Condition

Stage III Lung Cancer AJCC v8 clinical trials and research

• 22Clinical trials
• 2Countries

Newest Stage III Lung Cancer AJCC v8 clinical trials

All recruiting trials (22)

• Morning versus afternoon immunotherapy for advanced or metastatic solid tumors

  This trial tests whether giving standard immune checkpoint inhibitor therapy in the morning versus the afternoon changes outcomes for adults with advanced or metastatic solid tumors.

  Recruiting Phase 4 OHSU Knight Cancer Institute · Portland, Oregon · NCT07405086

• SX-682 with Atezolizumab for advanced or metastatic NSCLC

  This phase 2 trial tests whether combining SX-682 with atezolizumab can help people with advanced, metastatic, or recurrent NSCLC who have progressed after prior treatments.

  Recruiting Phase 2 University of Washington · Seattle, Washington · NCT07322341

• GT103 plus pembrolizumab for advanced STK11‑mutant non‑small cell lung cancer

  This trial tests whether adding GT103 to pembrolizumab can help adults with advanced or metastatic STK11‑mutant non‑small cell lung cancer.

  Recruiting Phase 2 Roswell Park Cancer Institute · Buffalo, New York · NCT07017829

• Combining sotorasib and trastuzumab deruxtecan for advanced KRAS G12C non-small cell lung cancer

  This trial tests whether giving sotorasib with trastuzumab deruxtecan is safe and can shrink tumors or slow progression in people with locally advanced or metastatic non-small cell lung cancer that has a KRAS G12C mutation and progressed after prior targeted therapy, immunotherapy, and chemotherapy.

  Recruiting at 9 sites Phase 1/2 National Cancer Institute (NCI) · Sacramento, California and 8 other locations · NCT07012031

• Better Breathing for Early-Stage Lung Cancer Survivors (New York)

  This program tests whether a 12-week home-based breathing exercise routine helps people who had stage I–III lung cancer breathe better, feel less tired, and stay more active.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT06869447

• Adding diclofenac to single-agent immunotherapy for metastatic non-small cell lung cancer

  This trial tests if adding the NSAID diclofenac to single‑agent PD‑1/PD‑L1 immunotherapy can help people with metastatic non‑small cell lung cancer who are showing early signs of progression.

  Recruiting at 2 sites Phase 2 Emory University · Atlanta, Georgia and 1 other locations · NCT06731270

• Combination treatment for advanced lung cancer with specific mutations

  This study is testing a new combination of medications for people with advanced lung cancer that has specific mutations and hasn't improved with other treatments, to see if it helps them live longer without the cancer getting worse.

  Recruiting at 2 sites Phase 2 Emory University · Atlanta, Georgia and 2 other locations · NCT06495125

• Combining carfilzomib and sotorasib for treating advanced lung cancer with KRAS G12C mutation

  This study is testing a new combination of two drugs, carfilzomib and sotorasib, to see if it can safely help people with advanced lung cancer that has a specific KRAS G12C mutation after they have tried other treatments.

  Recruiting at 2 sites Phase 1 City of Hope Medical Center · Duarte, California and 1 other locations · NCT06249282

• Evaluating geriatric assessments for older adults with lung cancer undergoing treatment

  This study tests if using special health assessments for older adults with lung cancer can help them handle treatment better and improve their quality of life.

  Recruiting at 2 sites City of Hope Medical Center · Duarte, California and 2 other locations · NCT06139627

• Improving decision-making for lung cancer treatment

  This study is testing a new communication tool to see if it helps patients with non-small cell lung cancer feel more satisfied and confident in their treatment choices when talking with their doctors.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT06122064

• Monitoring T Cell Responses in Cancer Patients Receiving Anti-PD-1 Therapy

  This study is trying to see how T cells in the blood can help doctors understand how well anti-PD-1 therapy works for people with melanoma, lung cancer, and other cancers.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT06075524

• CPI-613 combined with hydroxychloroquine and chemotherapy for advanced solid tumors

  This study is testing a new combination of treatments, including CPI-613 and hydroxychloroquine, to see if it can help people with advanced solid tumors that haven't improved with other chemotherapy.

  Recruiting Phase 2 Northwestern University · Chicago, Illinois · NCT05733000

• Adding high dose targeted radiation to usual treatment for advanced lung cancer

  This study is testing if adding a high dose of targeted radiation to the usual chemotherapy and immunotherapy can help people with advanced lung cancer live longer and feel better.

  Recruiting at 446 sites Phase 3 NRG Oncology · Birmingham, Alabama and 476 other locations · NCT05624996

• Surgical order of blood vessel division and circulating tumor DNA after lung cancer surgery

  This compares doing the pulmonary vein first versus the pulmonary artery first during lung cancer surgery to see if it lowers circulating tumor DNA in adults with stage I–III non-small cell lung cancer.

  Recruiting at 4 sites Thomas Jefferson University · Abington, Pennsylvania and 3 other locations · NCT05502523

• Personalized vaccine combined with pembrolizumab for advanced solid tumors

  This study is testing a new personalized cancer vaccine combined with pembrolizumab to see if it helps people with advanced solid tumors fight their cancer better.

  Recruiting Phase 1/2 Mayo Clinic · Jacksonville, Florida · NCT05269381

• Using papaverine with chemoradiation to treat advanced non-small cell lung cancer

  This study is testing the best dose of papaverine combined with chemotherapy and radiation to see if it helps people with advanced non-small cell lung cancer live longer and control their tumors better.

  Recruiting at 2 sites Phase 1 Ohio State University Comprehensive Cancer Center · Duarte, California and 1 other locations · NCT05136846

• Personalized vaccine treatment for advanced melanoma, breast cancer, and lung cancer

  This study is testing a personalized vaccine combined with a treatment called nivolumab to see if it can help people with advanced melanoma, breast cancer, or lung cancer fight their tumors better.

  Recruiting Phase 1 Fred Hutchinson Cancer Center · Seattle, Washington · NCT05098210

• Assessing heart health in lung cancer patients receiving personalized chemoradiation

  This study is testing how personalized chemoradiation treatment for lung cancer affects heart health in patients and if adjusting the treatment can help reduce heart disease risk.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT05010109

• Combining local therapy and durvalumab for advanced lung cancer after initial treatment

  This study is testing whether combining local treatments like surgery or radiation with the immunotherapy durvalumab can help people with advanced lung cancer live longer and feel better after their initial treatment.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT04892953

• Using canakinumab to prevent lung cancer in high-risk patients

  This study is testing if a medication called canakinumab can help prevent lung cancer in people who have high-risk lung nodules.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT04789681

• Yoga intervention to improve physical performance and quality of life for cancer patients and their caregivers

  This study tests whether a yoga program can help improve physical performance and quality of life for cancer patients and their caregivers during radiotherapy.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT03948100

• Exploring gut microbiome and fecal transplant effects on GI issues in cancer patients

  This study is testing how the gut bacteria affect stomach issues in cancer patients receiving certain treatments and whether a stool transplant can help relieve those problems.

  Recruiting Phase 1 M.D. Anderson Cancer Center · Houston, Texas · NCT03819296

Related topics

Quick answers

How many Stage III Lung Cancer AJCC v8 clinical trials are recruiting right now?

22, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in United States (22 trials), Canada (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 7, Phase 1: 4, Phase 1/2: 2, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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