymph nodes in clinically node-positive breast cancer

  This trial tests an improved ultrasound twinkling marker to help doctors reliably see cancer-containing lymph nodes by ultrasound in people with biopsy-proven node-positive breast cancer.

  Recruiting Phase 1 Mayo Clinic · Rochester, Minnesota · NCT06999798

• Photon VMAT craniospinal radiation for leptomeningeal disease from breast or non‑small cell lung cancer

  This trial tests whether craniospinal irradiation delivered with photon VMAT can help adults whose breast cancer or non‑small cell lung cancer has spread to the meninges (leptomeningeal disease).

  Recruiting at 2 sites Phase 2 City of Hope Medical Center · Duarte, California and 1 other locations · NCT06910761

• Cemiplimab plus Y-90 radioembolization for breast cancer that has spread to the liver

  This trial tests whether giving the immunotherapy cemiplimab together with Y-90 liver radioembolization can boost immune attack and shrink tumors in people whose breast cancer has spread mainly to the liver.

  Recruiting Phase 2 City of Hope Medical Center · Duarte, California · NCT06860815

• Adaptive capecitabine therapy for metastatic ER-positive, HER2-negative breast cancer

  This trial will try using capecitabine with dose changes based on tumor imaging and blood markers in adults with metastatic ER-positive, HER2-negative breast cancer.

  Recruiting Phase 2 Mayo Clinic · Scottsdale, Arizona · NCT06525766

• Hippocampal avoidance during craniospinal irradiation for breast and lung cancer with leptomeningeal metastases

  This study is testing a new way of giving radiation therapy to help people with breast or lung cancer that has spread to their brain, aiming to reduce symptoms while protecting their memory.

  Recruiting at 2 sites Phase 2 University of Washington · San Francisco, California and 2 other locations · NCT06518057

• [18F]FTT PET to image PARP expression in metastatic breast cancer

  This test tries to see if an [18F]FTT PET scan can show PARP levels and help detect whether PARP inhibitor treatment (with or without immunotherapy) is working for people with metastatic breast cancer.

  Recruiting Phase 1/2 University of Washington · Seattle, Washington · NCT06502691

• Comparing proton radiation therapy to standard radiation for leptomeningeal metastasis

  This study is testing whether proton radiation therapy is better than standard radiation for people with leptomeningeal metastasis from breast or lung cancer to see if it helps them live longer and stay healthier.

  Recruiting at 58 sites Phase 3 NRG Oncology · Phoenix, Arizona and 57 other locations · NCT06500481

• High-dose radiation combined with pembrolizumab and chemotherapy for PD-L1 positive metastatic triple-negative breast cancer

  This trial tests whether giving high-dose radiation to a few metastatic sites together with pembrolizumab and chemotherapy helps people with PD-L1 positive metastatic triple-negative breast cancer live longer without their disease getting worse.

  Recruiting Phase 2 Emory University · Atlanta, Georgia · NCT06492759

• Tamoxifen plus pegylated liposomal doxorubicin for advanced triple-negative breast cancer

  This trial tests whether combining tamoxifen with pegylated liposomal doxorubicin can shrink or control metastatic or inoperable locally advanced triple-negative breast cancer in patients with low ER expression and a confirmed TP53 genomic alteration who have had prior therapies.

  Recruiting Phase 2 Roswell Park Cancer Institute · Buffalo, New York · NCT06434064

• Measuring a biomarker for breast cancer treatment effectiveness

  This study is testing if measuring a specific biomarker can help doctors understand how well hormone treatments are working for people with advanced breast cancer.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT06388122

• Personalized tumor vaccine with checkpoint inhibitors for triple negative breast cancer

  This phase I trial will test whether a personalized tumor membrane vesicle (TMV) vaccine, given alone or with pembrolizumab or ipilimumab, can boost immune response and help control disease in adults with triple negative breast cancer.

