Condition

Stage IV Renal Cell Cancer AJCC v8 clinical trials and research

• 19Clinical trials
• 5Countries

Newest Stage IV Renal Cell Cancer AJCC v8 clinical trials

All recruiting trials (19)

• Neoadjuvant immunotherapy with botensilimab and balstilimab for high-risk non-metastatic clear cell RCC

  This trial tests whether giving botensilimab and balstilimab before kidney tumor surgery is safe and helps patients with high‑risk non‑metastatic clear cell RCC proceed to nephrectomy.

  Recruiting at 5 sites Phase 2 National Cancer Institute (NCI) · Irvine, California and 4 other locations · NCT07516366

• VSV-IFNβ-NIS plus ipilimumab and nivolumab for advanced or metastatic clear cell renal cell carcinoma

  This trial adds a virus-based therapy (VSV-IFNβ-NIS) to standard immunotherapy (ipilimumab and nivolumab) to see if it helps people with advanced or metastatic clear cell renal cell cancer.

  Recruiting Phase 2 Mayo Clinic · Rochester, Minnesota · NCT07510334

• Morning versus afternoon immunotherapy for advanced or metastatic solid tumors

  This trial tests whether giving standard immune checkpoint inhibitor therapy in the morning versus the afternoon changes outcomes for adults with advanced or metastatic solid tumors.

  Recruiting Phase 4 OHSU Knight Cancer Institute · Portland, Oregon · NCT07405086

• Adding a probiotic to standard immunotherapy for advanced kidney cancer

  This trial tests whether adding MO-03 probiotic to standard immunotherapy helps people with advanced or metastatic clear cell kidney cancer.

  Recruiting at 41 sites Phase 3 SWOG Cancer Research Network · Fayetteville, Arkansas and 40 other locations · NCT07383441

• Ivonescimab given before surgery for high-risk localized clear cell kidney cancer

  This study tests whether giving ivonescimab before nephrectomy helps patients with high-risk localized clear cell renal cell carcinoma.

  Recruiting Phase 2 City of Hope Medical Center · Duarte, California · NCT07226544

• Nivolumab and ipilimumab with or without EXL01 for advanced or metastatic clear-cell and sarcomatoid renal cell carcinoma

  This trial tests whether adding EXL01, a live Faecalibacterium prausnitzii product, to nivolumab and ipilimumab helps adults with advanced or metastatic clear-cell or sarcomatoid renal cell cancer.

  Recruiting at 2 sites Phase 1 City of Hope Medical Center · Duarte, California and 1 other locations · NCT07128680

• Adding CBM588 to pembrolizumab after surgery for kidney cancer

  This trial tests whether adding CBM588 to pembrolizumab after kidney cancer surgery helps prevent recurrence compared with pembrolizumab alone.

  Recruiting at 2 sites Phase 2 City of Hope Medical Center · Duarte, California and 1 other locations · NCT07037004

• Using 18F-TRX to image solid tumors

  This trial tests whether the 18F-TRX PET tracer can detect tumors in adults with advanced solid tumors such as high‑grade glioma, clear cell renal cell carcinoma, or metastatic castration‑resistant prostate cancer.

  Recruiting Phase 1 University of California, San Francisco · San Francisco, California · NCT06942104

• Inulin gel plus ipilimumab and nivolumab for advanced kidney (renal cell) cancer

  This trial tests whether adding an inulin gel to the immunotherapy drugs ipilimumab and nivolumab helps people with locally advanced or metastatic clear cell or sarcomatoid renal cell carcinoma.

  Recruiting Phase 1/2 University of Michigan Rogel Cancer Center · Ann Arbor, Michigan · NCT06866262

• Predicting how tumors respond to immune therapies using a live diagnostic platform

  This study is testing a new way to predict how well immune therapies will work for patients with different types of solid tumors, including early-stage and metastatic cancers.

  Recruiting at 3 sites Mayo Clinic · Phoenix, Arizona and 2 other locations · NCT06349642

• Comparing home and clinic administration of nivolumab for cancer treatment

  This study tests whether giving cancer patients their treatment at home instead of in a clinic makes them feel better and prefer their care more.

  Recruiting Phase 2 Mayo Clinic · Jacksonville, Florida · NCT06265285

• Genetic testing to choose the best treatment for advanced kidney cancer

  This study is testing if using genetic testing to pick the best treatment can help people with advanced kidney cancer respond better to either a combination of immunotherapy drugs or a mix of immunotherapy and targeted therapy.

  Recruiting at 6 sites Phase 2 Vanderbilt-Ingram Cancer Center · Duarte, California and 5 other locations · NCT05361720

• Combining Stereotactic Radiation with Immune Therapy for Advanced Kidney Cancer

  This study is testing whether adding a special type of radiation therapy to standard immune treatment can help people with advanced kidney cancer live longer and feel better.

  Recruiting at 303 sites Phase 2 NRG Oncology · Birmingham, Alabama and 347 other locations · NCT05327686

• Personalized vaccine combined with pembrolizumab for advanced solid tumors

  This study is testing a new personalized cancer vaccine combined with pembrolizumab to see if it helps people with advanced solid tumors fight their cancer better.

  Recruiting Phase 1/2 Mayo Clinic · Jacksonville, Florida · NCT05269381

• Combining Tumor Treating Fields with Cabozantinib or Pembrolizumab and Nab-Paclitaxel for Advanced Solid Tumors

  This study is testing a new treatment that combines tumor treating fields with two different cancer drugs to see if it helps people with advanced solid tumors in the abdomen or chest.

  Recruiting Phase 1 M.D. Anderson Cancer Center · Houston, Texas · NCT05092373

• Combining three medications for advanced kidney cancer treatment

  This study is testing a combination of three medications to see if they can help people with advanced kidney cancer feel better and live longer.

  Recruiting at 6 sites Phase 2 National Cancer Institute (NCI) · La Jolla, California and 12 other locations · NCT04981509

• Combining cryoablation and radiation therapy for painful bone metastases

  This study is testing if combining a freezing treatment with radiation can help people with painful bone cancer feel better compared to just using radiation alone.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT04693377

• Comparing immunotherapy with and without kidney surgery for metastatic kidney cancer

  This study is testing whether adding kidney surgery to a standard immunotherapy treatment can help people with advanced kidney cancer live longer and feel better.

  Recruiting at 340 sites Phase 3 SWOG Cancer Research Network · Birmingham, Alabama and 386 other locations · NCT04510597

• Combining immunotherapy and targeted therapy for rare bladder tumors

  This study is testing a new combination of treatments for people with rare bladder tumors that have spread, to see if it helps them live longer and feel better.

  Recruiting at 222 sites Phase 2 National Cancer Institute (NCI) · Birmingham, Alabama and 581 other locations · NCT03866382

Related topics

Quick answers

How many Stage IV Renal Cell Cancer AJCC v8 clinical trials are recruiting right now?

19, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in United States (19 trials), Australia (1 trial), Canada (1 trial), Ireland (1 trial), Puerto Rico (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 9, Phase 1: 3, Phase 1/2: 2, Phase 3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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