Condition

Metastatic Lung Non-Small Cell Carcinoma clinical trials and research

• 20Clinical trials
• 10Countries

Newest Metastatic Lung Non-Small Cell Carcinoma clinical trials

All recruiting trials (20)

• 64Cu-DOTA-Pembrolizumab PET to See If Treatment Is Working in Stage IV NSCLC

  This study tests a new PET imaging agent paired with pembrolizumab to see if it can show which tumors are still responding in adults with stage IV NSCLC who are already receiving pembrolizumab.

  Recruiting Phase 1 City of Hope Medical Center · Duarte, California · NCT07619599

• Morning versus afternoon immunotherapy for advanced or metastatic solid tumors

  This trial tests whether giving standard immune checkpoint inhibitor therapy in the morning versus the afternoon changes outcomes for adults with advanced or metastatic solid tumors.

  Recruiting Phase 4 OHSU Knight Cancer Institute · Portland, Oregon · NCT07405086

• SX-682 with Atezolizumab for advanced or metastatic NSCLC

  This phase 2 trial tests whether combining SX-682 with atezolizumab can help people with advanced, metastatic, or recurrent NSCLC who have progressed after prior treatments.

  Recruiting Phase 2 University of Washington · Seattle, Washington · NCT07322341

• GT103 plus pembrolizumab for advanced STK11‑mutant non‑small cell lung cancer

  This trial tests whether adding GT103 to pembrolizumab can help adults with advanced or metastatic STK11‑mutant non‑small cell lung cancer.

  Recruiting Phase 2 Roswell Park Cancer Institute · Buffalo, New York · NCT07017829

• Combining sotorasib and trastuzumab deruxtecan for advanced KRAS G12C non-small cell lung cancer

  This trial tests whether giving sotorasib with trastuzumab deruxtecan is safe and can shrink tumors or slow progression in people with locally advanced or metastatic non-small cell lung cancer that has a KRAS G12C mutation and progressed after prior targeted therapy, immunotherapy, and chemotherapy.

  Recruiting at 9 sites Phase 1/2 National Cancer Institute (NCI) · Sacramento, California and 8 other locations · NCT07012031

• Photon VMAT craniospinal radiation for leptomeningeal disease from breast or non‑small cell lung cancer

  This trial tests whether craniospinal irradiation delivered with photon VMAT can help adults whose breast cancer or non‑small cell lung cancer has spread to the meninges (leptomeningeal disease).

  Recruiting at 2 sites Phase 2 City of Hope Medical Center · Duarte, California and 1 other locations · NCT06910761

• Adding diclofenac to single-agent immunotherapy for metastatic non-small cell lung cancer

  This trial tests if adding the NSAID diclofenac to single‑agent PD‑1/PD‑L1 immunotherapy can help people with metastatic non‑small cell lung cancer who are showing early signs of progression.

  Recruiting at 2 sites Phase 2 Emory University · Atlanta, Georgia and 1 other locations · NCT06731270

• Hippocampal avoidance during craniospinal irradiation for breast and lung cancer with leptomeningeal metastases

  This study is testing a new way of giving radiation therapy to help people with breast or lung cancer that has spread to their brain, aiming to reduce symptoms while protecting their memory.

  Recruiting at 2 sites Phase 2 University of Washington · San Francisco, California and 2 other locations · NCT06518057

• Comparing proton radiation therapy to standard radiation for leptomeningeal metastasis

  This study is testing whether proton radiation therapy is better than standard radiation for people with leptomeningeal metastasis from breast or lung cancer to see if it helps them live longer and stay healthier.

  Recruiting at 58 sites Phase 3 NRG Oncology · Phoenix, Arizona and 57 other locations · NCT06500481

• Evaluating insomnia in patients with metastatic lung cancer

  This study looks at how common sleep problems are in people with advanced lung cancer to better understand their struggles with insomnia.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT06472804

• Predicting how tumors respond to immune therapies using a live diagnostic platform

  This study is testing a new way to predict how well immune therapies will work for patients with different types of solid tumors, including early-stage and metastatic cancers.

  Recruiting at 3 sites Mayo Clinic · Phoenix, Arizona and 2 other locations · NCT06349642

• Combining carfilzomib and sotorasib for treating advanced lung cancer with KRAS G12C mutation

  This study is testing a new combination of two drugs, carfilzomib and sotorasib, to see if it can safely help people with advanced lung cancer that has a specific KRAS G12C mutation after they have tried other treatments.

  Recruiting at 2 sites Phase 1 City of Hope Medical Center · Duarte, California and 1 other locations · NCT06249282

• Evaluating BDTX-4933 for patients with specific cancer mutations

  This study is testing a new drug called BDTX-4933 to see if it can help adults with advanced cancers that have certain gene mutations feel better and improve their treatment options.

  Recruiting at 34 sites Phase 1/2 Servier · Gilbert, Arizona and 48 other locations · NCT05786924

• Combining SX-682 and Pembrolizumab for Advanced Lung Cancer Treatment

  This study is testing if a new oral medication called SX-682, when combined with the IV drug pembrolizumab, can help people with advanced lung cancer feel better and improve their treatment outcomes.

  Recruiting Phase 2 University of Washington · Seattle, Washington · NCT05570825

• Personalized vaccine combined with pembrolizumab for advanced solid tumors

  This study is testing a new personalized cancer vaccine combined with pembrolizumab to see if it helps people with advanced solid tumors fight their cancer better.

  Recruiting Phase 1/2 Mayo Clinic · Jacksonville, Florida · NCT05269381

• Combining PBF-1129 and Nivolumab for Advanced Lung Cancer Treatment

  This study is testing a new combination of two drugs, PBF-1129 and nivolumab, to see if it can help people with advanced lung cancer live longer and feel better.

  Recruiting Phase 1 Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT05234307

• Personalized vaccine treatment for advanced melanoma, breast cancer, and lung cancer

  This study is testing a personalized vaccine combined with a treatment called nivolumab to see if it can help people with advanced melanoma, breast cancer, or lung cancer fight their tumors better.

  Recruiting Phase 1 Fred Hutchinson Cancer Center · Seattle, Washington · NCT05098210

• Combining osimertinib and tegavivint for treating metastatic EGFR-mutant lung cancer

  This study is testing a new combination of two drugs, osimertinib and tegavivint, to see if it can help people with advanced lung cancer caused by EGFR mutations feel better and live longer.

  Recruiting Phase 1 Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT04780568

• Combining MRX-2843 and Osimertinib for Advanced Lung Cancer Treatment

  This study is testing whether combining two medications, MRX-2843 and osimertinib, can safely help people with advanced lung cancer caused by EGFR mutations.

  Recruiting Phase 1 Emory University · Atlanta, Georgia · NCT04762199

• Investigating PET/CT changes during treatment for advanced lung cancer

  This study is testing how PET and CT scans change during treatment for advanced lung cancer to see if they can help predict how well the treatment is working.

  Recruiting University of Washington · Seattle, Washington · NCT04151940

Related topics

Quick answers

How many Metastatic Lung Non-Small Cell Carcinoma clinical trials are recruiting right now?

20, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in United States (20 trials), Australia (1 trial), China (1 trial), Denmark (1 trial), France (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 6, Phase 1: 6, Phase 1/2: 3, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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