  Recruiting at 4 sites Phase 1 Emory University · Atlanta, Georgia and 3 other locations · NCT06324240

• Using targeted radiation therapy for treating specific metastatic breast cancer cases

  This study is testing if a targeted radiation treatment can help people with certain types of metastatic breast cancer keep taking their regular medication for at least 24 weeks while also checking how it affects their safety and quality of life.

  Recruiting at 2 sites Phase 2 City of Hope Medical Center · Duarte, California and 1 other locations · NCT06260033

• Using imaging to predict response to abemaciclib in advanced breast cancer

  This study is testing if special imaging can help doctors figure out which patients with advanced breast cancer will respond best to a new treatment combining abemaciclib and hormone therapy.

  Recruiting at 3 sites Phase 2 University of Washington · St Louis, Missouri and 2 other locations · NCT06179303

• Gemcitabine and NK cells with or without Naxitamab for metastatic HER2-negative breast cancer

  This study is testing a new treatment using gemcitabine and special immune cells, with or without naxitamab, to see if it helps people with advanced HER2-negative breast cancer feel better and live longer.

  Recruiting Phase 1/2 Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT06026657

• Using electric fields to treat spinal cancer spread in breast cancer patients

  This study tests if wearing a portable device that uses electric fields can help breast cancer patients whose cancer has spread to the spine feel better and slow down tumor growth.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT05746325

• Using propranolol and pembrolizumab to treat resistant triple negative breast cancer

  This study is testing if adding propranolol to pembrolizumab can help people with hard-to-treat triple negative breast cancer respond better to their treatment.

  Recruiting Phase 2 Emory University · Atlanta, Georgia and 1 other locations · NCT05741164

• Targeted therapy for advanced solid tumors based on genetic testing

  This study is testing whether matching patients with advanced solid tumors to specific treatments based on their genetic makeup can improve their outcomes when standard options have failed.

  Recruiting at 437 sites Phase 2 National Cancer Institute (NCI) · Birmingham, Alabama and 483 other locations · NCT05564377

• Combining ZEN003694 and Pembrolizumab with Standard Chemotherapy for Advanced Triple-Negative Breast Cancer

  This study is testing a new combination of a targeted drug and immunotherapy with standard chemotherapy to see if it helps people with advanced triple-negative breast cancer.

  Recruiting at 5 sites Phase 1 National Cancer Institute (NCI) · Boston, Massachusetts and 5 other locations · NCT05422794

• Using minoxidil to treat hair loss in breast cancer patients on endocrine therapy

  This study is testing if a hair loss treatment called minoxidil, given either as a foam or a pill, can help women with breast cancer who are losing their hair due to cancer therapy.

  Recruiting Early Phase 1 Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT05417308

• Imaging HER2+ Breast Cancer with Brain Metastasis using a New Scan

  This study is testing a new type of scan to see if it can help doctors better understand how well a treatment works for people with HER2+ breast cancer that has spread to the brain.

  Recruiting Phase 4 City of Hope Medical Center · Duarte, California · NCT05376878

• Combining two anti-cancer drugs for patients with advanced tumors

  This study is testing a new combination of two anti-cancer drugs to see if it can help teenagers and adults with advanced tumors feel better and improve their treatment options.

  Recruiting at 7 sites Phase 1 National Cancer Institute (NCI) · Los Angeles, California and 6 other locations · NCT05372640

• Combining Ivermectin with Balstilimab for Advanced Triple Negative Breast Cancer

  This study is testing whether combining ivermectin with balstilimab or pembrolizumab can help people with advanced triple negative breast cancer by shrinking tumors and improving their quality of life.

  Recruiting Phase 1/2 Cedars-Sinai Medical Center · Los Angeles, California · NCT05318469

• Personalized vaccine combined with pembrolizumab for advanced solid tumors

  This study is testing a new personalized cancer vaccine combined with pembrolizumab to see if it helps people with advanced solid tumors fight their cancer better.

  Recruiting Phase 1/2 Mayo Clinic · Jacksonville, Florida · NCT05269381

• Personalized vaccine treatment for advanced melanoma, breast cancer, and lung cancer

  This study is testing a personalized vaccine combined with a treatment called nivolumab to see if it can help people with advanced melanoma, breast cancer, or lung cancer fight their tumors better.

  Recruiting Phase 1 Fred Hutchinson Cancer Center · Seattle, Washington · NCT05098210

• Combining Tumor Treating Fields with Cabozantinib or Pembrolizumab and Nab-Paclitaxel for Advanced Solid Tumors

  This study is testing a new treatment that combines tumor treating fields with two different cancer drugs to see if it helps people with advanced solid tumors in the abdomen or chest.

  Recruiting Phase 1 M.D. Anderson Cancer Center · Houston, Texas · NCT05092373

• Avapritinib for treating advanced solid tumors with specific mutations

  This study is testing if a new drug called avapritinib can help people with advanced solid tumors that have specific mutations feel better and live longer after other treatments haven't worked.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT04771520

• Lutetium-177 DOTATATE for Stage IV or Recurrent Breast Cancer

  This study tests whether 177Lu-DOTATATE can shrink or slow the growth of breast cancer that has spread or come back in patients whose tumors express SSTR2.

  Recruiting Phase 2 OHSU Knight Cancer Institute · Portland, Oregon · NCT04529044

• Investigating biomarkers and clinical features in metastatic breast cancer patients treated with CDK4/6 inhibitors

  This study is trying to learn more about how metastatic breast cancer patients respond to CDK4/6 inhibitors by looking at their medical records and collecting blood and tissue samples to understand the cancer better.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT04526587

• A vaccine using modified measles virus for treating metastatic breast cancer

  This study is testing a modified measles virus vaccine to see if it can safely help people with metastatic breast cancer by shrinking their tumors.

  Recruiting Phase 1 Mayo Clinic · Rochester, Minnesota · NCT04521764

• Dendritic cell vaccines and pembrolizumab for treating brain metastasis from breast cancer

  This study is testing a new vaccine combined with an immune therapy to see if it can help people with brain metastasis from triple negative or HER2+ breast cancer fight their cancer better.

  Recruiting at 2 sites Phase 2 Roswell Park Cancer Institute · Tampa, Florida and 2 other locations · NCT04348747

• Using abemaciclib to treat older patients with hormone receptor positive breast cancer

  This study is testing if the medication abemaciclib can safely help older patients with hormone receptor positive breast cancer feel better and live longer.

  Recruiting at 6 sites Phase 2 City of Hope Medical Center · Duarte, California and 5 other locations · NCT04305834

• Combining Olaparib with Cediranib or AZD6738 for Advanced Breast Cancer with BRCA Mutations

  This study is testing if combining the drugs olaparib with either cediranib or AZD6738 can help women with advanced breast cancer that has BRCA mutations feel better after they’ve already tried other treatments.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT04090567

• Real-time imaging of tumor blood vessels during surgery

  We will test whether a real-time microscope technique during surgery can show how well blood vessels in adults' solid tumors work and whether that helps predict if systemic cancer medicines can reach the tumor.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT03823144

• Monitoring breast cancer using serum tumor markers

  This study is testing if using blood tests to monitor hormone receptor positive, HER2 negative metastatic breast cancer can help patients live as long as those who receive standard monitoring while also looking at costs and how patients feel.

  Recruiting at 592 sites SWOG Cancer Research Network · Anchorage, Alaska and 722 other locations · NCT03723928

• Combining a personalized vaccine with chemotherapy and immunotherapy for metastatic triple-negative breast cancer

  This study is testing if adding a personalized vaccine to chemotherapy and immunotherapy can help people with metastatic triple-negative breast cancer feel better and improve their treatment outcomes.

  Recruiting at 24 sites Phase 2 National Cancer Institute (NCI) · Orange, California and 29 other locations · NCT03606967

Related topics

Quick answers

How many Anatomic Stage IV Breast Cancer AJCC v8 clinical trials are recruiting right now?

43, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 3 countries. The most sites are in United States (43 trials), Puerto Rico (2 trials), Guam (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 19, Phase 1: 8, Phase 1/2: 4, Phase 3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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